Epidemiology of Lupus: Longitudinal Studies in Population-Based Cohorts - 2019

狼疮流行病学：基于人群的队列纵向研究 - 2019

• 批准号: 10201409
• 负责人: Maria Dall'Era
• 金额: $ 90万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10201409
• 关键词: Epidemiology; Lupus; Longitudinal; Studies; Population

We propose to extend the California Lupus Epidemiology Study (CLUES), which has established a racially/ethnically diverse cohort of over 400 individuals with systemic lupus erythematosus (SLE). The CLUES cohort builds on the successful California Lupus Surveillance Project, which established the incidence and prevalence of SLE in San Francisco County. Individuals identified through the surveillance effort were invited to participate in the longitudinal CLUES cohort. The study currently includes i) extensive clinical data, including physician-assessed measures of SLE disease activity, manifestations, and outcomes such as damage; ii) biologic data, including genetic, epigenetic, gene expression and environmental exposure information; and iii) data from structured interviews with participants covering sociodemographics, healthcare access and gaps, symptoms, disability, and a wide variety of patient-reported outcomes. This exceptionally broad and deep data collection has catalyzed a wide spectrum of SLE research studies, ranging from the examination of clinical and patient-reported outcomes in SLE to studies of DNA methylation across diverse racial/ethnic populations. Through data collection, analyses and dissemination, the overarching goal of CLUES is to advance our understanding of the natural history, treatment, outcomes and biology of SLE among diverse racial/ethnic and socioeconomic populations. In the renewal period, our aims are 1) lo continue longitudinal data collection on CLUES participants, including comprehensive patient-reported data, 2) to enhance and maintain a state-of-the-art biospecimen repository and provide access lo this resource to investigators, 3) to catalyze research on health disparities in vulnerable populations with SLE, including racial/ethnic minorities and those with low socioeconomic status, serving as a hub that brings together investigators and fosters high-impact, novel epidemiologic studies of the disease, and 4) to conduct two special projects, one examining the biology of SLE disease flares through investigations of epigenetic modifications during flares and after their resolution, and one examining the association of psychosocial stress with disease activity and flares. The overall project leverages outstanding institutional resources and builds on the proven track-record of the investigators in building a successful administrative and management infrastructure for CLUES, developing and maintaining longitudinal cohort studies, and creating effective systems for sharing clinical data and biospecimens. CLUES is unique because there are currently no population-based studies of Asians or Hispanic-Americans with SLE, two groups that are disproportionately affected by the disease and who comprise a significant and growing proportion of the U.S. population. In addition, the proposed special projects address disease flares, an area that is ripe for research and central lo advancing knowledge about the natural history, outcomes, biologic mechanisms of SLE and related health disparities.

我们建议扩展加州狼疮流行病学研究（CLUES），该研究已经建立了一个 超过400名患有系统性红斑狼疮（SLE）的个体的种族/人种多样化队列。的线索 队列建立在成功的加州狼疮监测项目的基础上，该项目确定了发病率， 弗朗西斯科县SLE的患病率。通过监视工作确定的个人被邀请 参与纵向CLUES队列。该研究目前包括i）广泛的临床数据，包括 医生评估的SLE疾病活动、表现和结果（如损害）的指标; ii） 生物数据，包括遗传、表观遗传、基因表达和环境暴露信息;以及iii） 来自参与者结构化访谈的数据，涵盖社会人口统计学、医疗保健获取和差距， 症状、残疾和各种患者报告的结局。这些异常广泛和深入的数据 收集已经催化了广泛的SLE研究，从临床检查， SLE患者报告的结果与不同种族/民族人群的DNA甲基化研究结果之间的关系。 通过数据收集、分析和传播，CLUES的总体目标是促进我们的 了解不同种族/民族之间SLE的自然史、治疗、结局和生物学， 社会经济人口。在更新期间，我们的目标是：1）继续纵向收集数据， CLUES参与者，包括全面的患者报告数据，2）增强和保持最新技术水平 生物标本库，并提供访问这个资源的研究人员，3）催化研究健康 SLE易感人群的差异，包括种族/少数民族和低 社会经济地位，作为一个枢纽，汇集调查人员和培养高影响力，新颖的 疾病的流行病学研究，以及4）进行两个特殊项目，一个是检查SLE的生物学 通过调查疾病爆发期间和之后的表观遗传修饰， 研究社会心理压力与疾病活动和发作的关系。整个项目利用 优秀的机构资源，并建立在调查人员在建立一个 为CLUES建立成功的行政和管理基础设施， 队列研究，并建立有效的系统，共享临床数据和生物标本。线索是独一无二的 由于目前还没有对亚洲人或西班牙裔美国人SLE患者进行基于人群的研究， 受艾滋病影响最大的群体， 美国人口此外，拟议的特别项目涉及疾病突发，这是一个时机已经成熟的领域， 研究和中心旨在提高对SLE自然史、结局、生物学机制的认识 以及相关的健康差距。

项目成果

Molecular pathways identified from single nucleotide polymorphisms demonstrate mechanistic differences in systemic lupus erythematosus patients of Asian and European ancestry.

• DOI: 10.1038/s41598-023-32569-6
• 发表时间: 2023-04-01
• 期刊: SCIENTIFIC REPORTS
• 影响因子: 4.6
• 作者: Owen, Katherine A.;Bell, Kristy A.;Price, Andrew;Bachali, Prathyusha;Ainsworth, Hannah;Marion, Miranda C.;Howard, Timothy D.;Langefeld, Carl D.;Shen, Nan;Yazdany, Jinoos;Dall'era, Maria;Grammer, Amrie C.;Lipsky, Peter E.
• 通讯作者: Lipsky, Peter E.

Differential regulation of the interferon response in systemic lupus erythematosus distinguishes patients of Asian ancestry.

• DOI: 10.1136/rmdopen-2023-003475
• 发表时间: 2023-09
• 期刊: RMD OPEN
• 影响因子: 6.2
• 作者: Rector, Ian;Owen, Katherine A.;Bachali, Prathyusha;Hubbard, Erika;Yazdany, Jinoos;Dall'era, Maria;Grammer, Amrie C.;Lipsky, Peter E.
• 通讯作者: Lipsky, Peter E.