High-Performance PET/CT Instrumentation

高性能 PET/CT 仪器

• 批准号: 10630552
• 负责人: Martin Anthony Lodge
• 金额: $ 199.96万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-03-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10630552
• 关键词: Acceleration; Adoption; Area; Biological Process; Cardiology; Communities; Data Analyses; Data Collection; Development; Disease; Environment; Funding; Human; Image; Imaging Techniques; Infection; Infrastructure; Methodology; Molecular Target; Neurosciences; Oncology; Performance; Positron-Emission Tomography; Process; Public Health; Radiochemistry; Radiopharmaceuticals; Research; Research Personnel; Resolution; System; Technology; Time; Translating; Translational Research; Treatment Effectiveness; United States National Institutes of Health; Visualization; X-Ray Computed Tomography; end of life; experience; flexibility; imaging capabilities; improved; in vivo; instrument; instrumentation; large datasets; molecular imaging

Project Summary / Abstract This proposal aims to upgrade the imaging capability of the Johns Hopkins Positron Emission Tomography (PET) Center with new high-performance, human-scale PET/CT instrumentation. PET is a non-invasive, molecular imaging technique that can be used to visualize and quantify functional processes in-vivo. A wide variety of biological processes and disease states can be studied by selection of an appropriate radiopharmaceutical. This flexibility and the scope for creating new radiopharmaceuticals to interrogate different targets means that the same scanner system can be used for a variety of research purposes. PET has made major contributions across many different fields including neuroscience, oncology, cardiology and others. The proposed new PET/CT instrument will be used exclusively for research and will replace two existing PET-only scanners that have reached their end-of-life. High spatial resolution, high sensitivity and outstanding time-of-flight capability, as well as in-line integration with x-ray CT mean the new scanner will greatly improve upon currently available technology. This enhanced technical performance will translate to higher image quality and quantitative parameters with greater accuracy and improved statistical reliability. The current proposal aims to take advantage of the existing infrastructure and environment at Johns Hopkins. The PET Center has well-equipped radiochemistry facilities and much experience in radiopharmaceutical development, PET imaging methodology and quantitative data analysis. There is also a large pool of NIH funded investigators who have struggled for some time with old, unreliable PET systems and limited access to PET/CT. Greater access and improved imaging capability will enhance the quality of data collection and accelerate accrual of large data sets. Furthermore, the new capabilities and flexibility of the proposed scanner will broaden the range of studies that are possible, encouraging new research applications and wider adoption of PET across the research community. This project will support and enhance NIH-funded research in neurosciences, oncology, cardiology and other areas including infection. The exquisite sensitivity of PET and its unique capability to target molecular processes in-vivo will drive advances in our understanding of disease. In addition, the quantitative capability of PET can help develop and assess new treatment options, providing objective evidence for treatment effectiveness at an early time point. As such the current proposal has the potential to advance translational research and contribute towards improved public health.

项目总结/摘要 这项建议旨在提升约翰霍普金斯正电子发射的成像能力 断层扫描（PET）中心，配备新型高性能人体PET/CT仪器。 PET是一种非侵入性的分子成像技术，可用于可视化和量化 体内的功能过程。各种各样的生物过程和疾病状态可以是 通过选择合适的放射性药物进行研究。这种灵活性和范围， 创造新的放射性药物来研究不同的目标意味着同一台扫描仪 系统可用于各种研究目的。PET在各个领域做出了重大贡献 许多不同的领域，包括神经科学、肿瘤学、心脏病学等。拟议的新 PET/CT仪器将专门用于研究，并将取代两台现有的PET专用仪器。 扫描仪已经到了生命的尽头。高空间分辨率、高灵敏度和 出色的飞行时间能力以及与X射线CT的在线集成意味着新的 扫描仪将大大改善目前可用的技术。这种增强的技术 性能将转化为更高的图像质量和定量参数， 提高统计的准确性和可靠性。目前的建议旨在利用 约翰霍普金斯现有的基础设施和环境。PET中心设备齐全， 放射化学设施和放射性药物开发、PET成像方面的丰富经验 方法和定量数据分析。也有大量的国家卫生研究院资助的研究人员 他们已经与旧的、不可靠的PET系统和有限的PET/CT进行了一段时间的斗争。 更多的接触和改进的成像能力将提高数据收集的质量， 加快大型数据集的积累。此外， 拟议的扫描仪将扩大可能的研究范围，鼓励新的研究 应用和更广泛地采用PET在整个研究界。该项目将支持 并加强NIH资助的神经科学、肿瘤学、心脏病学和其他领域的研究 包括感染。PET的灵敏度和其独特的靶向分子的能力 体内过程将推动我们对疾病理解的进步。此外，定量 PET的能力可以帮助开发和评估新的治疗方案， 早期治疗有效性的证据。因此，目前的提案具有 推动转化研究的潜力，并为改善公共卫生做出贡献。