Delineating the epigenetic and neural mechanisms by which early life scarcity alters motivated behavior

描述早期生命匮乏改变动机行为的表观遗传和神经机制

基本信息

  • 批准号:
    10631152
  • 负责人:
  • 金额:
    $ 63.91万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-07-01 至 2027-04-30
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY Early life experiences can have profound and long-lasting consequences on health trajectories. Social inequities, such as those caused by low resources, have been identified as important factors that influence the development of psychiatric illnesses, including substance use disorders (SUD). In this proposal, a rat model of early life scarcity will be combined with behavioral paradigms of substance abuse to better understand the neural and molecular mechanisms that influence reward processing in individuals who experienced adversity early in life. Each brain region contains highly heterogenous cell populations that include different neuronal subtypes as well as glia. Accounting for the diversity and differences in cell types is essential to improving our understanding of the impact of inequities on the brain and on motivated behavior. In this proposal, the influence of early life scarcity on adult reward processing and motivation will be characterized in male and female rats using state-of-the-art behavioral approaches where rats are tested for their motivation to earn drug (opioid) or natural (social and sucrose) rewards. Our preliminary data indicate sex- and reinforcer-specific effects of early scarcity. This work will be expanded here, and in some of the experiments, rats will choose between two available reinforcers. Given that interventions for SUD involve social reinforcers, these results could have profound implications for the prevention and treatment of SUD in populations who experience socioeconomic inequality. To better identify factors that mediate the effects of early scarcity on motivated behavior, we will delineate molecular changes in the nucleus accumbens—a central hub in the brain that is critical for motivated and reward-related behaviors— and causally link them to behavior. To this end, we will perform cell-type specific assays of gene expression and chromatin remodeling, an epigenetic process that regulates the expression of genes. Lastly, the proposal will examine the impact of early life scarcity on the electrophysiological properties of two major neuron subtypes in the nucleus accumbens, delineating cell type-specific physiological changes induced by altering the early environment. Collectively, this proposal leverages cutting-edge behavioral, molecular, and physiological approaches to provide a better understanding of the neurochemical and intracellular pathways affected by early life scarcity that drive changes in motivated behavior. Importantly, the proposed experiments will determine sex- and cell-type specific mechanisms by which early life scarcity alters the substance use trajectory, identifying potential targets for improving therapeutics and prevention of SUDs.
项目总结

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Debra A Bangasser其他文献

Antidepressant-Like Effects of κ-Opioid Receptor Antagonists in Wistar Kyoto Rats
κ-阿片受体拮抗剂在 Wistar Kyoto 大鼠中的抗抑郁样作用
  • DOI:
    10.1038/npp.2009.183
  • 发表时间:
    2009-11-18
  • 期刊:
  • 影响因子:
    7.100
  • 作者:
    Gregory V Carr;Debra A Bangasser;Thelma Bethea;Matthew Young;Rita J Valentino;Irwin Lucki
  • 通讯作者:
    Irwin Lucki

Debra A Bangasser的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Debra A Bangasser', 18)}}的其他基金

Determining the effect of early resource scarcity on adolescent addiction-related behavior and cell-type specific transcription
确定早期资源稀缺对青少年成瘾相关行为和细胞类型特异性转录的影响
  • 批准号:
    10825012
  • 财政年份:
    2023
  • 资助金额:
    $ 63.91万
  • 项目类别:
Sex differences in stress inoculation of addiction-like phenotypes
成瘾样表型应激接种的性别差异
  • 批准号:
    10757580
  • 财政年份:
    2023
  • 资助金额:
    $ 63.91万
  • 项目类别:
Cell-specific epigenetic and transcriptomic signatures of impulsivity and its regulation by stress in the nucleus accumbens
冲动的细胞特异性表观遗传和转录组特征及其受伏隔核应激的调节
  • 批准号:
    10592511
  • 财政年份:
    2023
  • 资助金额:
    $ 63.91万
  • 项目类别:
Delineating the epigenetic and neural mechanisms by which early life scarcity alters motivated behavior
描述早期生命匮乏改变动机行为的表观遗传和神经机制
  • 批准号:
    10508379
  • 财政年份:
    2022
  • 资助金额:
    $ 63.91万
  • 项目类别:
Discriminating hormonal and sex chromosomal origins of sex differences in the septohippocampal circuit
区分隔海马回路中性别差异的激素和性染色体起源
  • 批准号:
    10618821
  • 财政年份:
    2022
  • 资助金额:
    $ 63.91万
  • 项目类别:
Discriminating hormonal and sex chromosomal origins of sex differences in the septohippocampal circuit
区分隔海马回路中性别差异的激素和性染色体起源
  • 批准号:
    10757579
  • 财政年份:
    2022
  • 资助金额:
    $ 63.91万
  • 项目类别:
Discriminating hormonal and sex chromosomal origins of sex differences in the septohippocampal circuit
区分隔海马回路中性别差异的激素和性染色体起源
  • 批准号:
    10389770
  • 财政年份:
    2022
  • 资助金额:
    $ 63.91万
  • 项目类别:
Sex differences in stress inoculation of addiction-like phenotypes
成瘾样表型应激接种的性别差异
  • 批准号:
    10213001
  • 财政年份:
    2020
  • 资助金额:
    $ 63.91万
  • 项目类别:
Sex differences in stress inoculation of addiction-like phenotypes
成瘾样表型应激接种的性别差异
  • 批准号:
    10392452
  • 财政年份:
    2020
  • 资助金额:
    $ 63.91万
  • 项目类别:
Sex differences in stress inoculation of addiction-like phenotypes
成瘾样表型应激接种的性别差异
  • 批准号:
    10609158
  • 财政年份:
    2020
  • 资助金额:
    $ 63.91万
  • 项目类别:

相似海外基金

Co-designing a lifestyle, stop-vaping intervention for ex-smoking, adult vapers (CLOVER study)
为戒烟的成年电子烟使用者共同设计生活方式、戒烟干预措施(CLOVER 研究)
  • 批准号:
    MR/Z503605/1
  • 财政年份:
    2024
  • 资助金额:
    $ 63.91万
  • 项目类别:
    Research Grant
Early Life Antecedents Predicting Adult Daily Affective Reactivity to Stress
早期生活经历预测成人对压力的日常情感反应
  • 批准号:
    2336167
  • 财政年份:
    2024
  • 资助金额:
    $ 63.91万
  • 项目类别:
    Standard Grant
RAPID: Affective Mechanisms of Adjustment in Diverse Emerging Adult Student Communities Before, During, and Beyond the COVID-19 Pandemic
RAPID:COVID-19 大流行之前、期间和之后不同新兴成人学生社区的情感调整机制
  • 批准号:
    2402691
  • 财政年份:
    2024
  • 资助金额:
    $ 63.91万
  • 项目类别:
    Standard Grant
Elucidation of Adult Newt Cells Regulating the ZRS enhancer during Limb Regeneration
阐明成体蝾螈细胞在肢体再生过程中调节 ZRS 增强子
  • 批准号:
    24K12150
  • 财政年份:
    2024
  • 资助金额:
    $ 63.91万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Migrant Youth and the Sociolegal Construction of Child and Adult Categories
流动青年与儿童和成人类别的社会法律建构
  • 批准号:
    2341428
  • 财政年份:
    2024
  • 资助金额:
    $ 63.91万
  • 项目类别:
    Standard Grant
Understanding how platelets mediate new neuron formation in the adult brain
了解血小板如何介导成人大脑中新神经元的形成
  • 批准号:
    DE240100561
  • 财政年份:
    2024
  • 资助金额:
    $ 63.91万
  • 项目类别:
    Discovery Early Career Researcher Award
Laboratory testing and development of a new adult ankle splint
新型成人踝关节夹板的实验室测试和开发
  • 批准号:
    10065645
  • 财政年份:
    2023
  • 资助金额:
    $ 63.91万
  • 项目类别:
    Collaborative R&D
Usefulness of a question prompt sheet for onco-fertility in adolescent and young adult patients under 25 years old.
问题提示表对于 25 岁以下青少年和年轻成年患者的肿瘤生育力的有用性。
  • 批准号:
    23K09542
  • 财政年份:
    2023
  • 资助金额:
    $ 63.91万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Identification of new specific molecules associated with right ventricular dysfunction in adult patients with congenital heart disease
鉴定与成年先天性心脏病患者右心室功能障碍相关的新特异性分子
  • 批准号:
    23K07552
  • 财政年份:
    2023
  • 资助金额:
    $ 63.91万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Issue identifications and model developments in transitional care for patients with adult congenital heart disease.
成人先天性心脏病患者过渡护理的问题识别和模型开发。
  • 批准号:
    23K07559
  • 财政年份:
    2023
  • 资助金额:
    $ 63.91万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了