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Bioinformatics and Biostatistics Core

生物信息学和生物统计学核心

基本信息

批准号：
10668970
负责人：
Jeffrey Peter Townsend
金额：
$ 22.2万
依托单位：
YALE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-22 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10668970
关键词：
Address Adverse event Basic Science Bioinformatics Biometry Biostatistics Core Clinical Clinical Research Clinical Sciences Clinical Trials Collaborations Collection Communication Computers Computing Methodologies Consultations Data Data Analyses Databases Development Employment Ensure Experimental Designs Faculty Fox Chase Cancer Center Funding Futility Goals Head and Neck Cancer Head and neck structure Individual Informatics Investigation Laboratories Leadership Malignant Neoplasms Manuscripts Medicine Methodology Methods Monitor Monitoring Clinical Trials Patient Care Physicians Play Policies Population Population Sciences Population Study Prevention strategy Privacy Procedures Program Development Publications Randomized Reproduction spores Research Research Personnel Research Proposals Resources Role Safety Sample Size Schedule Science Sequence Analysis Services Suggestion System Translational Research Work Writing Yale Cancer Center career development data management data mining design frontier genomic data innovation meetings member multidimensional data next generation next generation sequencing pre-clinical programs research and development therapy resistant tool translational study treatment strategy web-accessible

项目摘要

Project Summary The goal of the Biostatistics and Bioinformatics Core (Core C) is to address the statistical design and analysis needs of the Yale SPORE in Head and Neck Cancer (YHN-SPORE) Projects, the Cores, the Developmental Research Program (DRP), and the Career Development Program (CDP). To accomplish this goal we have assembled a highly interactive team of cancer biostatisticians and bioinformaticians who will work collaboratively with basic, clinical, translational, and population science researchers to advance the frontiers of cancer medicine. The specific aims of the Biostatistics and Bioinformatics Core are: Aim 1: Provide collaboration and consulting in the design, execution, monitoring and analysis of basic, translational, population, and clinical studies for YHN-SPORE. Aim 2: Oversee and coordinate the collection, management, and analysis of data. Ensure that data collected on all YHN-SPORE studies are of high quality, are evaluated with bioinformatic and statistical rigor, are accessible within SPORE-affiliated collaborative groups, ultimately enabling the widest accessibility that is appropriate given publication and privacy concerns. For Aim 1, the Core will work closely with the investigators to analyze clinical trial and pre-clinical data, next generation sequencing data, and bioinformatics data mining. Services provided by the Core will range from planning and design activities to consulting on specific analytic questions. The Core will address the analytic and informatics questions arising from the YHN-SPORE projects. The Core will rigorously design and monitor clinical trials for safety, efficacy and futility. The Core will schedule regular meetings with the YHN-SPORE investigators, and maintain an open-door policy for any biostatistical and bioinformatics questions. The Core will conduct interim and final analyses, develop new statistical and bioinformatics methodology as needed, provide timely suggestions to YHN-SPORE investigators, and thus play an important role in the entire study. Biostatistics and Bioinformatics is also a key partner in the YHN-SPORE with representation on their Senior Leadership Team and participation in all core meetings. For Aim 2, The Core will work with the Yale Cancer Center (YCC), Yale Center for Analytical Sciences (YCAS), Fox Chase Cancer Center (FCCC) and its quantitative cores to facilitate communication among YHN-SPORE researchers, creating and implementing web-accessible databases for collecting, storing and accessing the various types of data (e.g. laboratory, clinical, population, and genomic data) that will be generated for the YHN-SPORE projects. The Core is highly integrated with the projects, and will have regular meetings with project investigators, as well as YCAS data managers, to evaluate the data generated from the studies and ensure accurate and up-to-date data management.

项目概要生物统计学和生物信息学核心（核心 C）的目标是解决统计设计和分析问题耶鲁 SPORE 在头颈癌 (YHN-SPORE) 项目、核心、发展方面的需求研究计划（DRP）和职业发展计划（CDP）。为了实现这个目标，我们有组建了一支由癌症生物统计学家和生物信息学家组成的高度互动的团队，他们将开展工作与基础、临床、转化和人口科学研究人员合作，推进前沿研究癌症医学。生物统计学和生物信息学核心的具体目标是：目标 1：在基础、执行、监控和分析方面提供协作和咨询， YHN-SPORE 的转化、群体和临床研究。目标 2：监督和协调数据的收集、管理和分析。确保收集的数据所有 YHN-SPORE 研究都是高质量的，经过生物信息学和统计学的严格评估，可在 SPORE 附属协作组内访问，最终实现最广泛的可访问性考虑到出版和隐私问题是适当的。对于目标 1，核心将与研究人员密切合作，分析临床试验和临床前数据，下一步生成测序数据和生物信息学数据挖掘。核心提供的服务范围包括规划和设计活动到就具体分析问题进行咨询。核心将解决分析以及 YHN-SPORE 项目产生的信息学问题。核心将严格设计和监控安全性、有效性和无效性的临床试验。核心将安排与 YHN-SPORE 的定期会议研究人员，并对任何生物统计和生物信息学问题保持开放政策。核心将进行中期和最终分析，根据需要开发新的统计和生物信息学方法，为YHN-SPORE研究者提供及时的建议，从而在整个研究中发挥重要作用。生物统计学和生物信息学也是 YHN-SPORE 的重要合作伙伴，并在其高级会议上有代表领导团队并参与所有核心会议。对于目标 2，The Core 将与耶鲁大学癌症中心合作中心 (YCC)、耶鲁大学分析科学中心 (YCAS)、福克斯蔡斯癌症中心 (FCCC) 及其定量核心，以促进 YHN-SPORE 研究人员之间的交流，创建和实施可通过网络访问的数据库，用于收集、存储和访问各种类型的数据（例如实验室、临床、人口和基因组数据），这些数据将为 YHN-SPORE 项目生成。核心高度与项目相结合，并将与项目调查人员定期举行会议，并利用 YCAS 数据管理人员，评估研究生成的数据并确保数据准确和最新管理。