CardioPulmonary Vascular Biology COBRE
心肺血管生物学 COBRE
基本信息
- 批准号:10630735
- 负责人:
- 金额:$ 91.35万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-06-01 至 2028-05-31
- 项目状态:未结题
- 来源:
- 关键词:2019-nCoVAdvisory CommitteesAffectAreaAwardBiologyBlood VesselsCOVID-19 pandemicCardiopulmonaryCardiovascular DiseasesCardiovascular systemCause of DeathCell SeparationCenters of Research ExcellenceCollaborationsCommunitiesCoronary ArteriosclerosisDataDevelopmentDisciplineDiseaseEducational workshopFeedbackFosteringFundingGoalsGrowthHomeHumanInfectionInfrastructureInstitutionInvestigationLearningLegal patentLungLung diseasesManuscriptsMissionMitochondriaMorbidity - disease rateOrganPathogenesisPhasePilot ProjectsPreventionProductivityPrognosisPublishingResearchResearch PersonnelResearch Project GrantsResourcesRespiratory DiseaseRhode IslandScientistServicesStructureVascular DiseasesVirusVisioncareercatalystcombatcomorbidityeffective therapyin vivo imagingmortalitypreventprogramspulmonary vascular disorderrespiratory
项目摘要
The vision of the CardioPulmonary Vascular Biology (CPVB) COBRE program is to develop effective approaches
to prevent and treat vascular diseases affecting the pulmonary and cardiovascular systems through better
understanding of disease mechanisms. This will be accomplished by serving as an interdisciplinary center which
promotes collaborative research and provides excellent technical support and resources to investigators. The
overall mission of the CPVB COBRE program has been to build the human and technical infrastructure and
services that serve as catalysts to increase CPVB research in the state. Cardiovascular and pulmonary diseases
are among the leading causes of morbidity and mortality in the US and in the world. Coronary artery disease
(CAD) is the leading cause of morbidity and mortality. Respiratory diseases are the 3rd and 4th leading causes
of death and are frequently complicated by pulmonary vasculopathy and cardiovascular co-morbidities that
markedly worsen prognosis. We have learned that infection with SARS-CoV-2 virus damages multiple organs,
with cardiovascular, respiratory, and vascular complications. Thus, there is an important need to understand the
pathogenesis of cardiopulmonary vascular diseases in order to develop more effective treatments and
prevention. The overall goal of the CPVB COBRE program is to facilitate high impact vascular biology research.
The CPVB COBRE program provides infrastructure with administrative, pilot project, and two technical cores,
thus providing opportunities to expand areas of investigation, experimental and technical approaches, and
scientific collaborations. The specific aims of Phase III CPVB COBRE are to: i) award high-impact research
projects in the area of cardiopulmonary vascular biology; ii) provide effective and high-quality services in cell
isolation and ex vivo organ function (CIOF), mitochondrial function, and in vivo imaging (MF-II); iii) collaborate
with IDeA programs in Rhode Island (RI) and other states to foster scientific networks by providing programming,
funding, technical services, and resources to enhance research productivity; and iv) maintain a robust line of
investigation in vascular biology that meets the needs of the scientific community and furthers research in
prevention and treatment of cardiopulmonary vascular diseases. Continuation of the CPVB COBRE into Phase
III will sustain the administrative structure for seminars and workshop planning, engagement, and professional
development support of investigators, and expertise in cell isolation and ex vivo organ function, mitochondrial
function, and in vivo imaging. We will expand and enrich the vascular biology research community by promoting
new collaborations and engaging scientists new to the field from a variety of disciplines. At the end of Phase III,
we expect to transition to a sustainable CPVB Center serving as a home to the CVPB research community with
high quality core services, significant institutional support, and commitment to continue the development of
effective approaches to combat or resolve cardiopulmonary vascular diseases.
心肺血管生物学(CPVB) COBRE项目的愿景是开发有效的方法
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Gaurav Choudhary其他文献
Gaurav Choudhary的其他文献
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{{ truncateString('Gaurav Choudhary', 18)}}的其他基金
Deep learning for algorithmic detection of pulmonary hypertension using a combined digital stethoscope and single-lead electrocardiogram
使用组合数字听诊器和单导联心电图进行肺动脉高压算法检测的深度学习
- 批准号:
10705310 - 财政年份:2022
- 资助金额:
$ 91.35万 - 项目类别:
Deep learning for algorithmic detection of pulmonary hypertension using a combined digital stethoscope and single-lead electrocardiogram
使用组合数字听诊器和单导联心电图进行肺动脉高压算法检测的深度学习
- 批准号:
10547726 - 财政年份:2022
- 资助金额:
$ 91.35万 - 项目类别:
Role of Skeletal Muscle Mitochondrial Supercomplexes in Exercise Intolerance
骨骼肌线粒体超级复合物在运动不耐受中的作用
- 批准号:
10292886 - 财政年份:2019
- 资助金额:
$ 91.35万 - 项目类别:
Role of Endothelial Anoctamin-1 in Pulmonary Arterial Hypertension
内皮 Anoctamin-1 在肺动脉高压中的作用
- 批准号:
10200883 - 财政年份:2019
- 资助金额:
$ 91.35万 - 项目类别:
Role of Endothelial Anoctamin-1 in Pulmonary Arterial Hypertension
内皮 Anoctamin-1 在肺动脉高压中的作用
- 批准号:
10449284 - 财政年份:2019
- 资助金额:
$ 91.35万 - 项目类别:
Role of Endothelial Anoctamin-1 in Pulmonary Arterial Hypertension
内皮 Anoctamin-1 在肺动脉高压中的作用
- 批准号:
9803089 - 财政年份:2019
- 资助金额:
$ 91.35万 - 项目类别:
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Standard Grant














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