Peripheral and central contributions to auditory temporal processing deficits and speech understanding in older cochlear implantees
外周和中枢对老年人工耳蜗植入者听觉时间处理缺陷和言语理解的贡献
基本信息
- 批准号:10444172
- 负责人:
- 金额:$ 56.3万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-04-01 至 2027-03-31
- 项目状态:未结题
- 来源:
- 关键词:AccountingAcoustic NerveAcousticsAction PotentialsAdultAffectAgeAgingAuditoryAuditory areaBiologicalBionicsBrain StemBypassCochleaCochlear ImplantsCognitiveComplexCueing for speechEffectivenessElderlyElectric StimulationElectrodesElectrophysiology (science)Financial compensationGenerationsGoalsGrantHearingIndividualInterventionKnowledgeLanguageLinkLocationMeasurementMeasuresMissionNational Institute on Deafness and Other Communication DisordersOutcomePerceptionPerformancePeripheralPlayPresbycusisPublic HealthQuality of lifeRehabilitation therapyResearchRoleScanningSignal TransductionSpeechSpeech PerceptionStimulusTechnologyTestingUnited States National Institutes of HealthX-Ray Computed Tomographyage effectage relatedaging auditory systemauditory processingbaby boomerbasedesigndisabilityeffectiveness evaluationelectric impedanceexperimental studyhearing impairmenthearing restorationimprovedinnovationrelating to nervous systemsimulationspeech accuracyyoung adult
项目摘要
This research aims to understand age-related temporal processing in older cochlear-implant (CI) users. The gap
in knowledge is that critical measurements and comparisons have been unavailable to disentangle peripheral
from central factors that impact CI performance. The long-term goals of this grant are to (1) understand the
biological effects of auditory aging and (2) determine how to best remediate age-related auditory deficits with a
CI. The overall objective of this application, which is the next step toward attainment of our long-term goals, is to
disentangle the peripheral and central contributions to age-related temporal processing deficits in CI users. Our
central hypothesis is that age-related speech perception deficits are explained by unique contributions from pe-
ripheral and central auditory functions, which significantly affect outcomes in older CI users. The rationale is that
CIs are uniquely suited to disentangle peripheral vs central contributions of age-related temporal processing
deficits because they can bypass or easily characterize peripheral contributions to hearing, making an ideal
system for auditory aging research. We plan to test our central hypothesis by pursuing the following specific
aims: (1) Determine the extent to which temporal processing from single-electrode stimulation can be explained
by aging and the peripheral electrode-to-neural interface in CI subjects; (2) Determine the extent to which speech
perception can be explained by aging and the peripheral electrode-to-neural interface in CI subjects; (3) Deter-
mine the extent and manner in which central auditory compensation overcomes peripheral processing deficits
that contribute to age-related performance declines in CI subjects. These aims will yield the following expected
outcomes. First, we will understand how aging and ENI correlate with each other, and how well peripheral con-
tributions explain simple single-electrode temporal-processing performance. Second, we will understand if pe-
ripheral contributions play a smaller role in explaining speech perception performance using multi-electrode stim-
ulation, relative to perception of simple signals presented to single electrodes. Third, we will ascertain if age-
related central processing deficits contribute above and beyond the peripheral deficits for processing of both
simple and complex acoustic signals (including speech) among CI listeners. The proposed research is significant
because expanding our understanding of the locus of the age-related temporal processing deficits will help de-
velop age-specific guidance to CI candidacy, approaches to CI programming, and CI rehabilitation, improving
an older CI user’s performance and quality of life. The proposed research is innovative because CIs offer a
unique ability to bypass and characterize the periphery, allowing us to disentangle peripheral vs central mecha-
nisms that contribute to age-related hearing deficits.
本研究旨在了解老年人工耳蜗者与年龄相关的时间加工。差距
在知识中,关键测量和比较一直无法用于解开外围设备
来自影响CI绩效的核心因素。这笔赠款的长期目标是:(1)了解
听觉老化的生物学效应以及(2)确定如何最好地通过
线人。这项申请的总体目标是实现我们的长期目标的下一步,即
理清CI使用者与年龄相关的时间加工缺陷的外周和中枢作用。我们的
中心假说是,与年龄相关的言语知觉障碍是由年龄相关的言语知觉障碍的独特贡献来解释的。
外周和中枢听觉功能,这对老年CI使用者的预后有显著影响。理由是
CI独一无二地适合于分离年龄相关的时间加工的外周和中枢贡献
缺陷,因为它们可以绕过或容易地表征外周对听力的贡献,使理想的
用于听觉老化研究的系统。我们计划通过追求以下具体内容来测试我们的中心假设
目的:(1)确定可以在多大程度上解释单电极刺激的时间加工
通过脑梗塞受试者的衰老和外周电极到神经的接口;(2)确定言语的程度
认知可以通过衰老和外周电极-神经接口来解释;(3)阻止-
挖掘中枢听觉代偿克服外周加工缺陷的程度和方式
这导致了CI受试者与年龄相关的表现下降。这些目标将产生以下预期结果
结果。首先,我们将了解老龄化与弹性网卡之间的关联,以及外围设备连接的情况。
贡献解释了简单的单电极时间加工性能。其次,我们会理解如果PE-
外周贡献在解释多电极刺激下的言语知觉表现中的作用较小。
调制,相对于对呈现给单个电极的简单信号的感知。第三,我们会确定年龄是否-
相关的中央加工缺陷的贡献超过了加工两者的外周缺陷
CI听者之间的简单和复杂的声音信号(包括语音)。这项拟议的研究具有重要意义
因为扩大我们对与年龄相关的时间加工缺陷的理解将有助于消除年龄相关的时间加工缺陷。
为CI候选人、CI规划方法和CI康复提供特定年龄的指导,改进
较老的CI用户的表现和生活质量。拟议的研究是创新的,因为独联体提供了
独特的绕过和表征外围设备的能力,使我们能够将外围设备与中央机械设备分开-
导致与年龄相关的听力障碍的神经症。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Matthew J. Goupell其他文献
Matthew J. Goupell的其他文献
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{{ truncateString('Matthew J. Goupell', 18)}}的其他基金
UMD-REACH (Research Equity and Access in Communication and Hearing)
UMD-REACH(沟通和听证方面的研究公平和访问)
- 批准号:
10707795 - 财政年份:2023
- 资助金额:
$ 56.3万 - 项目类别:
Peripheral and central contributions to auditory temporal processing deficits and speech understanding in older cochlear implantees
外周和中枢对老年人工耳蜗植入者听觉时间处理缺陷和言语理解的贡献
- 批准号:
10630111 - 财政年份:2022
- 资助金额:
$ 56.3万 - 项目类别:
Binaural unmasking of tones and speech in bilateral cochlear implantees
双侧人工耳蜗植入者的双耳揭示音调和言语
- 批准号:
9177103 - 财政年份:2016
- 资助金额:
$ 56.3万 - 项目类别:
Temporal processing and speech understanding in older cochlear implantees
老年人工耳蜗植入者的时间处理和言语理解
- 批准号:
9355563 - 财政年份:2016
- 资助金额:
$ 56.3万 - 项目类别:
Temporal processing and speech understanding in older cochlear implantees
老年人工耳蜗植入者的时间处理和言语理解
- 批准号:
9915828 - 财政年份:2016
- 资助金额:
$ 56.3万 - 项目类别:
Binaural unmasking of tones and speech in bilateral cochlear implantees
双侧人工耳蜗植入者的双耳揭示音调和言语
- 批准号:
9281725 - 财政年份:2016
- 资助金额:
$ 56.3万 - 项目类别:
Speech understanding and signal detection in noise in bilateral cochlear implants
双侧人工耳蜗噪声中的语音理解和信号检测
- 批准号:
8516493 - 财政年份:2011
- 资助金额:
$ 56.3万 - 项目类别:
Speech understanding and signal detection in noise in bilateral cochlear implants
双侧人工耳蜗噪声中的语音理解和信号检测
- 批准号:
8292330 - 财政年份:2011
- 资助金额:
$ 56.3万 - 项目类别:
Speech understanding and signal detection in noise in bilateral cochlear implants
双侧人工耳蜗噪声中的语音理解和信号检测
- 批准号:
8325734 - 财政年份:2011
- 资助金额:
$ 56.3万 - 项目类别:
Speech understanding and signal detection in noise in bilateral cochlear implants
双侧人工耳蜗噪声中的语音理解和信号检测
- 批准号:
7712963 - 财政年份:2009
- 资助金额:
$ 56.3万 - 项目类别: