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Sensory Basis for Speech Motor Learning

言语运动学习的感觉基础

基本信息

批准号：
10669191
负责人：
DAVID J OSTRY
金额：
$ 54.5万
依托单位：
YALE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-08-01 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10669191
关键词：
Acoustics Affect Area Articulators Auditory Auditory area Behavioral Brain Brodmann&apos s area Cephalic Classification Data Development Experimental Models Feedback Impairment Intervention Learning Magnetic Resonance Imaging Magnetism Memory Modeling Motor Motor Cortex Movement Participant Pattern Perception Persons Play Prefrontal Cortex Process Production Rehabilitation therapy Robot Role Sensory Series Short-Term Memory Signal Transduction Somatosensory Cortex Speech Speech Perception Speech Sound Structure System Techniques Testing Time Transcranial magnetic stimulation Work behavior prediction behavioral outcome design experience experimental study face skin learning network memory consolidation motor control motor disorder motor learning neuroimaging noninvasive brain stimulation novel novel strategies robotic device sensory system somatosensory sound

项目摘要

Project Summary / Abstract This project will test a new model of speech motor learning that focuses on plasticity in sensory systems and its effects on speech movements and speech perception. The associated experiments are motivated by the results of our preliminary work and each tests a novel hypothesis related to our new model. The studies in Aim 1 use continuous theta-burst transcranial magnetic stimulation to disrupt activity in auditory and somatosensory cortex following speech motor adaptation to test the hypothesis that these sensory areas of the brain are involved in the consolidation of speech motor memory. Aim 2 tests the hypothesis that sensory working memory plays a determining role in speech motor learning. If this is the case, then if brain areas in prefrontal cortex that are associated with sensory working memory are suppressed, both learning and working memory should be impaired. In Aim 3, we test the hypothesis that speech perception is influenced by the repeated pairing of auditory and somatosensory feedback during speech motor learning. If this is the case, then manipulating somatosensory inputs in an experimental model of speech learning, which includes paired somatosensory and auditory signals, should result in subsequent changes to the perceptual classification of speech sounds. Our preliminary work on each of the three aims supports the idea that sensory plasticity plays a key role in speech motor learning and perception, and underscores the need to include these effects in models of speech motor learning. A more complete model of speech motor learning is critical if we are to understand basic mechanisms and develop novel approaches to treatment and rehabilitation for people who are affected by speech motor disorders.

项目摘要/摘要