Peripheral and central contributions to auditory temporal processing deficits and speech understanding in older cochlear implantees
外周和中枢对老年人工耳蜗植入者听觉时间处理缺陷和言语理解的贡献
基本信息
- 批准号:10444172
- 负责人:
- 金额:$ 56.3万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-04-01 至 2027-03-31
- 项目状态:未结题
- 来源:
- 关键词:AccountingAcoustic NerveAcousticsAction PotentialsAdultAffectAgeAgingAuditoryAuditory areaBiologicalBionicsBrain StemBypassCochleaCochlear ImplantsCognitiveComplexCueing for speechEffectivenessElderlyElectric StimulationElectrodesElectrophysiology (science)Financial compensationGenerationsGoalsGrantHearingIndividualInterventionKnowledgeLanguageLinkLocationMeasurementMeasuresMissionNational Institute on Deafness and Other Communication DisordersOutcomePerceptionPerformancePeripheralPlayPresbycusisPublic HealthQuality of lifeRehabilitation therapyResearchRoleScanningSignal TransductionSpeechSpeech PerceptionStimulusTechnologyTestingUnited States National Institutes of HealthX-Ray Computed Tomographyage effectage relatedaging auditory systemauditory processingbaby boomerbasedesigndisabilityeffectiveness evaluationelectric impedanceexperimental studyhearing impairmenthearing restorationimprovedinnovationrelating to nervous systemsimulationspeech accuracyyoung adult
项目摘要
This research aims to understand age-related temporal processing in older cochlear-implant (CI) users. The gap
in knowledge is that critical measurements and comparisons have been unavailable to disentangle peripheral
from central factors that impact CI performance. The long-term goals of this grant are to (1) understand the
biological effects of auditory aging and (2) determine how to best remediate age-related auditory deficits with a
CI. The overall objective of this application, which is the next step toward attainment of our long-term goals, is to
disentangle the peripheral and central contributions to age-related temporal processing deficits in CI users. Our
central hypothesis is that age-related speech perception deficits are explained by unique contributions from pe-
ripheral and central auditory functions, which significantly affect outcomes in older CI users. The rationale is that
CIs are uniquely suited to disentangle peripheral vs central contributions of age-related temporal processing
deficits because they can bypass or easily characterize peripheral contributions to hearing, making an ideal
system for auditory aging research. We plan to test our central hypothesis by pursuing the following specific
aims: (1) Determine the extent to which temporal processing from single-electrode stimulation can be explained
by aging and the peripheral electrode-to-neural interface in CI subjects; (2) Determine the extent to which speech
perception can be explained by aging and the peripheral electrode-to-neural interface in CI subjects; (3) Deter-
mine the extent and manner in which central auditory compensation overcomes peripheral processing deficits
that contribute to age-related performance declines in CI subjects. These aims will yield the following expected
outcomes. First, we will understand how aging and ENI correlate with each other, and how well peripheral con-
tributions explain simple single-electrode temporal-processing performance. Second, we will understand if pe-
ripheral contributions play a smaller role in explaining speech perception performance using multi-electrode stim-
ulation, relative to perception of simple signals presented to single electrodes. Third, we will ascertain if age-
related central processing deficits contribute above and beyond the peripheral deficits for processing of both
simple and complex acoustic signals (including speech) among CI listeners. The proposed research is significant
because expanding our understanding of the locus of the age-related temporal processing deficits will help de-
velop age-specific guidance to CI candidacy, approaches to CI programming, and CI rehabilitation, improving
an older CI user’s performance and quality of life. The proposed research is innovative because CIs offer a
unique ability to bypass and characterize the periphery, allowing us to disentangle peripheral vs central mecha-
nisms that contribute to age-related hearing deficits.
本研究旨在了解年龄相关的时间处理在老年耳蜗植入(CI)用户。差距
在知识是关键的测量和比较一直无法解开周边
影响CI绩效的核心因素。该补助金的长期目标是(1)了解
听觉老化的生物学效应和(2)确定如何最好地修复与年龄相关的听觉缺陷,
CI.本申请的总体目标是实现我们长期目标的下一步,
解开周边和中央贡献的年龄相关的时间处理缺陷CI用户。我们
中心假设是,年龄相关的言语知觉缺陷是由来自PE的独特贡献解释的,
边缘和中枢听觉功能,这显著影响老年CI使用者的结果。基本原理是
CI是唯一适合于解开与年龄相关的时间处理的周边与中央的贡献
缺陷,因为它们可以绕过或容易地表征对听力的外围贡献,
听觉老化研究系统。我们计划通过以下具体步骤来检验我们的中心假设:
目的:(1)确定单电极刺激的时间加工可以解释的程度
通过年龄和CI受试者的外周电极-神经界面;(2)确定言语
知觉可以用年龄和CI受试者的外周电极-神经界面来解释;(3)阻止-
挖掘中枢听觉补偿克服周边处理缺陷的程度和方式
导致CI受试者与年龄相关的表现下降。这些目标将产生以下预期结果:
结果。首先,我们将了解衰老和ENI如何相互关联,以及外周神经系统如何相互关联。
贡献解释了简单的单电极时间处理性能。第二,我们会理解,如果PE-
ripheral贡献在解释使用多电极刺激的言语感知性能中起较小的作用,
相对于对呈现给单个电极的简单信号的感知,第三,我们要确定年龄-
相关的中央处理缺陷的贡献超过周边缺陷的处理,
简单和复杂的声学信号(包括语音)。所提出的研究是有意义的
因为扩大我们对与年龄相关的时间处理缺陷的理解将有助于
对CI候选人的年龄特定指导,CI编程方法和CI康复,改善
老年CI用户的表现和生活质量。拟议的研究是创新的,因为CI提供了一个
独特的能力,绕过和表征外围,使我们能够解开外围与中央机制,
导致与年龄相关的听力缺陷的寄生虫。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Matthew J. Goupell其他文献
Matthew J. Goupell的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Matthew J. Goupell', 18)}}的其他基金
UMD-REACH (Research Equity and Access in Communication and Hearing)
UMD-REACH(沟通和听证方面的研究公平和访问)
- 批准号:
10707795 - 财政年份:2023
- 资助金额:
$ 56.3万 - 项目类别:
Peripheral and central contributions to auditory temporal processing deficits and speech understanding in older cochlear implantees
外周和中枢对老年人工耳蜗植入者听觉时间处理缺陷和言语理解的贡献
- 批准号:
10630111 - 财政年份:2022
- 资助金额:
$ 56.3万 - 项目类别:
Binaural unmasking of tones and speech in bilateral cochlear implantees
双侧人工耳蜗植入者的双耳揭示音调和言语
- 批准号:
9177103 - 财政年份:2016
- 资助金额:
$ 56.3万 - 项目类别:
Temporal processing and speech understanding in older cochlear implantees
老年人工耳蜗植入者的时间处理和言语理解
- 批准号:
9355563 - 财政年份:2016
- 资助金额:
$ 56.3万 - 项目类别:
Temporal processing and speech understanding in older cochlear implantees
老年人工耳蜗植入者的时间处理和言语理解
- 批准号:
9915828 - 财政年份:2016
- 资助金额:
$ 56.3万 - 项目类别:
Binaural unmasking of tones and speech in bilateral cochlear implantees
双侧人工耳蜗植入者的双耳揭示音调和言语
- 批准号:
9281725 - 财政年份:2016
- 资助金额:
$ 56.3万 - 项目类别:
Speech understanding and signal detection in noise in bilateral cochlear implants
双侧人工耳蜗噪声中的语音理解和信号检测
- 批准号:
8516493 - 财政年份:2011
- 资助金额:
$ 56.3万 - 项目类别:
Speech understanding and signal detection in noise in bilateral cochlear implants
双侧人工耳蜗噪声中的语音理解和信号检测
- 批准号:
8292330 - 财政年份:2011
- 资助金额:
$ 56.3万 - 项目类别:
Speech understanding and signal detection in noise in bilateral cochlear implants
双侧人工耳蜗噪声中的语音理解和信号检测
- 批准号:
8325734 - 财政年份:2011
- 资助金额:
$ 56.3万 - 项目类别:
Speech understanding and signal detection in noise in bilateral cochlear implants
双侧人工耳蜗噪声中的语音理解和信号检测
- 批准号:
7712963 - 财政年份:2009
- 资助金额:
$ 56.3万 - 项目类别: