动物核心设施-猫眼课题宝

动物核心设施

批准号：

10666695

负责人：

John Curlee Wilkinson

金额：

$59.72万

依托单位：

NORTH DAKOTA STATE UNIVERSITY

依托单位国家：

美国

项目类别：

财政年份：

2016

资助国家：

美国

项目状态：

未结题

起止时间：

2016-03-01 至 2027-06-30

来源：

https://reporter.nih.gov/project-details/10666695

关键词：

Achievement Address Advisory Committees Animal Cancer Model Animal Experimentation Animal Experiments Animal Housing Animal Model Animals Apoptosis Area Biological Models Biomedical Research Breeding Cancer Etiology Carcinogenesis Mechanism Cell Communication Centers of Research Excellence Cessation of life Clinical Clinical Management Collaborations Communities Complement Complex Core Facility Development Diagnosis Diagnostic Disease Early Diagnosis Early treatment Elements Ensure Experimental Designs Extramural Activities Faculty Faculty Recruitment Fluorouracil Fostering Genetic Engineering Genetically Engineered Mouse Goals Histocytochemistry Histology Housing IACUC Immunocompromised Host Immunohistochemistry Individual Institution Invaded KPC model KRASG12D Leucovorin Longevity Maintenance Malignant Neoplasms Malignant neoplasm of pancreas Mentors Methods Mission Modeling Mouse Strains Mus National Cancer Institute National Institute of Diabetes and Digestive and Kidney Diseases National Institute of General Medical Sciences Neoplasm Metastasis Pancreatic Ductal Adenocarcinoma Patients Phase Pilot Projects Play Postdoctoral Fellow Productivity Regimen Regulation Research Research Infrastructure Research Personnel Resources Role Sampling Scientist Senior Scientist Services Site Solid Survival Rate Testing Therapeutic Tissues Toxic effect Training United States United States National Institutes of Health animal care anticancer research biobank cancer diagnosis cancer therapy career cell type chemotherapeutic agent efficacy study fluorescence imaging gemcitabine graduate student imaging approach imaging modality implantation improved in vivo irinotecan model development novel novel therapeutic intervention novel therapeutics oxaliplatin patient derived xenograft model programs protocol development standard of care subcutaneous translational study treatment response treatment strategy tumor working group

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Project Summary/Abstract (Animal Core Facility) Animal models play a vital role in the establishment and refinement of improved therapies for various cancers, including pancreatic ductal adenocarcinoma (PDAC). Thus, when the NDSU Center for Diagnostic and Therapeutic Strategies in Pancreatic Cancer was established, a key component included was the Animal Research Core Facility. During Phase I of this project, the Animal Core has made significant contributions to the COBRE project's mission and the overall NDSU research community. A breeding colony of nod-SCID- gamma (NSG™) mice was founded and used in multiple grafting studies, including subcutaneous, orthotopic, and patient-derived xenograft implantations. The Core also established a colony of genetically engineered LSL-KrasG12D/+; LSL-Trp53R172H/+; Pdx-1-Cre (KPC) mice to complement these NSG™ studies. These achievements allowed the Animal Core to complete our original goals of enhancing basic and translational studies devoted to detecting and treating pancreatic cancer and strengthening biomedical research at NDSU. For Phase II, the Animal Core aims are 1) to support the scientific and animal needs of individual Junior Investigators, Pilot Project Investigators, new and existing faculty, postdoctoral fellows, and graduate students associated with the CDTSPC; and 2) to increase the sustainability of the Animal Core Research platform. These aims will be achieved by establishing new colonies of genetically engineered models (including KC- smad4 and KC-Tgfbr2 strains), establishing a tissue biobank for archival maintenance of PDAC and other cancer samples, and expanding services to include on-site histology analysis and advanced imaging modalities.

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Animal Core Facility

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