The Study of Muscle and Physical Performance in African Caribbeans

非洲加勒比海地区肌肉和身体表现的研究

• 批准号: 10669932
• 负责人: Adam J Santanasto
• 金额: $ 5.6万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10669932
• 关键词: African Caribbean; Body Composition; Body measure procedure; Clinic; Data; FDA approved; Fatty acid glycerol esters; Funding; Gold; Health; Image; Measures; Medical; Methods; Muscle; Parents; Physical Function; Physical Performance; Population; Process; Roentgen Rays; Skeletal Muscle; System; Thinness; Time; Tobago; Visit; muscle form; parent grant; repaired; sarcopenia; standard measure

Project Summary/Abstract: Supplemental funding is requesting to purchase a preowned Hologic Horizon Dual X-ray Absorptiometry (DXA) Machine for the Tobago Health Studies (THS) Clinic. We have collected serial DXA images to measure body composition in the THS for 20 years (4 visits), and the Hologic 4500W DXA machine we have malfunctioned during the review process of the parent grant (R01AG074956) and is no longer in working order. The machine was manufactured in 2000 and has been discontinued by Hologic and the parts required to repair the machine are no longer available. The QDR 4500W is an FDA approved system and must be calibrated to factory standards and validated by a medical physicist – which is not possible. We did not budget for this in R01AG074956, as the machine was in good working order at the time of submission and during most of the review period. The primary purpose of DXA for this proposal was to measure total body and appendicular fat mass and using DXA as originally proposed has several advantages over less expensive methods of fat mass. First, switching to BIA will mean the end of the serial DXA measures that have been ongoing since 2000, and used to calculate invaluable longitudinal change data. Second, despite recent scrutiny, DXA is still considered a “gold standard” for measuring lean and fat mass and is included in just about all definitions of “sarcopenia”. For this reason, DXA has been and is being used by many studies to segment lean and fat mass. Thus, the continued use of DXA would provide the invaluable opportunity for direct comparisons with other populations. Third, DXA is more accurate than BIA for measuring fat mass and has been used to evaluate BIA's accuracy. Finally, the primary measure of total body skeletal muscle mass in this study is D3Cr, and while this method has shown to have stronger relationships with physical function in the MrOS study, these comparisons have not been made in other populations. Thus, the inclusion of DXA, as originally proposed, would significantly enhance the aims and scientific contributions of the parent R01.

项目摘要/摘要： 补充资金要求购买预先拥有的Holotic Horizo​​n双X射线吸收仪（DXA） 多巴哥健康研究（THS）诊所的机器。我们收集了串行DXA图像以测量身体 THS组成20年（4次访问）和HOTHOLIC 4500W DXA机器，我们发生了故障 在父母赠款（R01AG074956）的审查过程中，不再处于工作状态。机器 于2000年制造，已被Hologic和修复机器所需的零件停止 不再可用。 QDR 4500W是FDA批准的系统，必须校准工厂 标准并由医学物理学家验证 - 这是不可能的。我们没有为此预算 R01AG074956，因为在提交时和大多数情况下，机器处于良好的工作状态 审查期。该提案的DXA的主要目的是测量全身和阑尾脂肪 质量和最初提出的DXA使用比较便宜的脂肪质量方法具有多个优点。 首先，切换到BIA将意味着自2000年以来一直在进行的串行DXA测量的结束，并且 用于计算宝贵的纵向变化数据。其次，目的地最近的审查仍在考虑DXA 用于测量瘦肉和脂肪质量的“黄金标准”，几乎包括在“肌肉减少症”的所有定义中。 因此，DXA已经过去了，许多研究已将其用于细分瘦肉和脂肪质量。那， 继续使用DXA将为与其他人群的直接比较提供无价的机会。 第三，用于测量脂肪质量的DXA比BIA更准确，并且已用于评估BIA的准确性。 最后，这项研究中总体骨骼肌质量的主要度量是D3CR，而这种方法 在MROS研究中，已经证明与身体机能具有更强的关系，这些比较具有 没有在其他人群中进行。这是最初提出的DXA的包含，将显着 增强父r01的目标和科学贡献。