Racial/ethnic and socioeconomic disparities in biologic and clinical SLE outcomes

生物学和临床 SLE 结果的种族/民族和社会经济差异

• 批准号: 10668436
• 负责人: Maria Dall'Era
• 金额: $ 88万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-30 至 2027-09-29
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10668436
• 关键词: Racial; ethnic; socioeconomic; disparities; biologic

PROJECT SUMMARY We propose to extend the California Lupus Epidemiology Study (CLUES), which has established a racially and ethnically diverse cohort of over 450 individuals with systemic lupus erythematosus (SLE). The CLUES cohort was launched from the successful California Lupus Surveillance Project, which established the incidence and prevalence of SLE in San Francisco County. Individuals identified through the surveillance effort were invited to participate in the longitudinal CLUES cohort. The study currently includes i) extensive clinical data, including physician-assessed measures of SLE disease activity, medical history, SLE manifestations, and outcomes such as damage; ii) biologic specimens and data, including genetic, epigenetic, gene expression and environmental exposure information; and iii) data from structured interviews with participants covering sociodemographics, healthcare access and gaps, symptoms, disability, and a wide variety of patient-reported outcomes. This exceptionally broad and deep data collection has catalyzed a wide spectrum of SLE research studies, ranging from the examination of clinical and patient-reported outcomes in SLE to studies of DNA methylation and gene transcription across racially and ethnically diverse populations. Through data collection, analyses and dissemination, the overarching aim of the CLUES cohort is to advance our understanding of the epidemiology, biology, natural history, and outcomes of SLE, particularly among diverse racial, ethnic and socioeconomic groups. In the renewal period, our aims are 1) to continue longitudinal data collection on CLUES participants, including comprehensive patient-reported data, 2) to enhance and maintain a state-of-the-art biospecimen repository and provide access to this valuable resource to investigators, and 3) to conduct two special projects, one examining the metabolome during and after flares to gain insight into mechanisms of SLE disease activity, and one examining the natural history of disability across the activity spectrum, including how flares may affect disability trajectories. The overall project leverages outstanding institutional resources and builds on the proven track-record of the investigators in building a successful administrative and management infrastructure for CLUES, developing and maintaining longitudinal cohort studies, and creating effective systems for sharing clinical data and biospecimens. CLUES is unique because there are very few population-based studies of Asians or Hispanic-Americans with SLE, two groups that are disproportionately affected by the disease and who comprise a significant and growing proportion of the U.S. population. In addition, we continue to address disease flares, an area that is ripe for research and central to advancing knowledge about the natural history, outcomes, biologic mechanisms of SLE and related health disparities.

项目摘要 我们建议扩展加州狼疮流行病学研究（CLUES），该研究已经建立了一个种族和 超过450例系统性红斑狼疮（SLE）患者的种族多样性队列。CLUES队列 是从成功的加州狼疮监测项目启动的，该项目确定了发病率， 弗朗西斯科县SLE的患病率。通过监视工作确定的个人被邀请 参与纵向CLUES队列。该研究目前包括i）广泛的临床数据，包括 医生评估的SLE疾病活动度、病史、SLE表现和结局指标， 生物标本和数据，包括遗传、表观遗传、基因表达和环境 暴露信息;以及iii）来自与参与者的结构化访谈的数据， 医疗保健可及性和差距、症状、残疾和各种患者报告的结果。这 异常广泛和深入的数据收集促进了广泛的SLE研究， 从SLE的临床和患者报告结果的检查到DNA甲基化和基因表达的研究， 在不同种族和民族的人群中进行转录。通过数据收集、分析和 传播，CLUES队列的首要目标是促进我们对流行病学的理解， SLE的生物学、自然史和结局，特别是在不同种族、民族和社会经济背景中 组在续约期间，我们的目标是：1）继续对CLUES参与者进行纵向数据收集， 包括全面的患者报告数据，2）增强和保持最先进的生物标本 储存库，并向调查人员提供这一宝贵资源，以及3）开展两个特别项目， 一个是在发作期间和之后检查代谢组以深入了解SLE疾病活动的机制， 另一个是研究整个活动范围内残疾的自然史，包括耀斑如何影响 残疾轨迹。整个项目利用了优秀的机构资源，并建立在经过验证的 调查人员在建立成功的行政和管理基础设施方面的业绩记录， CLUES，开发和维护纵向队列研究，并创建有效的共享系统 临床数据和生物样本。CLUES是独一无二的，因为很少有基于亚洲人的研究 或患有SLE的西班牙裔美国人，这两个群体受疾病的影响不成比例， 在美国人口中所占的比例越来越大。此外，我们继续处理疾病 耀斑，一个研究成熟的领域，是推进自然历史，成果， SLE的生物学机制和相关的健康差异。