Association of Combined Metals and PFAS with Cardiovascular Disease Risk.
Association of Combined Metals and PFAS with Cardiovascular Disease Risk.
复制标题
DOI：
10.3390/toxics11120979
复制
发表时间：
2023-12-01
期刊：
影响因子：
4.6
通讯作者：
Obeng-Gyasi E
中科院分区：
文献类型：
--
作者：
Boafo YS;Mostafa S;Obeng-Gyasi E
本研究旨在调查暴露于金属和全氟和多氟烷基物质（PFAS）对心血管疾病（CVD）相关风险的影响。PFASs，包括PFOA，PFOS，PFNA和PFHxS，以及铅（Pb），镉（Cd）和汞（Hg）等金属，进行了分析，以阐明其对CVD风险的综合影响。研究方法：利用2007年至2014年国家健康和营养调查（NHANES）的数据，这项调查探讨了PFASs和金属对CVD风险的影响。检查了个体CVD标志物的谱，包括收缩压（SBP）、舒张压（DBP）、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）、总胆固醇和甘油三酯。此外，还评估了综合CVD风险指数，即总体心血管生物标志物指数（OCBI），包括Fragrance风险评分和总体心血管指数。采用线性回归分析探讨这些变量之间的关系。此外，为了评估暴露混合物和CVD之间的剂量-反应关系，同时减轻多重共线性和潜在相互作用效应的影响，采用贝叶斯核机器回归（BKMR）。结果如下：我们的研究结果表明，暴露于PFAS和金属的组合增加了CVD的风险，与铅发生的组合带来了许多CVD相关标志物中的最大影响。结论：这项研究发现，金属和PFAS的联合暴露显着提高了CVD风险的可能性。这些结果强调了了解多污染物暴露之间复杂的相互作用及其对心血管健康的潜在影响的重要性。
This study sought to investigate the impact of exposure to metals and per- and polyfluoroalkyl substances (PFASs) on cardiovascular disease (CVD)-related risk. PFASs, including PFOA, PFOS, PFNA, and PFHxS, as well as metals such as lead (Pb), cadmium (Cd), and mercury (Hg), were analyzed to elucidate their combined effects on CVD risk. Methods: Utilizing data from the National Health and Nutrition Examination Survey (NHANES) spanning from 2007 to 2014, this investigation explored the effects of PFASs and metals on CVD risk. A spectrum of individual CVD markers, encompassing systolic blood pressure (SBP), diastolic blood pressure (DBP), high-density lipoprotein (HDL), low-density lipoprotein (LDL), total cholesterol, and triglycerides, was examined. Additionally, comprehensive CVD risk indices were evaluated, namely the Overall Cardiovascular Biomarkers Index (OCBI), including the Framingham Risk Score and an Overall Cardiovascular Index. Linear regression analysis was employed to probe the relationships between these variables. Furthermore, to assess dose–response relationships between exposure mixtures and CVD while mitigating the influence of multicollinearity and potential interaction effects, Bayesian Kernel Machine Regression (BKMR) was employed. Results: Our findings indicated that exposure to PFAS and metals in combination increased CVD risk, with combinations occurring with lead bringing forth the largest impact among many CVD-related markers. Conclusions: This study finds that combined exposure to metals and PFASs significantly elevates the likelihood of CVD risk. These results highlight the importance of understanding the complex interplay between multipollutant exposures and their potential implications for cardiovascular health.
登录
查看更多内容
DOI：
10.1007/s00420-013-0891-8
发表时间：
2014-07-01
影响因子：
3
作者：
Eom, Sang-Yong;Choi, Sun-Hee;Park, Jung-Duck
通讯作者：
Park, Jung-Duck
DOI：
10.1016/s0946-672x(04)80028-2
发表时间：
2004-01-01
影响因子：
3.5
作者：
Kobal, Alfred B.;Horvat, Milena;Osredkar, Josko
通讯作者：
Osredkar, Josko
影响因子：
2.9
作者：
Alissa EM;Ferns GA
通讯作者：
Ferns GA
影响因子：
120.7
作者：
Hu, H;Aro, A;Rotnitzky, A
通讯作者：
Rotnitzky, A
影响因子：
6.1
作者：
KISHIMOTO, T;OGURI, T;TADA, M
通讯作者：
TADA, M