Developmental Research Program

发展研究计划

• 批准号: 10210204
• 负责人: HAIAN FU
• 金额: $ 8.98万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-10 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10210204
• 关键词: American Cancer Society; Award; Clinical Research; Collaborations; Development; Evolution; Extramural Activities; Fostering; Foundations; Funding; Future; Goals; Grant; Head and Neck Cancer; Institutes; Institution; Malignant Neoplasms; Malignant neoplasm of lung; Medical; Monitor; Nature; Outcome; Patient Care; Peer Review; Peer Review Grants; Pilot Projects; Process; Program Research Project Grants; Publications; Request for Proposals; Research; Research Personnel; Research Project Grants; Research Proposals; Series; Source; Translational Research; United States National Institutes of Health; Universities; anticancer research; career development; high reward; high risk; innovation; novel; preclinical study; programs; success; translational study

PROJECT SUMMARY/ABSTRACT Emory University’s Lung Cancer SPORE aims to pursue new and innovative research opportunities in the lung cancer field through the implementation of the Developmental Research Program (DRP). The DRP will solicit, evaluate, and fund the most meritorious pilot projects, monitor progress twice annually, and promote the most successful pilot projects into full projects funded by the SPORE and/or other sources. The goals of the DRP are to identify and support meritorious proposals that might expand into full research projects focused on lung cancer in the future, including those of high risk-high reward projects that might otherwise not be funded; to foster collaborative research between Emory investigators and investigators at other institutions; and to enhance translational research in lung cancer by increasing the number of investigators working in this field. The Winship Cancer Institute (Winship) of Emory University has a strong track record in conducting successful pilot project programs. Through the Winship Invest$ program, Winship has awarded 165 pilot grants, with a total of over $7.7M in funding, since 2012. Our track record is illustrated by the DRP in Emory’s head and neck cancer SPORE (funded from 2006-2013) that awarded 17 pilot projects, which evolved into 15 full projects funded by NIH or foundations such as the American Cancer Society and the publication of 34 research articles and 4 review articles. Winship is also a recipient of the ‘Institutional Research Grant’ funded by the American Cancer Society that supports pilot research projects. Specific aims for the DRP are as follows: Aim 1: To solicit research proposals by sending request for proposals (RFP) to all possible applicants at Emory University and other research and medical institutions throughout the state of Georgia; Aim 2: To identify the most outstanding and novel proposals to fund through a clearly defined and well-established review process. Led by a DRP Committee, applications will be reviewed by a panel of leaders of all projects, cores/programs, and other researchers in relevant fields, following NIH review criteria; and Aim 3: To monitor the progress of funded peer-reviewed pilot projects using a series of metrics, including the evolution of projects into major projects (e.g., R01s, full SPORE projects), publications, investigator career development etc. We expect that annually 2 novel projects in basic, translational and clinical studies will be funded, and completion of these high-risk but innovative studies will result in strong publications, additional peer-reviewed grants and the development of a larger and stronger group of investigators focusing on the translational study of lung cancer.

项目概要/摘要 埃默里大学肺癌 SPORE 旨在寻求肺部新的创新研究机会 通过实施发展研究计划（DRP），癌症领域。 DRP 将征求， 评估并资助最有价值的试点项目，每年两次监测进展情况，并推广最有价值的试点项目 将成功的试点项目转化为由 SPORE 和/或其他来源资助的完整项目。 DRP 的目标 是确定并支持有价值的提案，这些提案可能会扩展为专注于肺的完整研究项目 未来的癌症，包括那些否则可能无法获得资助的高风险高回报项目；到 促进埃默里大学研究人员与其他机构的研究人员之间的合作研究；并到 通过增加该领域研究人员的数量来加强肺癌的转化研究。 埃默里大学温希普癌症研究所 (Winship) 在开展成功的癌症治疗方面拥有良好的记录。 试点项目计划。通过 Winship Invest$ 计划，Winship 已授予 165 项试点补助金，其中 自 2012 年以来，融资总额已超过 770 万美元。埃默里大学的 DRP 说明了我们的业绩记录 cancer SPORE（2006-2013 年资助）授予了 17 个试点项目，这些项目后来发展为 15 个完整项目 由 NIH 或美国癌症协会等基金会资助并发表 34 篇研究论文 和4篇评论文章。 Winship 也是美国资助的“机构研究补助金”的获得者 支持试点研究项目的癌症协会。 DRP 的具体目标如下： 目标 1： 通过向埃默里大学所有可能的申请人发送提案请求 (RFP) 来征求研究提案 佐治亚州各地的大学和其他研究和医疗机构；目标 2：确定 通过明确定义和完善的审查流程来资助最杰出和新颖的提案。 在 DRP 委员会的领导下，申请将由所有项目、核心/计划、 以及相关领域的其他研究人员，遵循 NIH 审查标准；目标 3：监测进展情况 使用一系列指标资助同行评审的试点项目，包括项目演变为主要项目 项目（例如，R01、完整的 SPORE 项目）、出版物、研究者职业发展等。我们期望 每年将资助2个基础、转化和临床研究的新项目，并完成这些项目 高风险但创新的研究将产生强有力的出版物、额外的同行评审资助和 培养更多、更强的研究人员，专注于肺癌的转化研究。