Core 1: Administration

摘要 对于肺癌P01的成功至关重要，行政核心的总体目标是提供 领导和协调所有科学活动以及财政管理和一般行政 活动，以期最大限度地发挥埃默里大学肺癌P01的综合表现。这个 行政核心将由傅海安博士、苏雷什·拉马林根博士和亚当·马库斯博士领导，他们的不同 在个人和大型多元化企业的成功和生产性管理方面的经验和专业知识 学科研究项目结合了基础研究癌症药理学家的观点和 翻译临床研究人员和LKB1生物学专家，以简化和确保高质量 P01的决策。 行政核心将提供三个不同的具体职能：(1)行政(2)协调(3) 监测和实施。行政职能将包括监督所有项目和核心活动， 财政监督、提供必要的资源、获得和分配机构支助， 编制年度进度报告和其他文件。协调职能将包括规划和 安排每月项目会议和定期顾问委员会会议，聘请顾问委员会 包括患者倡导者在内的成员，协调项目之间、核心之间以及 P01和癌症中心，与NCI项目官员和工作人员沟通和咨询，组织 P01--主办讲座和座谈会。监测和执行工作将包括定期跟踪和 评价所有项目和核心的研究进展和数据质量，执行顾问的 建议，补救表现不佳的项目，并确保遵守所有政府、 NCI，以及当地法规和要求。 在P01执行委员会的指导下，由方案、项目和核心领导人以及 参与的咨询委员会，行政核心将促进方案内的协作和 整合项目和核心，以形成统一的多学科方法，专注于开发我们的 提高对LKB1相关免疫治疗耐药性在肺腺癌和肺癌中的认识 将这些研究转化为当前和未来的治疗机会。

SUMMARY Vital to the success of the Lung Cancer P01, the overall goal of the Administrative Core is to provide leadership and coordination of all scientific activities, as well as fiscal management and general administrative activities in order to maximize the integrated performance of the Emory University Lung Cancer P01. The Administrative Core will be led by Drs. Haian Fu, Suresh Ramalingam and Adam Marcus, whose varied experience and expertise in the successful and productive management of individual and large multi- disciplinary research programs combines the perspectives of a basic research cancer pharmacologist with a translational clinical investigator and an expert in LKB1 biology in order to streamline and ensure high-quality decision-making for the P01. The Administrative Core will provide three distinct specific functions: (1) administration (2) coordination (3) monitoring and implementation. Administrative functions will include oversight of all Project and Core activities, fiscal oversight, provision of the necessary resources, acquisition and allocation of institutional support, preparation of annual progress reports and other documents. Coordination functions will include planning and scheduling of monthly program meetings and regular advisory board meetings, engagement of advisory board members including patient advocates, coordination of interactions between Projects, Cores and between the P01 and the Cancer Center, communication and consultation with NCI project officer and staff, organization of P01-sponsored lectures and symposia. Monitoring and implementation will include regular tracking and evaluation of research progress and data quality for all projects and cores, implementation of advisors’ recommendations, remediation of under-performing projects, and assuring compliance with all governmental, NCI, and local regulations and requirements. Guided by the P01 Executive Committee, comprised of Program, Project and Core leaders, as well as engaged advisory boards, the Administrative Core will facilitate intra-programmatic collaborations and integration of the projects and cores to result in a unified multidisciplinary approach focused on exploiting our improved understanding of LKB1-associated immunotherapy resistance in lung adenocarcinoma and translating these studies into current and future therapeutic opportunities.