Next-generation 3 Tesla Human MRI System

项目摘要 这笔赠款将支持购买一台新的西门子3特斯拉全身人体核磁共振扫描仪，用于 阿蒂努拉·A·马蒂诺斯生物医学成像中心的基础、临床和翻译研究，服务于 马萨诸塞州布里格姆总医院和波士顿地区其他医院和学术机构的调查人员。下一个- 新一代3T全身系统将作为我们现有的、已过时的3Tesla MRI的升级 即将达到供应商支持终止状态的扫描仪，并且在 过去的5年里。建议的具有高性能梯度的下一代3T系统将实现非常高的 用于全身成像的梯度强度和转斜率(每个轴高达200mT/m和200T/m/S)。会的 为马萨诸塞州布里格姆将军进行的广泛研究提供大幅提高的性能 而大波士顿地区，由超过25名调查人员和30个项目在共享使用的基础上证明是合理的，广阔的 其中大部分是由美国国立卫生研究院资助的。支持的研究范围包括临床研究和翻译研究 神经成像，心血管，身体和肿瘤成像；胎儿和儿童脑成像；认知， 精神病学、基础神经科学和脑成像研究；以及新仪器的开发。而当 马蒂诺斯中心的3Tesla MRI研究计划非常成功，系统将被更换 使用过时的硬件和软件，给我们的其他3个特斯拉系统带来了巨大的压力，这些系统无法 满足我们不断扩大的用户群体的先进技术需求。因为独一无二的 新的最先进的3T全身核磁共振，拟议的下一代3特斯拉人类核磁共振的能力 升级将提供用于提高性能和数据质量的新功能，这将使现有项目和 补充马提诺斯中心的其他扫描仪。此升级的特点：更高的性能梯度 脑、心脏和前列腺组织微结构的高空间分辨率成像和描绘； 具有128个接收通道和更高密度的专用线圈的增强型射频系统架构；简化 工作流程更易于使用；标准化的硬件和软件可与其他站点兼容；速度更快 支持现代成像技术的图像重建计算机；集成生理监测；新 用于加速多对比度检查的序列和应用程序包；以及最新的 在马蒂诺斯中心进行了独特的仪器和技术开发，包括最新的 用于脉冲序列编程和定制扫描仪图像重建的软件平台。通过为一名 由NIH资助的研究人员组成的高效跨学科小组，拟议的升级将提供一个削减- 前沿研究资源，将在更精细的尺度上推动结构-功能关系研究的前沿 和更高的敏感性，从而加强现有的研究计划并培养新项目的机会 和合作。这次仪器升级将为我们的调查人员提供技术优势 创新的临床、翻译和基础研究所需的。

PROJECT ABSTRACT This grant will support the purchase of a new Siemens 3 Tesla whole-body human MRI scanner to be used for basic, clinical and translational research at the Athinoula A. Martinos Center for Biomedical Imaging, serving investigators at Mass General Brigham and other Boston area hospitals and academic institutions. The next- generation 3T whole-body system will serve as an upgrade of our existing, 16-year-old obsolete 3 Tesla MRI scanner that is reaching imminent end-of-support status by the vendor and has seen diminishing usage over the last 5 years. The proposed next-generation 3T system with high performance gradients will enable very high gradient strengths and slew rates (up to 200 mT/m and 200 T/m/s on each axis) for whole-body imaging. It will offer a substantial increase of performance for the wide range of research performed at Mass General Brigham and the greater Boston area, justified on a shared-use basis by over 25 investigators and 30 projects, the vast majority of which are NIH-funded. The breadth of supported research spans clinical and translational neuroimaging, cardiovascular, body, and oncologic imaging; fetal and pediatric brain imaging; cognitive, psychiatric, and basic neuroscience and brain mapping studies; and novel instrumentation development. While the 3 Tesla MRI research program at the Martinos Center has been very successful, the system to be replaced uses outdated hardware and software, placing substantial pressure on our other 3 Tesla systems, which cannot accommodate the advanced technological needs of our expanding user community. Because of the unique capabilities of the new state-of-the-art 3T whole-body MRI, the proposed Next Generation 3 Tesla Human MRI upgrade will offer new features for improved performance and data quality that will benefit existing projects and complement the other scanners at the Martinos Center. This upgrade features: higher performance gradients for high spatial resolution tractography and delineation of tissue microstructure in the brain, heart and prostate; enhanced RF system architecture with 128 receive channels and higher density specialized coils; streamlined workflows for greater ease of use; standardized hardware and software for compatibility with other sites; a faster image reconstruction computer enabling modern imaging techniques; integrated physiological monitoring; new sequence and application packages for accelerated, multi-contrast exams; and an up-to-date testbed for the unique instrumentation and technology development performed at the Martinos Center, including the latest software platform for pulse sequence programming and custom on-scanner image reconstruction. By serving a highly productive interdisciplinary group of NIH-funded investigators, the proposed upgrade will offer a cutting- edge research resource that will push the frontiers of investigating structure-function relationships at finer scales and higher sensitivity, thereby enhancing existing research programs and fostering opportunities for new projects and collaborations. This instrumentation upgrade will provide our investigators with the technological edge required for innovative clinical, translational, and basic research.