Training in Molecular Epidemiology: Linking Genes to Physical Function in Older Adults
分子流行病学培训:将基因与老年人的身体功能联系起来
基本信息
- 批准号:9751693
- 负责人:
- 金额:$ 11.65万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-08-01 至 2023-04-30
- 项目状态:已结题
- 来源:
- 关键词:AddressAdoptedAerobicAged, 80 and overAgingAnimalsAreaAwardBioinformaticsBiologicalBiological AssayBiological MarkersBiological ProcessBiology of AgingBiometryBloodBody Weight decreasedCell Culture TechniquesCellsClinicalCohort AnalysisConsultationsDNADataElderlyEnzyme-Linked Immunosorbent AssayEpidemiologic MethodsEpidemiologistEpidemiologyEquilibriumExpression ProfilingFamilyFamily StudyFibrosisFoundationsFunctional disorderFundingGene ProteinsGenesGeneticGenetic PolymorphismGenetic TranscriptionGenomic SegmentGeroscienceHealth Care CostsHealthcareHeartHeart failureHumanHuman GeneticsImpairmentInstitutionalizationInterventionInvestmentsK-Series Research Career ProgramsKnowledgeLeadLifeLife StyleLinkLiver diseasesLongevityMapsMeasuresMentorsMentorshipMessenger RNAMeta-AnalysisMethodsMitochondriaMolecularMolecular BiologyMolecular EpidemiologyMulticenter StudiesMuscleMyocardialN-terminalNatural regenerationPathogenicityPathway interactionsPhenotypePhysical FunctionPhysical activityPlasmaPlasma ProteinsPopulationPositioning AttributePostdoctoral FellowProcollagenProteinsPublic HealthRNAResearchResearch PersonnelResearch TrainingRoleSamplingSerumSeverity of illnessSignal TransductionSignaling ProteinSkeletal MuscleTGF Beta Signaling PathwayTestingTissuesTrainingTransducersTransforming Growth Factor betaUnited States National Institutes of HealthWalkingage relatedage-related muscle lossbasebiomarker developmentcareercohortdensitydesigndisabilityepidemiology studyfollow-upfunctional declinegenetic epidemiologygenetic linkage analysisgenetic variantgenome wide association studygenome-widegenome-wide linkagegenomic epidemiologyhigh riskimprovedinnovationinsightintervention effectlifestyle interventionmRNA Expressionmortalitymuscle agingnovelpotential biomarkerprematurepreventprotein biomarkersskeletal muscle differentiationskillsstatisticsstrength trainingtherapeutic target
项目摘要
Age-related declines in physical function are common and lead to increased health care costs, institutionalization and
mortality. As a traditional epidemiologist with unique expertise in skeletal muscle aging and physical function, I have
researched lifestyle interventions (weight loss, aerobic and resistance training) to prevent age-related declines in physical
function. However, lifestyle changes are difficult to adopt, especially for those at the highest risk for functional decline. To
extend the benefits of these interventions, it is imperative to understand biological processes underlying changes in function
with aging and following intervention. As such, the current proposal will provide the candidate with advanced training in
molecular epidemiology and biology of aging, yield novel insight on the genetic and biological basis of physical function
among older adults and lay the foundation for future research. Specially, Aim 1 will identify genes and genetic variants for
physical function and changes in physical function with aging. Aim 2 will examine blood RNA expression for components
of the transforming growth factor beta (TGF-β) pathway, which is implicated in muscle dysfunction and pathogenic fibrosis,
with physical function and its change with aging. Aim 3 will test if serum levels of TGF-β and procollagen type 3 N-
terminal propeptide (P3NP - a biomarker of pathogenic fibrosis) are related physical function among older adults. I will
leverage robustly collected physical function measures, biological samples, and an ultra-high-density genome-wide
polymorphism map from the NIA-funded Long Life Family Study (LLFS), a multi-center study of exceptional aging and
longevity in families and from
The Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE)
Consortium
. The proposed research and training is very innovative. First, despite being implicated in several age-related
conditions there have been no human studies that have examined the relationship between TGF-β or P3NP and physical
function. Further, LLFS has a large number of “oldest old”, who are understudied and at the highest risk for functional
decline. There has also been limited research on the genetics of physical function. The proposed career development award
will provide the applicant with essential new mentorship, knowledge and skills in human genetics and molecular
epidemiology including but not limited to blood RNA expression and protein biomarker development (Aim 2 and 3),
genome wide association (GWA) and linkage analyses (Aim 1
), meta-analysis
(Aim 1) and bioinformatics (Aim 1)
approaches to follow-up association and linkage analyses. Finally, this award will be critical for facilitating my transition
to an independent research career in aging and molecular epidemiology with a focus on physical function. As an
epidemiologist with expertise in both traditional and molecular methods,
I will be well-positioned to contribute to the
advancement of the evolving field of GeroScience.
与年龄相关的身体机能下降是常见的,并导致医疗费用增加,制度化和
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Adam J Santanasto其他文献
THE PITTSBURGH FATIGABILITY SCALE: VALIDATION OF THE MENTAL SUBSCALE IN THE LONG LIFE FAMILY STUDY
匹兹堡疲劳量表:长寿家庭研究中心理量表的验证
- DOI:
- 发表时间:
2019 - 期刊:
- 影响因子:7
- 作者:
Sharon W Renner;Patrick J. Brown;T. Bear;S. Andersen;Stephanie Cosentino;R. Boudreau;Adam J Santanasto;N. Glynn - 通讯作者:
N. Glynn
Adam J Santanasto的其他文献
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{{ truncateString('Adam J Santanasto', 18)}}的其他基金
The Study of Muscle and Physical Performance in African Caribbeans
非洲加勒比海地区肌肉和身体表现的研究
- 批准号:
10669932 - 财政年份:2022
- 资助金额:
$ 11.65万 - 项目类别:
The Study of Muscle and Physical Performance in African Caribbeans.
非洲加勒比海地区肌肉和身体表现的研究。
- 批准号:
10337382 - 财政年份:2022
- 资助金额:
$ 11.65万 - 项目类别:
Training in Molecular Epidemiology: Linking Genes to Physical Function in Older Adults
分子流行病学培训:将基因与老年人的身体功能联系起来
- 批准号:
10393493 - 财政年份:2018
- 资助金额:
$ 11.65万 - 项目类别:
Training in Molecular Epidemiology: Linking Genes to Physical Function in Older Adults
分子流行病学培训:将基因与老年人的身体功能联系起来
- 批准号:
9908039 - 财政年份:2018
- 资助金额:
$ 11.65万 - 项目类别:
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