Training Program in Imaging Sciences in Translational Cardiovascular Research

转化心血管研究成像科学培训项目

• 批准号: 10633063
• 负责人: Flordeliza S Villanueva
• 金额: $ 34.48万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10633063
• 关键词: Cardiovascular system; Image; Research; Science; Training Programs

Advances in imaging technology lead to discoveries in science and medicine. Conversely, pressing questions in science and medicine drive innovation in imaging technology development, underscoring the fundamental symbiosis between imaging and biomedical research. The necessity to connect imaging and biomedical science is particularly salient in cardiovascular research, where imaging the heart and vascular system, from whole organ to molecular levels, figures prominently in the translation of discoveries to bedside diagnosis and treatment. As such, imaging scientists must understand what questions are important in biomedical research, while biomedical scientists must be fluent in the imaging technologies that can facilitate discovery. Our inaugural T32 program (2016)– the first in Cardiology at University of Pittsburgh – was motivated by the recognition that there is a paucity of scientists who can adeptly commute between the imaging science and biomedical research spheres, ultimately compromising the translational relevance of research efforts, and contributing to the “Valley of Death” separating basic discovery and clinical application. To bridge this chasm, our new T32 Program used an innovative educational paradigm to train clinical and basic researchers in a broad spectrum of cutting-edge, multimodality imaging platforms as they pursue hypothesis-driven research, with an emphasis on translational cardiovascular research. While T32s at other institutions focus on traditional cardiovascular imaging tools (e.g., MRI, Echo), our T32 is unique in integrating biological imaging within the biological and physical sciences. Our program was designed such that post-doctoral trainees (MD or PhD) acquire “core competencies” in imaging methods spanning molecular to whole organism (“imaging tool kit”), and translational research methods spanning basic to population levels (“translational tool kit’) – accomplished through a co-mentorship structure, with each trainee having one mentor from imaging sciences and another from the biomedical science arena. Our approach is structured around Individualized Development Plans that have quantifiable milestones, e.g., presentations, publications, grants, didactic courses, or completion of Master’s degrees. Now 4.2 years into our first funding cycle, we seek competitive renewal of our program based on its compelling premise and unmet training need; its occupancy of an important niche in the NHLBI portfolio (only 2% of NHLBI T32s are imaging-focused); the 37 excellent, scientifically diverse, well-funded training faculty; and the successful outcomes of our nascent program thus far. In our 2019 Cardiology Fellowship match for 8 positions (>700 applicants), 4 were filled by MDs committed to our T32 program, highlighting our mandate to train future MD scientists. Dr. Villanueva, a cardiologist, imaging specialist, and researcher with extensive mentoring experience, has ably led our young program alongside 3 seasoned co-Directors and Advisory Boards. Our T32 is enhanced by institutional endowments, research Cores of the Heart, Lung, Blood, and Vascular Medicine Institute, a rich infrastructure from the Clinical Sciences Translational Institute, and interactions with other institutional translational T32s.

成像技术的进步导致科学和医学的发现。相反，紧迫的问题

项目成果

Cardiovascular Hospitalizations and Resource Use Following Atrial Fibrillation Ablation.

• DOI: 10.1161/jaha.122.028609
• 发表时间: 2023-09-19
• 期刊: JOURNAL OF THE AMERICAN HEART ASSOCIATION
• 影响因子: 5.4
• 作者: Dhande, Mehak;Barakat, Amr;Canterbury, Ann;Thoma, Floyd;Mulukutla, Suresh;Sezer, Ahmet;Aronis, Konstantinos N.;Bhonsale, Aditya;Kancharla, Krishna;Voigt, Andrew H.;Wang, Norman C.;Shalaby, Alaa;Mark Estes, N. A., III;Saba, Samir;Jain, Sandeep K.
• 通讯作者: Jain, Sandeep K.

White Coat Hypertension in Pregnancy: The Challenge of Combining Inconsistent Data.

妊娠期白大衣高血压：合并不一致数据的挑战。

• DOI: 10.1161/hypertensionaha.120.15056
• 发表时间: 2020
• 期刊: Hypertension (Dallas, Tex. : 1979)
• 作者: Roberts,JamesM;Countouris,Malamo
• 通讯作者: Countouris,Malamo

Smooth muscle cells in atherosclerosis: clones but not carbon copies.

• DOI: 10.1016/j.jvssci.2021.02.002
• 发表时间: 2021
• 期刊: JVS-vascular science
• 作者: Espinosa-Diez C;Mandi V;Du M;Liu M;Gomez D
• 通讯作者: Gomez D

Association of activin A and postpartum blood pressure in peripartum cardiomyopathy.

围产期心肌病中激活素 A 与产后血压的关联。

• DOI: 10.1016/j.preghy.2023.10.002
• 发表时间: 2023
• 期刊: Pregnancy hypertension
• 作者: Koczo,Agnes;Marino,Amy;Polsinelli,VincenzoB;Alharethi,Rami;Damp,Julie;Ewald,Gregory;Givertz,MichaelM;Boehmer,John;Hanley-Yanez,Karen;Rana,Sarosh;Roh,Jason;McNamara,DennisM;IPACInvestigators
• 通讯作者: IPACInvestigators

Sex Differences in Myocardial Histology, Gene Expression, and Myocardial Recovery in Recent-Onset Cardiomyopathy.

新发心肌病心肌组织学、基因表达和心肌恢复的性别差异。

• DOI: 10.1016/j.jchf.2023.08.008
• 发表时间: 2023
• 期刊: JACC. Heart failure
• 作者: Koczo,Agnes;Rao,Anjali;Starling,RandallC;Cooper,LeslieT;Dec,GWilliam;Alexis,JeffreyD;Gorcsan,John;McTiernan,Charles;McNamara,DennisM
• 通讯作者: McNamara,DennisM