Peripheral and central contributions to auditory temporal processing deficits and speech understanding in older cochlear implantees

外周和中枢对老年人工耳蜗植入者听觉时间处理缺陷和言语理解的贡献

• 批准号: 10630111
• 负责人: Matthew J. Goupell
• 金额: $ 56.07万
• 依托单位: UNIV OF MARYLAND, COLLEGE PARK
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10630111
• 关键词: Accounting; Acoustic Nerve; Acoustics; Action Potentials; Adult; Affect; Age; Aging; Auditory; Auditory area; Biological; Bionics; Brain Stem; Bypass; Cochlea; Cochlear Implants; Cognitive; Communication; Compensation; Complex; Cueing for speech; Effectiveness; Elderly; Electric Stimulation; Electrodes; Electrophysiology (science); Generations; Goals; Grant; Hearing; Individual; Intervention; Knowledge; Language; Link; Location; Measurement; Measures; Mission; National Institute on Deafness and Other Communication Disorders; Outcome; Perception; Performance; Peripheral; Play; Presbycusis; Public Health; Quality of life; Rehabilitation therapy; Research; Role; Scanning; Signal Transduction; Speech; Speech Perception; Stimulus; Technology; Testing; United States National Institutes of Health; X-Ray Computed Tomography; age effect; age related; aging auditory system; auditory processing; baby boomer; design; disability; effectiveness evaluation; electric impedance; experimental study; hearing impairment; hearing restoration; improved; innovation; neural; remediation; simulation; speech accuracy; young adult

This research aims to understand age-related temporal processing in older cochlear-implant (CI) users. The gap in knowledge is that critical measurements and comparisons have been unavailable to disentangle peripheral from central factors that impact CI performance. The long-term goals of this grant are to (1) understand the biological effects of auditory aging and (2) determine how to best remediate age-related auditory deficits with a CI. The overall objective of this application, which is the next step toward attainment of our long-term goals, is to disentangle the peripheral and central contributions to age-related temporal processing deficits in CI users. Our central hypothesis is that age-related speech perception deficits are explained by unique contributions from pe- ripheral and central auditory functions, which significantly affect outcomes in older CI users. The rationale is that CIs are uniquely suited to disentangle peripheral vs central contributions of age-related temporal processing deficits because they can bypass or easily characterize peripheral contributions to hearing, making an ideal system for auditory aging research. We plan to test our central hypothesis by pursuing the following specific aims: (1) Determine the extent to which temporal processing from single-electrode stimulation can be explained by aging and the peripheral electrode-to-neural interface in CI subjects; (2) Determine the extent to which speech perception can be explained by aging and the peripheral electrode-to-neural interface in CI subjects; (3) Deter- mine the extent and manner in which central auditory compensation overcomes peripheral processing deficits that contribute to age-related performance declines in CI subjects. These aims will yield the following expected outcomes. First, we will understand how aging and ENI correlate with each other, and how well peripheral con- tributions explain simple single-electrode temporal-processing performance. Second, we will understand if pe- ripheral contributions play a smaller role in explaining speech perception performance using multi-electrode stim- ulation, relative to perception of simple signals presented to single electrodes. Third, we will ascertain if age- related central processing deficits contribute above and beyond the peripheral deficits for processing of both simple and complex acoustic signals (including speech) among CI listeners. The proposed research is significant because expanding our understanding of the locus of the age-related temporal processing deficits will help de- velop age-specific guidance to CI candidacy, approaches to CI programming, and CI rehabilitation, improving an older CI user’s performance and quality of life. The proposed research is innovative because CIs offer a unique ability to bypass and characterize the periphery, allowing us to disentangle peripheral vs central mecha- nisms that contribute to age-related hearing deficits.

本研究旨在了解老年人工耳蜗（CI）使用者年龄相关的时间加工。的差距

项目成果

Stimulus context affects the phonemic categorization of temporally based word contrasts in adult cochlear-implant users.

刺激环境会影响成年人工耳蜗使用者基于时间的单词对比的音位分类。

• DOI: 10.1121/10.0009838
• 发表时间: 2022
• 期刊: The Journal of the Acoustical Society of America
• 作者: Xie,Zilong;Anderson,Samira;Goupell,MatthewJ
• 通讯作者: Goupell,MatthewJ

Effect of Chronological Age on Pulse Rate Discrimination in Adult Cochlear-Implant Users.

年代年龄对成人人工耳蜗使用者脉搏率歧视的影响。

• DOI: 10.1177/23312165211007367
• 发表时间: 2021-01
• 期刊: Trends in hearing
• 影响因子: 2.7
• 作者: Johnson KC;Xie Z;Shader MJ;Mayo PG;Goupell MJ
• 通讯作者: Goupell MJ

Letter to the Editor: Possible Sex Effects on the Processing of Temporal Cues in Word Segments in Adult Cochlear-Implant Users.

致编辑的信：性别对成年人工耳蜗用户处理词段中的时间线索可能产生的影响。

• DOI: 10.1177/2331216520946675
• 发表时间: 2020
• 期刊: Trends in hearing
• 影响因子: 2.7
• 作者: Xie,Zilong;Shader,MaureenJ;Gordon-Salant,Sandra;Anderson,Samira;Goupell,MatthewJ
• 通讯作者: Goupell,MatthewJ

Accuracy and cue use in word segmentation for cochlear-implant listeners and normal-hearing listeners presented vocoded speech.

人工耳蜗听众和正常听力听众呈现声码语音的分词准确性和提示使用。

• DOI: 10.1121/10.0006448
• 发表时间: 2021
• 期刊: The Journal of the Acoustical Society of America
• 作者: Heffner,ChristopherC;Jaekel,BrittanyN;Newman,RochelleS;Goupell,MatthewJ
• 通讯作者: Goupell,MatthewJ