Preventing Weight Gain and Diabetes in People with HIV in South Africa

预防南非艾滋病毒感染者体重增加和糖尿病

• 批准号: 10668540
• 负责人: Jennifer Manne-Goehler
• 金额: $ 19.61万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-14 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10668540
• 关键词: Acceleration; Acquired Immunodeficiency Syndrome; Address; Adopted; Africa; Africa South of the Sahara; Anthropometry; Area; Behavioral; Behavioral Model; Body Weight Changes; Cardiovascular system; Caring; Chronic; Chronic Disease; Clinical; Clinical Trials; Collaborations; Communicable Diseases; Conduct Clinical Trials; Data; Data Analyses; Demographic and Health Surveys; Diabetes Mellitus; Diabetes prevention; Dietary Practices; Disease; Educational Status; Epidemic; Epidemiologic Methods; Epidemiology; Feasibility Studies; Feedback; Foundations; Funding; General Hospitals; Glucose Intolerance; Glycosylated hemoglobin A; Goals; HIV; Health; Health system; Home; Intake; International; Intervention; Intervention Studies; Intervention Trial; Interview; Lead; Massachusetts; Measures; Medicine; Mentors; Mentorship; Metabolic; Metabolic Diseases; Morbidity - disease rate; Obesity; Obesity Epidemic; Observational Study; Overweight; Paper; Persons; Pharmaceutical Preparations; Physical activity; Physicians; Pilot Projects; Population; Positioning Attribute; Preventive; Public Health; Publications; Publishing; Randomized; Regimen; Reporting; Research; Research Institute; Research Priority; Risk Factors; Scientist; South Africa; Testing; Time; Training; Treatment Efficacy; Trust; United States National Institutes of Health; Weight; Weight Gain; Woman; acceptability and feasibility; antiretroviral therapy; arm; care systems; career; clinical trial analysis; cohort; data integration; design; diabetes risk; efficacy testing; excessive weight gain; experience; fast food; feasibility testing; global health; glucose tolerance; glycosylated serum albumin; improved; increased appetite; low and middle-income countries; men; mortality; multidisciplinary; nutrition; obesity prevention; observational cohort study; pharmacologic; prevent; prospective; prototype; public health relevance; skill acquisition; skills; standard of care; sugar; sweetened beverage; therapy design; therapy development; treatment as usual; treatment program

PROJECT SUMMARY Background: Obesity and diabetes are important risk factors for morbidity and mortality in people with HIV (PWH), especially in sub-Saharan Africa where health systems are already grappling with a rapid rise in metabolic disease. Dolutegravir (DTG)-based antiretroviral therapy (ART) has recently been adopted as the first-line regimen in most of the region, despite evidence that it is associated with excess weight gain. While the HIV care system offers a capable health systems platform, obesity and diabetes prevention is not a current focus of care paradigms. Candidate: I am a Clinical Fellow in Infectious Diseases at Massachusetts General Hospital and a physician-scientist with doctoral-level training in global health epidemiology and a strong track record of published observational research. However, my recent experiences caring for PWH have led to a desire to gain new skills in the design and execution of interventional trials to prevent metabolic disease in this population. My overarching career goal is to become an independent, NIH-funded physician-scientist with expertise in the metabolic complications of treated HIV, and in developing and testing clinical interventions to prevent these complications. Training: To achieve research independence, I will require additional training in 1) obesity medicine and diabetes prevention, 2) behavioral model-based intervention design, and 3) the conduct and analysis of clinical trials to prevent metabolic complications of HIV. Mentors: My training and research plans will be overseen by my primary mentor Dr. Mark Siedner, who has extensive mentoring experience and conducts both observational cohort studies and clinical trials in South Africa. Drs. Janet Lo (obesity medicine and diabetes prevention), Christina Psaros (behavioral model-based intervention design), and Deborah Wexler (the conduct and analysis of clinical trials) will serve as co-mentors to provide additional focused expertise. I will also receive annual feedback from my Scientific Advisory Board, which includes Drs. Rochelle Walensky, Naomi Levitt, Robert Parker, and Till Bärnighausen. Research: With guidance from my team of mentors, I will explore the metabolic effects of DTG among PWH in South Africa and develop and pilot an intervention to mitigate these complications through three specific aims: 1) To determine the behavioral correlates of weight change and glucose intolerance for PWH transitioning to DTG-based ART in South Africa; 2) To develop an acceptable and contextually appropriate intervention to prevent weight gain and diabetes in PWH on DTG-based ART in South Africa; and 3) To conduct a factorial-randomized feasibility study of interventions to prevent weight gain and diabetes among PWH on DTG-based ART versus usual care. We will carry out this research through existing collaborations with the Wellcome Trust-funded Africa Health Research Institute (AHRI). Through this period of training and research, I will be well positioned to achieve research independence and plan to submit an NIH R01 application in the fourth year of this project to test the efficacy of an intervention to prevent weight gain and diabetes in PWH in South Africa.

项目概要 背景：肥胖和糖尿病是艾滋病毒感染者发病和死亡的重要危险因素 (PWH)，特别是在撒哈拉以南非洲地区，那里的卫生系统已经在努力应对感染率迅速上升的问题 代谢性疾病。基于多替拉韦（DTG）的抗逆转录病毒疗法（ART）最近被采用作为 尽管有证据表明它与体重过度增加有关，但该地区大部分地区仍将其作为一线治疗方案。虽然 艾滋病毒护理系统提供了一个强大的卫生系统平台，肥胖和糖尿病的预防并不是当前的问题 护理范式的重点。候选人：我是马萨诸塞州综合医院传染病临床研究员 医院和一位接受过全球健康流行病学博士级培训并拥有强大跟踪能力的医师科学家 已发表的观察性研究的记录。然而，我最近照顾感染者的经历让我意识到 渴望获得设计和执行介入试验的新技能，以预防代谢疾病 人口。我的首要职业目标是成为一名独立的、由 NIH 资助的医师科学家 治疗艾滋病毒代谢并发症方面的专业知识，以及开发和测试临床干预措施以 预防这些并发症。培训：为了实现研究独立性，我需要额外的培训 1) 肥胖医学和糖尿病预防，2) 基于行为模型的干预设计，3) 进行和分析预防艾滋病毒代谢并发症的临床试验。导师：我的训练和 研究计划将由我的主要导师 Mark Siedner 博士监督，他拥有广泛的指导 经验并在南非进行观察性队列研究和临床试验。博士。罗珍妮 （肥胖医学和糖尿病预防），Christina Psaros（基于行为模型的干预设计）， Deborah Wexler（临床试验的实施和分析）将作为共同导师，提供额外的帮助 专注的专业知识。我还将收到我的科学顾问委员会的年度反馈，其中包括博士。 罗谢尔·瓦伦斯基、娜奥米·莱维特、罗伯特·帕克和蒂尔·巴尼格豪森。研究：在我的指导下 我将与导师团队一起探索 DTG 对南非 PWH 的代谢影响，并进行开发和试点 通过三个具体目标来减轻这些并发症的干预措施：1）确定行为 南非 PWH 过渡到基于 DTG 的 ART 时体重变化和葡萄糖耐受不良的相关性； 2) 制定可接受且适合具体情况的干预措施，以预防体重增加和糖尿病 南非 PWH 开展基于 DTG 的 ART 治疗； 3) 进行阶乘随机可行性研究 与常规护理相比，基于 DTG 的 ART 预防感染者体重增加和糖尿病的干预措施。我们将 通过与威康信托基金会资助的非洲健康研究的现有合作来开展这项研究 研究所（AHRI）。通过这段时间的训练和研究，我将能够很好地实现研究目标 独立性，并计划在该项目的第四年提交NIH R01申请，以测试其功效 一项旨在预防南非感染者体重增加和糖尿病的干预措施。

项目成果

Impact of diabetes on longevity and disability-free life expectancy among older South African adults: A prospective longitudinal analysis.

• DOI: 10.1016/j.diabres.2023.110577
• 发表时间: 2023-03
• 期刊: DIABETES RESEARCH AND CLINICAL PRACTICE
• 影响因子: 5.1
• 作者: Payne, Collin F.;Liwin, Lilipramawanty K.;Wade, Alisha N.;Houle, Brian;Du Toit, Jacques D.;Flood, David;Manne-Goehler, Jennifer
• 通讯作者: Manne-Goehler, Jennifer

Diabetes risk and provision of diabetes prevention activities in 44 low-income and middle-income countries: a cross-sectional analysis of nationally representative, individual-level survey data.

• DOI: 10.1016/s2214-109x(23)00348-0
• 发表时间: 2023-10
• 期刊: LANCET GLOBAL HEALTH
• 影响因子: 34.3
• 作者: Rahim, Nicholas Errol;Flood, David;Marcus, Maja E.;Theilmann, Michaela;Aung, Taing N.;Agoudavi, Kokou;Kumararyal, Krishna;Bahendeka, Silver;Bicaba, Brice;Bovet, Pascal;Diallo, Alpha Oumar;Farzadfar, Farshad;Guwatudde, David;Houehanou, Corine;Houinato, Dismand;Hwalla, Nahla;Jorgensen, Jutta;Kagaruki, Gibson Bernard;Mayige, Mary;Wong-McClure, Roy;Larijani, Bagher;Moghaddam, Sahar Saeedi;Mwalim, Omar;Mwangi, Kibachio Joseph;Sarkar, Sudipa;Sibai, Abla M.;Sturua, Lela;Wesseh, Chea;Geldsetzer, Pascal;Atun, Rifat;Vollmer, Sebastian;Baernighausen, Till;Davies, Justine;Ali, Mohammed K.;Seiglie, Jacqueline A.;Manne-Goehler, Jennifer
• 通讯作者: Manne-Goehler, Jennifer

Improving health outcomes of people with diabetes: target setting for the WHO Global Diabetes Compact.

• DOI: 10.1016/s0140-6736(23)00001-6
• 发表时间: 2023-04-15
• 期刊: Lancet (London, England)

Characteristics and efficacy of physical activity interventions to improve cardiometabolic and psychosocial outcomes in people living with HIV in sub-Saharan Africa: a protocol for a systematic review.

• DOI: 10.1186/s13643-023-02186-5
• 发表时间: 2023-02-23
• 期刊: Systematic reviews
• 影响因子: 3.7

The state of diabetes treatment coverage in 55 low-income and middle-income countries: a cross-sectional study of nationally representative, individual-level data in 680 102 adults.

• DOI: 10.1016/s2666-7568(21)00089-1
• 发表时间: 2021-06
• 期刊: The lancet. Healthy longevity
• 作者: Flood D;Seiglie JA;Dunn M;Tschida S;Theilmann M;Marcus ME;Brian G;Norov B;Mayige MT;Singh Gurung M;Aryal KK;Labadarios D;Dorobantu M;Silver BK;Bovet P;Adelin Jorgensen JM;Guwatudde D;Houehanou C;Andall-Brereton G;Quesnel-Crooks S;Sturua L;Farzadfar F;Saeedi Moghaddam S;Atun R;Vollmer S;Bärnighausen TW;Davies JI;Wexler DJ;Geldsetzer P;Rohloff P;Ramírez-Zea M;Heisler M;Manne-Goehler J
• 通讯作者: Manne-Goehler J