权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

The influence of aerobic exercise on consolidation of fear extinction learning in PTSD

有氧运动对PTSD患者恐惧消退学习巩固的影响

基本信息

批准号：
10630706
负责人：
Kevin M Crombie
金额：
$ 3.59万
依托单位：
UNIVERSITY OF TEXAS AT AUSTIN
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-03-03 至 2023-08-15
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10630706
关键词：
Address Adult Aerobic Exercise Agonist American Amygdaloid structure Animal Model Anxiety Disorders Biometry Clinical Clinical Psychology Clinical Trials Cognitive Collaborations Computer Models Control Groups Dangerousness Data Diagnosis Disease remission Dose Endocannabinoids Enzymes Exercise Exhibits Expectancy Extinction FAAH inhibitor Fostering Fright Functional Magnetic Resonance Imaging Galvanic Skin Response Goals Hippocampus Image Individual Interdisciplinary Study International Knowledge Laboratories Laboratory Study Learning Light Mediating Memory Mental Health Mentored Research Scientist Development Award Mentorship Methodology Modeling Outcome Participant Pathway interactions Pattern Peripheral Pharmacology Physiological Pilot Projects Population Post-Traumatic Stress Disorders Prefrontal Cortex Process Psychiatry Psychophysiology Psychotherapy Randomized Regulation Research Research Personnel Retrieval Role Safety Sampling Signal Transduction Techniques Testing Texas Therapeutic Training Trauma Treatment Efficacy United States National Institutes of Health Universities Woman Work anandamide anxiety reduction austin career development clinical anxiety cognitive enhancement computational neuroscience design endogenous cannabinoid system exercise intensity experience fatty acid amide hydrolase improved indexing learning extinction lens memory consolidation memory encoding men multidisciplinary neural neural circuit neural patterning neurobiological mechanism neuroimaging notch protein pharmacologic response scaffold theories trauma exposure

项目摘要

PROJECT SUMMARY Exposure-based psychotherapies (e.g., prolonged exposure) are among the best supported treatments for posttraumatic stress disorder (PTSD), yet remission rates for these front-line treatments are typically only 50- 60%. These therapies aim to reduce anxiety towards trauma reminders by enabling therapeutic safety learning, which is hypothesized to work via the mechanisms of fear extinction learning. As such, fear extinction paradigms are widely used as laboratory models of exposure therapy, under the notion that treatments that enhance extinction learning and recall in the lab may be promising candidates for improving the efficacy of exposure-based therapies. Results from our recent clinical pilot studies (without an imaging component) provided preliminary evidence suggesting moderate-intensity aerobic exercise can boost consolidation of fear extinction memories and enhance cognitive indices of extinction recall – an effect that was mediated by exercise-induced increases in anandamide (AEA; a primary endocannabinoid). Thus, this K01 project involves a randomized controlled fMRI laboratory study to: 1) test whether different doses of aerobic exercise (light-, moderate-, and high-intensity) delivered after extinction training improves cognitive, physiological, and neural indices of extinction recall including enhanced retrieval of multivariate patterns of extinction memory encoding (when tested 24hrs later), and 2) further probe the role of AEA by determining dose-response relationships between aerobic exercise intensities and peripheral AEA concentrations (and whether the exercise-induced increases in AEA mediate the aforementioned relationships) in trauma-exposed men and women with and without PTSD (N=120). The PI will receive training and mentorship including: 1) training in computational neuroscience theory and statistical techniques (e.g., multivariate imaging analyses and computational modeling to analyze psychophysiological and neuroimaging data), 2) clinical exposure and expertise in clinical models and neurocircuitry of PTSD and anxiety disorders, 3) gaining expertise in clinical trials to be able to design, conduct, and analyze pharmacological and non-pharmacological RCTs as an independent investigator, and 4) professional and career development activities to foster multi-disciplinary research collaborations. The proposed training and research will occur at The University of Texas at Austin and includes domestic and international collaborations with top-notch researchers, all of which have established extensive NIH research portfolios spanning several fields such as: computational neuroscience, psychiatry, clinical psychology, biostatistics, and pharmacology. Ultimately, the guidance and training experiences gained from the PI’s mentorship team, and the results obtained from this K01 award, will serve as a scaffolding for the PI to become an independent investigator capable of conducting impactful mental health research in PTSD and clinical anxiety populations by utilizing a multidisciplinary lens and advanced methodologies from the ever-advancing fields of psychiatry and computational neuroscience.

项目总结