Development of the INI-4001 and INI-2002 adjuvants within the context of a vaccine to prevent Lyme disease.

在预防莱姆病的疫苗范围内开发 INI-4001 和 INI-2002 佐剂。

• 批准号: 10667372
• 负责人: JAY EVANS
• 金额: $ 100万
• 依托单位: UNIVERSITY OF MONTANA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-30 至 2024-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10667372
• 关键词: Adjuvant; Affect; Agonist; American; Bacteriophages; Bite; Borrelia burgdorferi; Capsid Proteins; Chronic; Contractor; Development; Formulation; Health; Human; Ixodes; Lipoproteins; Lyme Arthritis; Lyme Disease; Lyme Disease Encephalopathy; Lyme Disease Vaccines; Modeling; Mus; Route; TLR4 gene; TLR7 gene; Ticks; Vaccination; Vaccine Adjuvant; Vaccine Antigen; Vaccines; Virion; efficacy study; immunogenicity; novel; prevent; skin disorder; transmission process

Lyme disease, caused by the bite of Borrelia burgdorferi-infect Ixodes ticks, affects close to half a million Americans each year and can cause serious, long term, chronic health issues such as Lyme arthritis, Lyme encephalopathy, or skin disorders. No human vaccine is currently available and the contractor proposes to develop a novel subunit Lyme disease vaccine adjuvanted with a combination adjuvant composed of two synthetic TLR agonists (TLR4 and TLR7/8).

莱姆病是由Borrelia burgdorferi-Infect Ixodes tick的咬伤引起的，每年影响近半百万的美国人，可能会引起严重的，长期的，慢性健康问题，例如莱姆关节炎，莱姆氏症，莱姆脑病或皮肤疾病。目前尚无人疫苗，承包商建议开发一种新型亚基莱姆病疫苗，该疫苗佐剂与由两种合成TLR激动剂组成的组合佐剂（TLR4和TLR7/8）组成。