Biomarkers and Altered Metabolic Pathways during Sleep Loss and Circadian Disruption
睡眠不足和昼夜节律紊乱期间的生物标志物和代谢途径的改变
基本信息
- 批准号:10668411
- 负责人:
- 金额:$ 16.58万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-02-19 至 2024-07-31
- 项目状态:已结题
- 来源:
- 关键词:AccelerationAdultAffectAmericanAnxietyAreaAwardBenchmarkingBiochemicalBiochemical PathwayBioinformaticsBiologicalBiological MarkersBloodBranched-Chain Amino AcidsCardiometabolic DiseaseChronicCircadian DysregulationCircadian RhythmsCircadian desynchronyClinical assessmentsCommunitiesDataData AnalysesDevelopmentDiabetes MellitusDiagnosisDiseaseDrug abuseEpidemicFingerprintFundingGlucoseGoalsHealthHealth BenefitHourHumanIndividualInflammationInterventionLaboratoriesLinkMental DepressionMetabolic DiseasesMetabolic PathwayObesityOutcomeParticipantPersonsPhenotypePhysiologicalPlasmaPrevalencePreventionProteinsProteomeProteomicsProtocols documentationPublic HealthPublishingRecommendationResearchResearch TrainingRiskSamplingScienceSensitivity and SpecificitySleepSleep DeprivationSleep DisordersSystemTestingTimeTrainingTranslationsUnited States National Institutes of HealthWakefulnessWeight GainWorkadequate sleepagedbench to bedsidebiomarker identificationbiomarker validationcardiometabolic riskcardiometabolismcircadianclinical biomarkersclinical diagnosisclinical translationcohortdiabetes riskfatty acid metabolismimprovedinsulin sensitivitymetabolomemetabolomicsnovelpersonalized medicinepoor sleepprimary care providerprimary outcomeprogramsresponsesecondary outcomeshift worktimelineweek trial
项目摘要
PROJECT SUMMARY/ABSTRACT
Approximately 50-70 million Americans suffer from sleep and wakefulness disorders and over 35% of Americans
sleep less than the recommended 7 hours per night. Additionally, ~20% of adults in the work force are shift-
workers and therefore have elevated risk of circadian misalignment (i.e. sleeping during the biological day and
wakefulness during the biological night). Health problems associated with insufficient sleep and circadian
misalignment include inflammation, depression and anxiety, drug abuse, reduced insulin sensitivity, diabetes,
and obesity. While the contribution of sleep to overall health is well recognized, many primary care providers fail
to diagnose or recognize sleep and circadian disorders and estimates show undiagnosed sleep disorders are more
prevalent than diagnosed sleep disorders. Currently, no clinical biomarkers of overall sleep and circadian health
exist. Developing such biomarkers has the potential to: 1) improve diagnosis of sleep and circadian disorders;
2) identify biochemical mechanisms underlying increased risk of cardiometabolic disease associated with
insufficient sleep and circadian misalignment; and 3) inform novel sleep and circadian based countermeasures.
Long-term, biomarkers of sleep and circadian health could also support the development of personalized
medicine, in part, by identifying individuals most likely to benefit from sleep and circadian based interventions.
The overall goal of this K01 is to identify biomarkers of sleep loss and circadian misalignment, and assess the
impact of increased sleep time on these biomarkers. I will use samples from two previously completed NIH-
funded laboratory based protocols to identify putative biomarkers of insufficient sleep and circadian
misalignment using plasma metabolomics and proteomics. I will also assess the plasma metabolome and insulin
sensitivity in a four-week trial that increases nightly sleep duration to the recommended ≥7 hours sleep/night in
habitual short-sleepers to determine if my identified biomarkers can discriminate these individuals between
baseline insufficient sleep and post-increased sleep time and if increasing sleep time improves insulin sensitivity.
This award will provide key training in four areas: 1) bioinformatics; 2) omics; 3) clinical translational sleep and
circadian studies and interventions; and 4) professional development, and will provide essential preliminary
data for an NIH R01 to help me launch an independent research program. The proposed outcomes support the
2011 NIH Sleep Disorders Research Plan to “enable sleep and circadian research training to inform science in
cross-cutting domains, accelerate the pace of discovery, and the translation of enhanced therapies from bench to
bedside to community”.
项目总结/文摘
项目成果
期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Christopher Michael Depner其他文献
Christopher Michael Depner的其他文献
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{{ truncateString('Christopher Michael Depner', 18)}}的其他基金
Biomarkers of Habitual Short Sleep and Related Cardiometabolic Risk
习惯性短睡眠和相关心脏代谢风险的生物标志物
- 批准号:
10734674 - 财政年份:2023
- 资助金额:
$ 16.58万 - 项目类别:
Biomarkers and Altered Metabolic Pathways during Sleep Loss and Circadian Disruption
睡眠不足和昼夜节律紊乱期间的生物标志物和代谢途径的改变
- 批准号:
10292870 - 财政年份:2021
- 资助金额:
$ 16.58万 - 项目类别:
Biomarkers and Altered Metabolic Pathways during Sleep Loss and Circadian Disruption
睡眠不足和昼夜节律紊乱期间的生物标志物和代谢途径的改变
- 批准号:
10475139 - 财政年份:2021
- 资助金额:
$ 16.58万 - 项目类别:
Biomarkers and Altered Metabolic Pathways during Sleep Loss and Circadian Disruption
睡眠不足和昼夜节律紊乱期间的生物标志物和代谢途径的改变
- 批准号:
10251958 - 财政年份:2021
- 资助金额:
$ 16.58万 - 项目类别:
Biomarkers and Altered Metabolic Pathways during Sleep Loss and Circadian Disruption
睡眠不足和昼夜节律紊乱期间的生物标志物和代谢途径的改变
- 批准号:
10018104 - 财政年份:2019
- 资助金额:
$ 16.58万 - 项目类别:
Mechanisms of Insufficient Sleep Contributing to Metabolic Disease Risk and Impact from Weekend Recovery Sleep
睡眠不足导致代谢疾病风险的机制以及周末恢复睡眠的影响
- 批准号:
9192556 - 财政年份:2017
- 资助金额:
$ 16.58万 - 项目类别:
Mechanisms of Insufficient Sleep Contributing to Metabolic Disease Risk and Impact from Weekend Recovery Sleep
睡眠不足导致代谢疾病风险的机制以及周末恢复睡眠的影响
- 批准号:
9414732 - 财政年份:2017
- 资助金额:
$ 16.58万 - 项目类别:
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