Development of the INI-4001 and INI-2002 adjuvants within the context of a vaccine to prevent Lyme disease.
Development of the INI-4001 and INI-2002 adjuvants within the context of a vaccine to prevent Lyme disease.
批准号:
10667372
负责人:
JAY EVANS
金额:
$100.0万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2018
资助国家:
美国
项目状态:
已结题
起止时间:
2018-09-30 至 2024-09-29
关键词:
AdjuvantAffectAgonistAmericanBacteriophagesBiteBorrelia burgdorferiCapsid ProteinsChronicContractorDevelopmentFormulationHealthHumanIxodesLipoproteinsLyme ArthritisLyme DiseaseLyme Disease EncephalopathyLyme Disease VaccinesModelingMusRouteTLR4 geneTLR7 geneTicksVaccinationVaccine AdjuvantVaccine AntigenVaccinesVirionefficacy studyimmunogenicitynovelpreventskin disordertransmission process
中文摘要
点击翻译按钮获取中文摘要
英文摘要
Lyme disease, caused by the bite of Borrelia burgdorferi-infect Ixodes ticks, affects close to half a million Americans each year and can cause serious, long term, chronic health issues such as Lyme arthritis, Lyme encephalopathy, or skin disorders. No human vaccine is currently available and the contractor proposes to develop a novel subunit Lyme disease vaccine adjuvanted with a combination adjuvant composed of two synthetic TLR agonists (TLR4 and TLR7/8).
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
DEVELOPMENT OF UM-1098: A NOVEL SYNTHETIC TH17 INDUCING ADJUVANT AND DELIVERY SYSTEM
-
批准号:10935819
-
项目类别:
-
资助金额:$241.99万
-
财政年份:2023
-
负责人:JAY EVANS
-
依托单位:
Discovery of novel synthetic IL-1 adjuvants
-
批准号:10838414
-
项目类别:
-
资助金额:$222.31万
-
财政年份:2021
-
负责人:JAY EVANS
-
依托单位:
Development of an Optimized Adjuvanted TB Vaccine
-
批准号:10681631
-
项目类别:
-
资助金额:$207.62万
-
财政年份:2021
-
负责人:JAY EVANS
-
依托单位:
Characterize and optimize adjuvants to test monkeypox vaccines
-
批准号:10610275
-
项目类别:
-
资助金额:$159.9万
-
财政年份:2021
-
负责人:JAY EVANS
-
依托单位:
Discovery of novel synthetic IL-1 adjuvants
-
批准号:10610274
-
项目类别:
-
资助金额:$261.3万
-
财政年份:2021
-
负责人:JAY EVANS
-
依托单位:
Discovery of novel synthetic IL-1 adjuvants
-
批准号:10027052
-
项目类别:
-
资助金额:$142.57万
-
财政年份:2019
-
负责人:JAY EVANS
-
依托单位:
Discovery of novel synthetic IL-1 adjuvants
-
批准号:10454737
-
项目类别:
-
资助金额:$252.17万
-
财政年份:2019
-
负责人:JAY EVANS
-
依托单位:
COVID - Spplement VACCINE ADJ DISCOVERY PROGRAM (VADP)
-
批准号:10301500
-
项目类别:
-
资助金额:$369.97万
-
财政年份:2019
-
负责人:JAY EVANS
-
依托单位:
Adjuvant development in the context of seasonal and pandemic influenza
-
批准号:10455393
-
项目类别:
-
资助金额:$358.38万
-
财政年份:2018
-
负责人:JAY EVANS
-
依托单位:
Adjuvant development in the context of seasonal and pandemic influenza
-
批准号:10249933
-
项目类别:
-
资助金额:$397.13万
-
财政年份:2018
-
负责人:JAY EVANS
-
依托单位:
Identification of novel Th17 inducing CTLR agonists for vaccines against mycobacterium tuberculosis
-
批准号:8936738
-
项目类别:
-
资助金额:$508.21万
-
财政年份:2014
-
负责人:JAY EVANS
-
依托单位:
Identification of novel Th17 inducing CTLR agonists for vaccines against mycobacterium tuberculosis
-
批准号:10018599
-
项目类别:
-
资助金额:$84.72万
-
财政年份:2014
-
负责人:JAY EVANS
-
依托单位:
海外基金