Developmental Research Program

发展研究计划

• 批准号: 10685427
• 负责人: HAIAN FU
• 金额: $ 7.68万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-10 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10685427
• 关键词: American Cancer Society; Award; Clinical Research; Collaborations; Development; Evolution; Extramural Activities; Fostering; Foundations; Funding; Future; Goals; Grant; Head and Neck Cancer; Institution; Investments; Malignant Neoplasms; Malignant neoplasm of lung; Medical; Monitor; Nature; Outcome; Patient Care; Peer Review; Peer Review Grants; Pilot Projects; Process; Program Research Project Grants; Publications; Request for Proposals; Research; Research Personnel; Research Project Grants; Research Proposals; Series; Source; Translational Research; United States National Institutes of Health; Universities; anticancer research; career development; high reward; high risk; innovation; novel; preclinical study; programs; success; translational study

PROJECT SUMMARY/ABSTRACT Emory University’s Lung Cancer SPORE aims to pursue new and innovative research opportunities in the lung cancer field through the implementation of the Developmental Research Program (DRP). The DRP will solicit, evaluate, and fund the most meritorious pilot projects, monitor progress twice annually, and promote the most successful pilot projects into full projects funded by the SPORE and/or other sources. The goals of the DRP are to identify and support meritorious proposals that might expand into full research projects focused on lung cancer in the future, including those of high risk-high reward projects that might otherwise not be funded; to foster collaborative research between Emory investigators and investigators at other institutions; and to enhance translational research in lung cancer by increasing the number of investigators working in this field. The Winship Cancer Institute (Winship) of Emory University has a strong track record in conducting successful pilot project programs. Through the Winship Invest$ program, Winship has awarded 165 pilot grants, with a total of over $7.7M in funding, since 2012. Our track record is illustrated by the DRP in Emory’s head and neck cancer SPORE (funded from 2006-2013) that awarded 17 pilot projects, which evolved into 15 full projects funded by NIH or foundations such as the American Cancer Society and the publication of 34 research articles and 4 review articles. Winship is also a recipient of the ‘Institutional Research Grant’ funded by the American Cancer Society that supports pilot research projects. Specific aims for the DRP are as follows: Aim 1: To solicit research proposals by sending request for proposals (RFP) to all possible applicants at Emory University and other research and medical institutions throughout the state of Georgia; Aim 2: To identify the most outstanding and novel proposals to fund through a clearly defined and well-established review process. Led by a DRP Committee, applications will be reviewed by a panel of leaders of all projects, cores/programs, and other researchers in relevant fields, following NIH review criteria; and Aim 3: To monitor the progress of funded peer-reviewed pilot projects using a series of metrics, including the evolution of projects into major projects (e.g., R01s, full SPORE projects), publications, investigator career development etc. We expect that annually 2 novel projects in basic, translational and clinical studies will be funded, and completion of these high-risk but innovative studies will result in strong publications, additional peer-reviewed grants and the development of a larger and stronger group of investigators focusing on the translational study of lung cancer.

项目摘要/摘要 埃默里大学的肺癌孢子旨在在肺中购买新的创新研究机会 通过实施发展研究计划（DRP）的癌症领域。 DRP将征求， 评估并资助最有功的飞行员项目，每年两次监视进度，并提升最多 成功的试点项目进入由孢子和/或其他来源资助的完整项目。 DRP的目标 是要识别和支持可能扩展到专注于肺部的完整研究项目的功绩提案 将来的癌症，包括可能没有资助的高风险高奖励项目的癌症； 促进其他机构的Emory研究者与研究人员之间的合作研究；然后 通过增加该领域的研究人员数量来增强肺癌的转化研究。 埃默里大学（Emory University）的Winship Cancer Institute（Winship）在取得成功方面有着良好的记录 试点项目计划。通过Winship Invest $计划，Winship授予了165个飞行员赠款， 自2012年以来，总计超过770万美元的资金。 癌症孢子（从2006 - 2013年资助）授予了17个试点项目，该项目演变为15个完整项目 由NIH或美国癌症协会等基金会资助以及34条研究文章的出版 和4篇评论文章。 Winship还是美国人资助的“机构研究赠款”的获得者 支持试点研究项目的癌症协会。 DRP的具体目标如下：目标1： 通过向Emory的所有可能申请人发送提案请求（RFP）来征求研究建议 整个佐治亚州的大学和其他研究和医疗机构；目标2：确定 大多数杰出和新颖的建议通过明确定义且公认的审查过程提供资金。 由DRP委员会领导，申请将由所有项目，核心/计划的领导者小组审查 以及相关领域的其他研究人员，遵循NIH审查标准；和目标3：监视进度 使用一系列指标进行了资助的同行评审的试点项目，包括项目的演变为主要 项目（例如R01，完整的孢子项目），出版物，调查员职业发展等。我们希望 基础，翻译和临床研究中的两个新型项目将得到资助，并完成这些项目 高风险但创新的研究将导致强大的出版物，额外的同行评审赠款以及 开发更大，更强大的研究人员，专注于肺癌的转化研究。