Control and Prevention of Zoonotic Epidemics in Cities: A Socio-Spatial Approach

城市人畜共患流行病的控制和预防：社会空间方法

• 批准号: 10629256
• 负责人: Ricardo Castillo Neyra
• 金额: $ 13.08万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-06-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10629256
• 关键词: Affect; Algorithms; Animals; Area; Behavior; Biological Models; Canis familiaris; Cities; Communities; Complex; Data; Disease; Domestic Animals; Ecology; Environment; Epidemic; Failure; Focus Groups; Geography; Health; Health Services; Health behavior; Heterogeneity; Human; Individual; Interview; Latin America; Location; Logistic Regressions; Mass Vaccinations; Mathematics; Measures; Methodology; Methods; Modeling; Movement; Peru; Population; Population Density; Population Dynamics; Population Heterogeneity; Prevention; Public Health; RNA Interference; Rabies; Rabies Vaccines; Rabies virus; Research; Risk Reduction; Role; Rural; Rural Community; Seasonal Variations; Statistical Models; Surveys; Testing; United States Public Health Service; Urban Population; Urbanization; Vaccinated; Vaccination; Vaccines; Variant; Work; Zoonoses; community-level factor; design; disorder control; epidemic response; experience; experimental study; feasibility testing; health service use; improved; infection risk; innovation; interdisciplinary approach; mathematical algorithm; mathematical model; member; migration; multidisciplinary; novel strategies; pathogen; prevent; programs; social; social determinants; social factors; transmission process; unvaccinated; uptake; urban area; urban setting; vaccine acceptance; viral transmission

Project Summary Zoonotic diseases present unique challenges for public health due to the complex interactions between humans, animals, pathogens, and the environment. Urbanization, migration, and the urban landscape add additional layers of complexity to these interactions, and the control and prevention of zoonotic pathogens requires innovative multidisciplinary methodological approaches that take into account social, spatial and population dynamics in urban areas. Epidemics of zoonotic pathogens are ongoing in major urban centers across Latin America and worldwide, and among them, the city of Arequipa, Peru is in the midst of a canine rabies epidemic. The drivers of this epidemic work at many levels: Individual- and community-level factors, including social determinants, may explain the currently low vaccination rate of domestic animals against rabies. Urban geography can also affect participation in zoonotic disease control programs, facilitating the emergence of canine rabies and complicating its control. Free-roaming owned and stray dogs with their unique ecology and population dynamics could also impact the results of control activities. In this proposal I will develop a new approach for the control and prevention of zoonotic disease in cities that integrates mathematical and social approaches, using rabies as a model zoonotic disease strongly determined by urban dynamics. Following the urban re-emergence after 15 years, the Ministry of Health has failed to quell the rabies epidemic in Arequipa's complex urban environment. I hypothesize that the failure is due primarily to three factors: 1) Poorly understood determinants of canine vaccination uptake; 2) Ignored spatial heterogeneity of unvaccinated dogs, especially stray dogs; and, 3) Suboptimal placement of vaccine tents across the urban landscape. Under a first aim, a qualitative study and a survey are proposed to identify social and spatial determinants of canine vaccination uptake in urban settings. The second aim will evaluate mathematically different strategies that consider the role of stray dogs in rabies control programs. Finally, the third aim will incorporate social and spatial factors into a mathematical algorithm to optimize the location of vaccine tents. For this third study, a discrete-choice experiment will be performed to test the acceptability of the optimized vaccine stand placements. This proposal aims to produce an urgently needed novel approach for zoonotic disease control programs in cities to integrate urban landscapes, health behaviors, diverse populations, and optimal placement of health service facilities.

项目总结

项目成果

Do Incentives Crowd Out Motivation? A Feasibility Study of a Community Vector-Control Campaign in Peru.

激励措施会排挤动力吗？

• DOI: 10.1080/08964289.2021.1977603
• 发表时间: 2023
• 期刊: Behavioral medicine (Washington, D.C.)
• 作者: Buttenheim,AlisonM;Castillo-Neyra,Ricardo;Arevalo-Nieto,Claudia;Shinnick,JuliannaE;Sheen,JustinK;Volpp,KevinG;Paz-Soldan,Valerie;Behrman,JereR;Levy,MichaelZ
• 通讯作者: Levy,MichaelZ

Socio-Demographic Determinants Associated with Blastocystis Infection in Arequipa, Peru.

• DOI: 10.4269/ajtmh.20-0631
• 发表时间: 2020-11-16
• 期刊: The American journal of tropical medicine and hygiene
• 作者: Salazar-Sánchez RS;Ascuña-Durand K;Ballón-Echegaray J;Vásquez-Huerta V;Martínez-Barrios E;Castillo-Neyra R
• 通讯作者: Castillo-Neyra R

Dog Population Rabies Immunity before a Mass Vaccination Campaign in Lima, Peru: Vulnerabilities for Virus Reestablishment.

• DOI: 10.4269/ajtmh.22-0530
• 发表时间: 2023-08-02
• 期刊: The American journal of tropical medicine and hygiene
• 作者: Chuquista-Alcarraz O;Falcón N;Vigilato MAN;Rocha F;Toledo-Barone G;Amorim-Conselheiro J;Recuenco SE;Castillo-Neyra R
• 通讯作者: Castillo-Neyra R

The Amazonian Tropical Bites Research Initiative, a hope for resolving zoonotic neglected tropical diseases in the One Health era.

• DOI: 10.1093/inthealth/ihac048
• 发表时间: 2023-03-01
• 期刊: INTERNATIONAL HEALTH
• 影响因子: 2.5
• 作者: Taylor, Emma;Gladys Aguilar-Ancori, Elsa;Banyard, Ashley C.;Abel, Isis;Mantini-Briggs, Clara;Briggs, Charles L.;Carrillo, Carolina;Gavidia, Cesar M.;Castillo-Neyra, Ricardo;Parola, Alejandro D.;Villena, Fredy E.;Prada, Joaquin M.;Petersen, Brett W.;Falcon Perez, Nestor;Cabezas Sanchez, Cesar;Sihuincha, Moises;Streicker, Daniel G.;Maguina Vargas, Ciro;Navarro Vela, Ana Maria;Vigilato, Marco A. N.;Fan, Hui Wen;Willoughby, Rodney;Horton, Daniel L.;Recuenco, Sergio E.
• 通讯作者: Recuenco, Sergio E.

Relative Frequency of Blastocystis Subtypes 1, 2, and 3 in Urban and Periurban Human Populations of Arequipa, Peru.

秘鲁阿雷基帕市的城市和城市人口中，胚泡亚型1、2和3的相对频率。

• DOI: 10.3390/tropicalmed5040178
• 发表时间: 2020-11-27
• 期刊: Tropical medicine and infectious disease
• 影响因子: 2.9
• 作者: Ascuña-Durand K;Salazar-Sánchez RS;Castillo-Neyra R;Ballón-Echegaray J
• 通讯作者: Ballón-Echegaray J