The Study of Muscle and Physical Performance in African Caribbeans

非洲加勒比海地区肌肉和身体表现的研究

• 批准号: 10669932
• 负责人: Adam J Santanasto
• 金额: $ 5.6万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10669932
• 关键词: African Caribbean; Body Composition; Body measure procedure; Clinic; Data; FDA approved; Fatty acid glycerol esters; Funding; Gold; Health; Image; Measures; Medical; Methods; Muscle; Parents; Physical Function; Physical Performance; Population; Process; Roentgen Rays; Skeletal Muscle; System; Thinness; Time; Tobago; Visit; muscle form; parent grant; repaired; sarcopenia; standard measure

Project Summary/Abstract: Supplemental funding is requesting to purchase a preowned Hologic Horizon Dual X-ray Absorptiometry (DXA) Machine for the Tobago Health Studies (THS) Clinic. We have collected serial DXA images to measure body composition in the THS for 20 years (4 visits), and the Hologic 4500W DXA machine we have malfunctioned during the review process of the parent grant (R01AG074956) and is no longer in working order. The machine was manufactured in 2000 and has been discontinued by Hologic and the parts required to repair the machine are no longer available. The QDR 4500W is an FDA approved system and must be calibrated to factory standards and validated by a medical physicist – which is not possible. We did not budget for this in R01AG074956, as the machine was in good working order at the time of submission and during most of the review period. The primary purpose of DXA for this proposal was to measure total body and appendicular fat mass and using DXA as originally proposed has several advantages over less expensive methods of fat mass. First, switching to BIA will mean the end of the serial DXA measures that have been ongoing since 2000, and used to calculate invaluable longitudinal change data. Second, despite recent scrutiny, DXA is still considered a “gold standard” for measuring lean and fat mass and is included in just about all definitions of “sarcopenia”. For this reason, DXA has been and is being used by many studies to segment lean and fat mass. Thus, the continued use of DXA would provide the invaluable opportunity for direct comparisons with other populations. Third, DXA is more accurate than BIA for measuring fat mass and has been used to evaluate BIA's accuracy. Finally, the primary measure of total body skeletal muscle mass in this study is D3Cr, and while this method has shown to have stronger relationships with physical function in the MrOS study, these comparisons have not been made in other populations. Thus, the inclusion of DXA, as originally proposed, would significantly enhance the aims and scientific contributions of the parent R01.

项目概要/摘要： 补充资金正在申请购买二手Hologic Horizon Dual X射线吸收测定仪（DXA） 托巴哥健康研究（THS）诊所的机器。我们收集了一系列DXA图像来测量身体 组成在THS的20年（4次访问），和Hologic 4500 W DXA机器，我们已经发生故障 在母基金（R 01 AG 074956）的审查过程中，不再处于工作状态。机器 2000年生产，Hologic已停产，维修机器所需的零件 已经没有了QDR 4500 W是FDA批准的系统，必须在出厂时进行校准 标准，并由医学物理学家验证-这是不可能的。我们没有为这个做预算， R 01 AG 074956，因为机器在提交时和大部分 审查期间。DXA的主要目的是测量全身和脂肪 质量和使用DXA作为最初提出的有几个优点，比较便宜的方法的脂肪质量。 首先，切换到BIA将意味着自2000年以来一直在进行的系列DXA措施的结束， 用于计算宝贵的纵向变化数据。其次，尽管最近的审查，DXA仍然被认为是 测量瘦体重和脂肪量的“黄金标准”，并且包括在几乎所有“肌肉减少症”的定义中。 出于这个原因，DXA已经并正在被许多研究用于分割瘦体重和脂肪量。因此 继续使用DXA将为与其他人群进行直接比较提供宝贵的机会。 第三，DXA比BIA更准确地测量脂肪量，并已被用于评估BIA的准确性。 最后，本研究中全身骨骼肌质量的主要指标是D3 Cr，而这种方法 在MrOS研究中显示与身体功能有更强的关系，这些比较 在其他人群中是没有的。因此，如最初提议的那样，将DXA纳入其中， 增强R 01母体的目标和科学贡献。