Characterizing the spatial distribution of color vision deficiencies in diabetes and prediabetes

描述糖尿病和糖尿病前期色觉缺陷的空间分布特征

• 批准号: 10667262
• 负责人: Daniel Robert COATES
• 金额: $ 23.25万
• 依托单位: UNIVERSITY OF HOUSTON
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10667262
• 关键词: Address; Adult; Affect; Aftercare; Age; American; Anatomy; Area; Awareness; Biological Markers; Blindness; Blood Glucose; Blood Pressure; Blood Vessels; Body Size; Body fat; Calibration; Cells; Cholesterol; Clinical; Color; Color Perception; Color Visions; Cone; Custom; Data; Development; Diabetes Mellitus; Diabetic Retinopathy; Diagnosis; Discrimination; Disease; Disease Management; Disease Progression; Early Diagnosis; Edema; Electroretinography; Epidemic; Evaluation; Eye; Eye diseases; Foundations; Fundus photography; Future; Glaucoma; Glycosylated hemoglobin A; Goals; Health; Impairment; Knowledge; Learning; Location; Longitudinal Studies; Measures; Methods; Nature; Neurons; Non-Insulin-Dependent Diabetes Mellitus; Pathology; Pathway interactions; Patients; Perimetry; Prediabetes syndrome; Process; Public Health; Radial; Recovery; Research; Retina; Retinal Diseases; Spatial Distribution; Spottings; System; Techniques; Testing; Thinness; Time; Treatment outcome; Variant; Vision; Vision Tests; Visual Fields; Visual Pathways; Work; aged; central visual field; cohort; color category; color processing; diabetic; falls; fovea centralis; fundus imaging; glycemic control; illness length; improved; koniocellular; macular edema; novel; outcome prediction; parvocellular; tomography

Type 2 Diabetes is a leading cause of blindness in working-aged Americans. Vision loss comes from diabetic eye disease which includes diabetic retinopathy and edema. Diabetic eye disease can appear at any retinal location and damages both the inner and outer retina. There are no treatments outside of glycemic control for early diabetic eye disease. Methods for early diagnosis and detection, especially if location-specific, are important as they can help doctors and patients to be proactive in delaying retinopathy and vision loss. Current clinical tests such as multifocal electroretinograms (mfERG), ocular coherence tomography (OCT), and color vision assessment have been widely shown to be altered in early diabetes. However, there has been little work to characterize localized color vision deficiencies across the diabetic retina, and it remains unclear exactly which cells are implicated in color vision losses. To address these gaps, the proposed research will test patients using a custom chromatic microperimeter to precisely quantify color discrimination across the visual field. In Aim 1, color thresholds from patients with diabetes and prediabetes will be shown to differ from normally sighted control subjects, with the degree of impairment and variation in testing correlated with HbA1c levels. In addition to expected reductions in the blue-yellow pathway, it is hypothesized that the red-green pathway will show a deficiency as well, addressing the controversy concerning whether S-cone loss alone underlies the color vision deficits in diabetes. In Aim 2, additional co-registered structural and functional measures from mfERG, OCT, and fundus photography will reveal that spatially localized losses are associated with regions of damage, laying the foundation for future longitudinal studies aimed at the early detection of affected regions in diabetes and prediabetes. The ability to predict which areas are most affected could constitute a significant advance in diagnosis and management of this disease and potentially create new end points for future studies and trials. Diabetes has reached epidemic proportions in the US and worldwide and better understanding the effects of the disease could lead to improvements in the lives of these patients.

2型糖尿病是导致美国工作年龄人群失明的主要原因。失明是由糖尿病引起的