Emerging role of heme and heme degradation products in the modulation of cardiac ion channels

血红素和血红素降解产物在心脏离子通道调节中的新作用

• 批准号: 10668491
• 负责人: Nirakar Sahoo
• 金额: $ 14.8万
• 依托单位: UNIVERSITY OF TEXAS RIO GRANDE VALLEY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-23 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10668491
• 关键词: Acute; Address; Autophagocytosis; Biliverdine; Binding; Biological Assay; Calcium-Activated Potassium Channel; Carbon Monoxide; Cardiac; Cardiovascular Diseases; Cardiovascular Physiology; Cardiovascular system; Cause of Death; Cell membrane; Cells; Cessation of life; Cysteine; Cytochromes; Data; Deletion Mutagenesis; Economic Burden; Electrophysiology (science); Environment; Ethers; Excision; Funding; Gases; Genes; Goals; Health; Heme; Hemin; Hemoglobin; Hemp; Hispanic; Histidine; Human; Imaging Techniques; Immunohistochemistry; Intake; Ion Channel; Ion Channel Protein; Iron; Knowledge; Ligation; Link; Lysosomes; Meat; Minority-Serving Institution; Mitochondria; Molecular; Mutagenesis; Myoglobin; Outcomes Research; Oxygenases; Physiological; Play; Potassium Channel; Probability; Process; Proteins; Protoporphyrins; Regulation; Reporting; Research; Role; Signal Transduction; Signaling Molecule; Soluble Guanylate Cyclase; System; Testing; Transfection; United States; Work; cardiovascular disorder risk; cofactor; experimental study; insight; iron protoporphyrin IX; large-conductance calcium-activated potassium channels; mutant; non-genomic; patch clamp; porphyrin a; red meat consumption; voltage

PROJECT SUMMARY/ABSTRACT Over the past years, research from around the globe has focused on the consumption of red meat and the risk of cardiovascular disease. This positive correlation has been linked to excess heme and its degradation product iron (Fe2+), which are abundant in red meat. Heme serves as a stable cofactor consisting of an iron (Fe2+) coordinated to a porphyrin-IX, often conferring gas sensitivity as exemplified in cytochromes, hemoglobin, myoglobin, and soluble guanylyl cyclase. Excess heme in the system is catabolized by heme oxygenase, which produces carbon monoxide (CO), iron and biliverdin. Emerging evidence, however, suggests a new paradigm of the heme function; intracellular free heme can act as a potent non-genomic acute signaling molecule capable of directly regulating ion channel proteins. Despite the probable physiological and pathophysiological role of heme and other hemp-derived molecules, our knowledge of the acute targets/effectors of heme signaling in the cardiovascular system is severely limited. The goal of this proposal is to define the impacts of heme and heme degradation products (CO) on cardiovascular function by addressing the following questions 1) How do heme and CO impact cardiac ion channels? 2) Does excess heme and CO alter mitophagy in cardiac cells?

项目总结/文摘

项目成果

Analysis of Sanitizer Rotation on the Susceptibility, Biofilm Forming Ability and Caco-2 Cell Adhesion and Invasion of Listeria.

• DOI: 10.3390/pathogens11090961
• 发表时间: 2022-08-24
• 期刊: Pathogens (Basel, Switzerland)
• 作者: Rahman MA;Sahoo N;Yemmireddy V
• 通讯作者: Yemmireddy V

A rationally designed synthetic antimicrobial peptide against Pseudomonas-associated corneal keratitis: Structure-function correlation.

• DOI: 10.1016/j.bpc.2022.106802
• 发表时间: 2022-07
• 期刊: BIOPHYSICAL CHEMISTRY
• 影响因子: 3.8
• 作者: Mohid, Sk Abdul;Sharma, Prerana;Alghalayini, Amani;Saini, Tripti;Datta, Debarun;Willcox, Mark D. P.;Ali, Haydar;Raha, Sreyan;Singha, Achintya;Lee, DongKuk;Sahoo, Nirakar;Cranfield, Charles G.;Roy, Sanhita;Bhunia, Anirban
• 通讯作者: Bhunia, Anirban

Mechanistic insight into functionally different human islet polypeptide (hIAPP) amyloid: the intrinsic role of the C-terminal structural motifs.

对功能不同的人胰岛多肽 (hIAPP) 淀粉样蛋白的机制洞察：C 端结构基序的内在作用。

• DOI: 10.1039/d2cp01650h
• 发表时间: 2022
• 期刊: Physical chemistry chemical physics : PCCP
• 作者: Sarkar,Dibakar;Maity,NarayanChandra;Shome,Gourav;Varnava,KyriakosGabriel;Sarojini,Vijayalekshmi;Vivekanandan,Subramanian;Sahoo,Nirakar;Kumar,Sourav;Mandal,AtinKumar;Biswas,Ranjit;Bhunia,Anirban
• 通讯作者: Bhunia,Anirban