Activation of TERT gene expression in breast carcinogenesis

大多数癌症发展的一个关键步骤是端粒酶的开启，端粒酶允许癌细胞无限制地生长。我们将使用在实验室中培养的人类乳腺细胞基因组功能分析的新技术来研究这一步骤的分子细节。阻断端粒酶在癌症治疗方面具有巨大的潜力，因此分析这种酶是如何被激活的，可能会找到治疗乳腺癌和其他癌症的新策略。

A key step in the development of most cancers is the switching on of an enzyme, telomerase, that allows cancer cells to keep growing without limit. We will study the molecular details of this step using new techniques for functional analyses of the genome in human breast cells grown in the laboratory. Blocking telomerase has great potential for cancer treatment, so analysing how this enzyme gets switched on may identify new strategies for achieving this for breast cancer - and other cancers.