The TERT locus as a susceptibility gene for ovarian and breast cancer: genetic and functional evaluation

TERT 位点作为卵巢癌和乳腺癌的易感基因：遗传和功能评估

• 批准号: nhmrc : 1012023
• 负责人: A/Pr Hilda Pickett
• 金额: $ 26.31万
• 依托单位: Queensland Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/tert-locus-susceptibility-functional-evaluation/109632
• 关键词: TERT; locus; susceptibility; gene; ovarian

Breast and ovarian cancer, which are among the commonest cancers in Australian women, share similar causes. We have found that a gene involved in maintaining the ends of chromosomes increases risk of ovarian cancer. The project aims to explore this further, and also to determine whether it also increases risk of breast cancer.

乳腺癌和卵巢癌是澳大利亚妇女最常见的癌症之一，其病因相似。我们已经发现，一个参与维持染色体末端的基因会增加患卵巢癌的风险。该项目旨在进一步探索这一点，并确定它是否也会增加患乳腺癌的风险。