Control and Prevention of Zoonotic Epidemics in Cities: A Socio-Spatial Approach

城市人畜共患流行病的控制和预防：社会空间方法

• 批准号: 10629256
• 负责人: Ricardo Castillo Neyra
• 金额: $ 13.08万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-06-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10629256
• 关键词: Affect; Algorithms; Animals; Area; Behavior; Biological Models; Canis familiaris; Cities; Communities; Complex; Data; Disease; Domestic Animals; Ecology; Environment; Epidemic; Failure; Focus Groups; Geography; Health; Health Services; Health behavior; Heterogeneity; Human; Individual; Interview; Latin America; Location; Logistic Regressions; Mass Vaccinations; Mathematics; Measures; Methodology; Methods; Modeling; Movement; Peru; Population; Population Density; Population Dynamics; Population Heterogeneity; Prevention; Public Health; RNA Interference; Rabies; Rabies Vaccines; Rabies virus; Research; Risk Reduction; Role; Rural; Rural Community; Seasonal Variations; Statistical Models; Surveys; Testing; United States Public Health Service; Urban Population; Urbanization; Vaccinated; Vaccination; Vaccines; Variant; Work; Zoonoses; community-level factor; design; disorder control; epidemic response; experience; experimental study; feasibility testing; health service use; improved; infection risk; innovation; interdisciplinary approach; mathematical algorithm; mathematical model; member; migration; multidisciplinary; novel strategies; pathogen; prevent; programs; social; social determinants; social factors; transmission process; unvaccinated; uptake; urban area; urban setting; vaccine acceptance; viral transmission

Project Summary Zoonotic diseases present unique challenges for public health due to the complex interactions between humans, animals, pathogens, and the environment. Urbanization, migration, and the urban landscape add additional layers of complexity to these interactions, and the control and prevention of zoonotic pathogens requires innovative multidisciplinary methodological approaches that take into account social, spatial and population dynamics in urban areas. Epidemics of zoonotic pathogens are ongoing in major urban centers across Latin America and worldwide, and among them, the city of Arequipa, Peru is in the midst of a canine rabies epidemic. The drivers of this epidemic work at many levels: Individual- and community-level factors, including social determinants, may explain the currently low vaccination rate of domestic animals against rabies. Urban geography can also affect participation in zoonotic disease control programs, facilitating the emergence of canine rabies and complicating its control. Free-roaming owned and stray dogs with their unique ecology and population dynamics could also impact the results of control activities. In this proposal I will develop a new approach for the control and prevention of zoonotic disease in cities that integrates mathematical and social approaches, using rabies as a model zoonotic disease strongly determined by urban dynamics. Following the urban re-emergence after 15 years, the Ministry of Health has failed to quell the rabies epidemic in Arequipa's complex urban environment. I hypothesize that the failure is due primarily to three factors: 1) Poorly understood determinants of canine vaccination uptake; 2) Ignored spatial heterogeneity of unvaccinated dogs, especially stray dogs; and, 3) Suboptimal placement of vaccine tents across the urban landscape. Under a first aim, a qualitative study and a survey are proposed to identify social and spatial determinants of canine vaccination uptake in urban settings. The second aim will evaluate mathematically different strategies that consider the role of stray dogs in rabies control programs. Finally, the third aim will incorporate social and spatial factors into a mathematical algorithm to optimize the location of vaccine tents. For this third study, a discrete-choice experiment will be performed to test the acceptability of the optimized vaccine stand placements. This proposal aims to produce an urgently needed novel approach for zoonotic disease control programs in cities to integrate urban landscapes, health behaviors, diverse populations, and optimal placement of health service facilities.

项目摘要 人畜共患病对公共卫生提出了独特的挑战，这是由于以下因素之间的复杂相互作用： 人类、动物、病原体和环境。城市化、移民和城市景观 这些相互作用的复杂性以及人畜共患病病原体的控制和预防 需要创新的多学科方法，考虑到社会、空间和 城市人口动态。 人畜共患病病原体的流行正在拉丁美洲的主要城市中心持续， 其中，秘鲁的阿雷基帕市正处于犬狂犬病流行之中。司机 个人和社区一级的因素，包括社会决定因素， 可以解释目前家畜狂犬病疫苗接种率低的原因。城市地理学也可以 影响参与人畜共患病控制计划，促进犬狂犬病的出现， 使其控制复杂化。自由漫游的自有和流浪狗及其独特的生态和人口 动态也可能影响控制活动的结果。在本提案中，我将开发一种新的方法， 在城市中控制和预防人畜共患病，将数学和社会方法相结合， 使用狂犬病作为一种由城市动态强烈决定的人畜共患疾病的模型。 继15年后城市再次出现狂犬病后，卫生部未能平息狂犬病 在阿雷基帕复杂的城市环境中流行。我假设失败主要是由于三个原因 因素：1）对犬接种疫苗吸收的决定因素了解不多; 2）忽略了 未接种疫苗的狗，特别是流浪狗;以及，3）整个城市的疫苗帐篷放置不佳 景观 在第一个目标下，提出了一个定性研究和调查，以确定社会和空间 城市环境中犬疫苗接种率的决定因素。第二个目标将从数学上评估 不同的策略，考虑到流浪狗在狂犬病控制计划中的作用。最后，第三个目标将 将社会和空间因素纳入数学算法，以优化疫苗帐篷的位置。 对于这第三项研究，将进行离散选择实验，以测试优化的 疫苗摊位。 该提案旨在为中国的人畜共患病控制项目提供一种迫切需要的新方法。 城市整合城市景观，健康行为，多样化的人口，以及健康的最佳安置 服务设施。

项目成果

Do Incentives Crowd Out Motivation? A Feasibility Study of a Community Vector-Control Campaign in Peru.

激励措施会排挤动力吗？

• DOI: 10.1080/08964289.2021.1977603
• 发表时间: 2023
• 期刊: Behavioral medicine (Washington, D.C.)
• 作者: Buttenheim,AlisonM;Castillo-Neyra,Ricardo;Arevalo-Nieto,Claudia;Shinnick,JuliannaE;Sheen,JustinK;Volpp,KevinG;Paz-Soldan,Valerie;Behrman,JereR;Levy,MichaelZ
• 通讯作者: Levy,MichaelZ

Socio-Demographic Determinants Associated with Blastocystis Infection in Arequipa, Peru.

• DOI: 10.4269/ajtmh.20-0631
• 发表时间: 2020-11-16
• 期刊: The American journal of tropical medicine and hygiene
• 作者: Salazar-Sánchez RS;Ascuña-Durand K;Ballón-Echegaray J;Vásquez-Huerta V;Martínez-Barrios E;Castillo-Neyra R
• 通讯作者: Castillo-Neyra R

Dog Population Rabies Immunity before a Mass Vaccination Campaign in Lima, Peru: Vulnerabilities for Virus Reestablishment.

• DOI: 10.4269/ajtmh.22-0530
• 发表时间: 2023-08-02
• 期刊: The American journal of tropical medicine and hygiene
• 作者: Chuquista-Alcarraz O;Falcón N;Vigilato MAN;Rocha F;Toledo-Barone G;Amorim-Conselheiro J;Recuenco SE;Castillo-Neyra R
• 通讯作者: Castillo-Neyra R

The Amazonian Tropical Bites Research Initiative, a hope for resolving zoonotic neglected tropical diseases in the One Health era.

• DOI: 10.1093/inthealth/ihac048
• 发表时间: 2023-03-01
• 期刊: INTERNATIONAL HEALTH
• 影响因子: 2.5
• 作者: Taylor, Emma;Gladys Aguilar-Ancori, Elsa;Banyard, Ashley C.;Abel, Isis;Mantini-Briggs, Clara;Briggs, Charles L.;Carrillo, Carolina;Gavidia, Cesar M.;Castillo-Neyra, Ricardo;Parola, Alejandro D.;Villena, Fredy E.;Prada, Joaquin M.;Petersen, Brett W.;Falcon Perez, Nestor;Cabezas Sanchez, Cesar;Sihuincha, Moises;Streicker, Daniel G.;Maguina Vargas, Ciro;Navarro Vela, Ana Maria;Vigilato, Marco A. N.;Fan, Hui Wen;Willoughby, Rodney;Horton, Daniel L.;Recuenco, Sergio E.
• 通讯作者: Recuenco, Sergio E.

Relative Frequency of Blastocystis Subtypes 1, 2, and 3 in Urban and Periurban Human Populations of Arequipa, Peru.

秘鲁阿雷基帕市的城市和城市人口中，胚泡亚型1、2和3的相对频率。

• DOI: 10.3390/tropicalmed5040178
• 发表时间: 2020-11-27
• 期刊: Tropical medicine and infectious disease
• 影响因子: 2.9
• 作者: Ascuña-Durand K;Salazar-Sánchez RS;Castillo-Neyra R;Ballón-Echegaray J
• 通讯作者: Ballón-Echegaray J