Electroencephalographic signatures of dysfunctional cerebrovascular autoregulation as biomarkers of brain injury in aneurysmal subarachnoid hemorrhage (SAH)

脑血管自动调节功能障碍的脑电图特征作为动脉瘤性蛛网膜下腔出血（SAH）脑损伤的生物标志物

• 批准号: 10667162
• 负责人: Jennifer A Kim
• 金额: $ 25.13万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-15 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10667162
• 关键词: Acute; Adult; Affect; Aneurysmal Subarachnoid Hemorrhages; Benchmarking; Biological Markers; Blood Pressure; Blood Vessels; Brain; Brain Injuries; Brain hemorrhage; Caring; Cerebral Ischemia; Cerebral hemisphere hemorrhage; Cerebral perfusion pressure; Cerebrovascular Circulation; Cerebrovascular Disorders; Cerebrovascular Spasm; Cerebrum; Clinical; Clinical Trials; Cohort Studies; Compensation; Complication; Coupled; Critical Illness; Data; Detection; Deterioration; Development; Disabled Persons; Disease; Distress; Early Diagnosis; Early Intervention; Electroencephalography; Exogenous Factors; Failure; Fright; Functional disorder; Future; Goals; Hemorrhage; Homeostasis; Individual; Informatics; Infrastructure; Intervention; Intracranial Pressure; Ischemia; Ischemic Stroke; Knowledge; Link; Metabolic; Metabolism; Mission; Modeling; Monitor; Morbidity - disease rate; Nature; Near-Infrared Spectroscopy; Nervous System Trauma; Neurologic; Neurologic Deficit; Neurology; Neurons; Operative Surgical Procedures; Outcome; Patients; Pattern; Perfusion; Phase; Phenotype; Physiological; Physiology; Play; Principal Investigator; Protocols documentation; Quality of life; Recovery; Research; Research Proposals; Resources; Rest; Risk; Risk Assessment; Ruptured Aneurysm; Sedation procedure; Signal Transduction; Stroke; Subarachnoid Hemorrhage; Subarachnoid Space; Survivors; Technology; Testing; Therapeutic; Time; Transcranial Doppler Ultrasonography; United States; United States National Institutes of Health; Vasospasm; biomarker driven; blood pressure control; cerebral hemodynamics; cerebral hypoperfusion; cerebrovascular; clinical center; clinical investigation; clinical practice; cohort; data repository; diagnostic strategy; disability; epileptiform; exhaust; functional improvement; functional outcomes; high risk; hypoperfusion; improved; individual patient; innovation; insight; nervous system disorder; neurophysiology; neuroprotection; neurovascular; novel; personalized approach; personalized medicine; pharmacologic; population based; precision medicine; pressure; prevent; prospective; risk mitigation; signal processing; tissue oxygenation; tool; treatment strategy

Abstract Aneurysmal subarachnoid hemorrhage (aSAH) remains a devastating disease affecting approximately 30,000 adults in the United States per year. Forty percent of aSAH patients die within 30 days, and over one-third of survivors sustain major neurologic deficits, in part due to feared secondary complications like vasospasm and delayed cerebral ischemia (DCI). Despite advances in care, few interventions can mitigate the risk of neurologic worsening after the initial bleed, and current monitoring strategies to identify impending DCI have limited accuracy. Abnormalities in cerebrovascular autoregulation and flow-metabolism uncoupling in the acute phase after aSAH have been shown to increase the risk of secondary brain injury and likely represent key players in the development of DCI. In this proposal, we plan to develop and refine an innovative, personalized approach to blood pressure management to identify patients most likely to benefit from therapeutic BP manipulation. To carry out this overarching aim, we will track continuous recordings of intracranial pressure, near-infrared spectroscopy, and EEG to determine patient-specific blood pressure targets that yield optimal brain blood flow and metabolism. This research proposal will evaluate if cerebral hemodynamic dysregulation drives EEG deterioration (Aim 1) and if a deviation from optimized blood pressure targets is associated with DCI and poor outcomes (Aim 2). We will then prospectively validate our results in a pilot cohort study. This proposal’s feasibility rests on (1) several years of research conducted by the principal investigators on signal processing, autoregulatory physiology, and continuous EEG in disease states like SAH and ischemic stroke, and (2) promising preliminary analyses evaluating the hypotheses being explored in this proposal. In total, this autoregulation-oriented neuroprotective therapy aims to optimize cerebral perfusion and ultimately improve clinical and functional outcomes. This research proposal is thus directly aligned with the NIH mission to reduce the burden of neurological disorders and enhance the quality of life of people with disabilities. The study will leverage Yale’s cutting-edge neuro- monitoring technologies along with extensive informatics and research resources of the Yale Center for Clinical Investigation to generate new insights into cerebral hemodynamics after aSAH and identify treatment opportunities. This line of research is readily translatable to the bedside and also applies to other cerebrovascular diseases like intracerebral hemorrhage and ischemic stroke, both of which likely encompass dysautoregulation as a critical physiologic variable. Knowledge gained in this study is anticipated to lead to a significant shift in the treatment approach for aSAH patients. It may ultimately lead to a clinical trial testing autoregulation-based treatment strategies, including tailored pharmacologic BP modulation based on patients’ real-time autoregulatory status. Our long-term goal is to use neuro-monitoring to develop physiology-based, personalized, early interventions to reduce the disability and morbidity associated with neurologic injury.

摘要