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Improving Individualized Assessments of Glaucoma Progression with Population-Based Electronic Health Record Data

利用基于人群的电子健康记录数据改进青光眼进展的个体化评估

基本信息

批准号：
10630915
负责人：
Swarup Sai Swaminathan
金额：
$ 22.47万
依托单位：
UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-06-01 至 2027-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10630915
关键词：
Adoption Advisory Committees African African American African Caribbean Age Agreement Algorithms Applet Artificial Intelligence Bayesian Analysis Bayesian Modeling Bayesian Prediction Biometry Blindness Chronic Clinical Clinical Data Clinical Research Clinical assessments Communities Cornea Country Data Data Analyses Data Science Databases Dedications Disease Progression Early Diagnosis Early Intervention Educational workshop Elderly Electronic Health Record Eligibility Determination Ethnic Origin Exhibits Eye Florida Foundations Frequencies Future Glaucoma Goals Grant Image Individual Institution Latino Least-Squares Analysis Machine Learning Masks Measurement Medical Mentored Patient-Oriented Research Career Development Award Mentors Mentorship Methodology Methods Modeling Monitor Nature Ophthalmology Optical Coherence Tomography Outcome Patient Self-Report Patients Perimetry Physicians Physiologic Intraocular Pressure Population Positioning Attribute Progressive Disease Publications Race Research Research Personnel Resources Risk Risk Factors Science Scientist Self-Help Devices Specialist Statistical Methods Statistical Models Technology Testing Thick Thinness Time Training United States Universities Validation Visit Visual Visual Fields Work career career development clinical care clinical decision-making clinical encounter clinical practice demographics design disability electronic health data experience field study high risk improved indexing individual patient innovation longitudinal care meetings novel patient population personalized predictions population based predictive modeling prevent primary outcome professor programs rapid detection rate of change retinal nerve fiber layer sex skills

项目摘要

PROJECT SUMMARY Swarup S. Swaminathan, MD is an Assistant Professor of Ophthalmology at the Bascom Palmer Eye Institute with a career goal of becoming an independent clinician-scientist in the field of glaucoma clinical research. His overall research focus is to utilize novel statistical and data science methodologies to improve assessment of progression in glaucoma and early detection of those patients at greatest risk for irreversible vision loss. The primary objectives of this K23 career development proposal are: 1) to compare currently available methods used to monitor glaucomatous disease progression with higher-order Bayesian prediction models equipped with data from electronic health records (EHR), and 2) to provide an academic glaucoma specialist with the mentored research experience and formal training to conduct independent clinical research. Achieving these objectives will provide the critical skills required to establish an independent research program focused on applying data science principles to improve the clinical assessment of progression in glaucoma patients. The proposed K23 application will provide valuable mentorship and formal training in biostatistics, analysis of large databases containing longitudinal data, application of Bayesian statistics in the medical sciences, and artificial intelligence and machine learning data analysis. The extensive technical resources available at the Bascom Palmer Eye Institute and University of Miami Institute for Data Science & Computing, the mentorship and expertise of his advisory committee, and the dedicated institutional commitment will provide Dr. Swaminathan with the support needed to transition into an independent clinician-scientist. He will regularly meet with his mentors and advisors to discuss career development, attend pertinent university seminars and workshops, present ongoing research at national meetings, and consistently submit his work for publication. This proposal will test the hypothesis that EHR-equipped Bayesian models outperform ordinary least square (OLS) regression in accuracy and their ability to detect progression earlier. In Aim 1, Bayesian models equipped with EHR population-level imaging and functional data will be constructed to calculate the rate of change in optical coherence tomography and standard automated perimetry metrics of individual patients. In Aim 2, patient- specific risk factor data will be incorporated into Bayesian models to further refine these individualized predictions. These models will be compared to OLS regression, with the hypothesis that Bayesian models will be superior. Finally, in Aim 3, an interactive application will be developed to gather data from clinical practice in order to validate the use of Bayesian models in clinical care. An expert clinician panel will compare masked OLS and Bayesian estimates from these cases. The results of the proposed research will provide the foundation for an R01 grant examining the use of EHR data to improve clinical decision-making for the longitudinal care of glaucoma patients.

项目总结