Surround-mediated temporal and spatial filtering by retinal ganglion receptive fields shape the information encoded in the output of the retina.

视网膜神经节感受野的环绕介导的时间和空间过滤塑造了视网膜输出中编码的信息。

• 批准号: 10669255
• 负责人: Norianne Theresa Ingram
• 金额: $ 7.38万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-16 至 2024-08-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10669255
• 关键词: Accounting; Affect; Behavioral; Biophysics; Brain; Cells; Code; Data; Dependence; Detection; Dimensions; Future; Human; Interneurons; Kinetics; Language; Lateral; Light; Lighting; Link; Measures; Mediating; Modeling; Non-linear Models; Output; Perception; Photoreceptors; Phototransduction; Play; Primates; Process; Property; Publishing; Retina; Retinal Ganglion Cells; Rodent; Role; Route; Scientist; Sensory; Shapes; Signal Transduction; Source; Stimulus; Testing; Vertebrate Photoreceptors; Vision; Visual; Visual Cortex; Visual Perception; antagonist; biophysical model; cell type; detection limit; experience; experimental study; extrastriate visual cortex; falls; functional outcomes; horizontal cell; insight; light intensity; neural circuit; receptive field; response

Project Abstract Scientists are starting to decode the languages of neural circuits and are finding that the limits of perception are defined by the circuits that detect, process, and relay stimuli information. In vision, understanding the how a stimulus is represented at the output of the retina and how that representation changes with light conditions is key to defining the information content passed to the cortex. Retinal ganglion cells (RGCs) are responsible for performing the last circuit computations in the retina and generating and relaying light information to the cortex. A defining feature of RGC sensitivity is a receptive field with center-surround antagonism. These types of circuits are mediated by lateral inhibition so that stimuli detected in the surround modulate those detected in the center. Since the original discovery of center-surround antagonism in the retina, it has been shown in multiple model species that surround interactions are light dependent. While studies have begun to reveal the circuit mechanisms responsible for the light dependence of receptive fields, we still lack a complete understanding of how spatial and temporal features of receptive fields change with light conditions. I propose to study how light controls the spatial- and temporal-filtering mediated by the receptive field surround and how that shapes the final output of primate retina. In Aim1 I will measure the light dependence of the surround-mediated filtering and determine the functional detections limits at the level of retinal output. Aim2 will identify how circuit routing determines access to inner and outer sources of lateral inhibition and other light dependent mechanisms adjusting the strength of surround modulations in the spatial and temporal domains. Fully understanding the dynamic properties of surround-mediating filtering in primate retina not only adds to our understanding of how lateral inhibition affects sensory encoding and detection, but importantly, will also provide new insights into how retinal circuits define the limits of human perception.

项目摘要 科学家们开始破译神经回路的语言，并发现 感知是由检测、处理和传递刺激信息的电路定义的。在视觉上， 了解刺激是如何在视网膜的输出端表现出来的，以及它是如何表现出来的 光条件的变化是定义传递给大脑皮层的信息内容的关键。视网膜 神经节细胞(RGC)负责执行视网膜和 产生光信息并将其传递到大脑皮层。研资局敏感度的一个定义特征是 具有中心-周围对抗性的接受场。这些类型的回路是由侧支传导的 抑制，以便在周围检测到的刺激调制在中心检测到的刺激。自.以来 最初在视网膜中发现了中心-周围拮抗作用，目前已有多种模型显示 围绕相互作用的物种依赖于光。虽然研究已经开始揭示这种电路 对于光依赖感受场的机制，我们还缺乏一个完整的 了解感受野的空间和时间特征如何随光条件变化。我 建议研究光如何控制感受野调节的空间和时间过滤 以及它如何塑造灵长类视网膜的最终输出。在Aim1中，我将测量光线 环绕式滤波的依赖性，并确定在 视网膜输出的水平。AIM2将确定电路路由如何确定对内部和外部的访问 侧向抑制的来源和其他调节周围强度的光依赖机制 空间和时间域中的调制。充分了解的动态特性 灵长类视网膜的环绕调节过滤不仅增加了我们对侧向抑制的理解 影响感官编码和检测，但重要的是，它还将提供对视网膜如何 电路定义了人类感知的极限。