Telomere structural abnormalities in cells using Alternative Lengthening of Telomeres

使用端粒替代延长技术观察细胞端粒结构异常

• 批准号: nhmrc : 1009231
• 负责人: A/Pr Hilda Pickett
• 金额: $ 34.82万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/telomere-structural-abnormalities-lengthening-telomeres/109385
• 关键词: Telomere; structural; abnormalities; cells; using

The continuing growth of cancers depends on their cells being able to prevent shortening of chromosome ends (telomeres). Some cancers, including very aggressive brain and connective tissue tumours, achieve this via the Alternative Lengthening of Telomeres (ALT) process. We have evidence that the telomere structure of normal cells prevents ALT. Here we will examine how the telomere structure of ALT-positive cancer cells is changed, and whether reversing these changes inhibits ALT.

癌症的持续生长取决于它们的细胞能够阻止染色体末端（端粒）的缩短。一些癌症，包括非常侵袭性的脑和结缔组织肿瘤，通过端粒替代性延长（ALT）过程实现这一点。我们有证据表明正常细胞的端粒结构可以预防ALT。在这里，我们将研究ALT阳性癌细胞的端粒结构是如何改变的，以及逆转这些变化是否会抑制ALT。