Assessing Airway Smooth Muscle Tone in Asthma with Endobronchial Optical Coherence Tomography

使用支气管内光学相干断层扫描评估哮喘气道平滑肌张力

• 批准号: 10669149
• 负责人: David C Adams
• 金额: $ 18.9万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10669149
• 关键词: Address; Affect; Allergens; Allergic; Area; Asthma; Award; Biomechanics; Birefringence; Boston; Bronchoconstriction; Bronchoscopy; Calibration; Cardiovascular system; Chronic Obstructive Pulmonary Disease; Clinic; Clinical; Clinical Research; Clinical assessments; Control Groups; Critical Care; Data; Development; Dimensions; Disease; Doctor of Philosophy; Environment; Esophagus; Excision; Fiber; Functional Imaging; General Hospitals; Goals; Human; Hypertension; Image; Imaging Techniques; Impairment; Individual; International; Lung; Lung diseases; Massachusetts; Mathematics; Measurement; Measures; Medicine; Mentors; Methodology; Modeling; Monitor; Muscle; Muscle Contraction; Muscle Tonus; Muscle function; Nature; Optical Coherence Tomography; Optics; Organ; Physics; Physiological; Physiology; Play; Population; Positioning Attribute; Postdoctoral Fellow; Research; Research Personnel; Resistance; Resources; Role; Seminal; Smooth Muscle; Structure; System; Techniques; Technology; Tissues; Training; Translating; Translational Research; Universities; Work; associated symptom; asthmatic; body system; career; clinical translation; comparison control; computerized data processing; constriction; conventional therapy; experience; experimental study; human disease; imaging platform; in vivo; instructor; medical schools; motility disorder; muscular structure; novel; progenitor; pulmonary function; reduce symptoms; respiratory imaging; respiratory smooth muscle; signal processing; skills; structural imaging; targeted treatment; tenure track; tissue phantom; translational scientist; transmission process

Research: Asthma affects over 300 million individuals with up to an estimated 10% suffering from “treatment- resistant” asthma, for whom alternative strategies are needed. Airway smooth muscle (ASM) undergoes significant changes in asthma that increase bronchoconstriction and impair lung function. Treatments and therapies that target ASM specifically may therefore offer an alternative approach to controlling asthma, but progress is impeded by the difficulty in assessing ASM in a clinical setting. Recently we have demonstrated an imaging platform based on polarization-sensitive optical coherence tomography (PS-OCT) capable of assessing ASM distributions in vivo by exploiting the form birefringence of smooth muscle. In this proposal we are aiming to develop, validate, and implement in a pilot clinical study an extension to this technology that can be used to assess ASM function. This technology has the potential to advance not only asthma research, but research of many diseases and disorders involving smooth muscle in a number of organ systems. Candidate: David Adams, PhD is an Instructor in Medicine on the tenure track at Harvard Medical School. His long-term career goal is to become an independent translational researcher in functional imaging, focusing primarily on ASM and asthma. He has a strong background in physics, with emphasis on optics and signal processing. Since beginning postdoctoral research at Massachusetts General Hospital (MGH), he has worked on developing novel data processing techniques to maximize the utilization of data obtained with OCT imaging. The focus of this being the assessment of ASM with PS-OCT. This research will greatly benefit him in his transition to independent translational research by providing him with invaluable training in lung physiology and clinical research. Environment: Dr. Adams will train in an exceptional environment at MGH, with an abundance of resources available to help him conduct his research. His mentoring team is comprised of internationally recognized leaders in their fields: Dr. Melissa Suter, primary mentor, is a luminary in the field of translational OCT research, having been directly involved in seminal studies aimed at translating OCT imaging to the clinic. Dr. Brett Bouma, co-primary mentor, of the Wellman Center for Photomedicine at MGH is one of the key progenitors of OCT technology and translational OCT. Dr. Kenneth Lutchen, a secondary mentor, of Boston University is a pioneer in the development of experiments aimed at investigating lung physiology, and specifically ASM. Dr. Benjamin Medoff, also a secondary mentor, is chief of the Division of Pulmonary and Critical Care at MGH and a leading figure in clinical asthma research. In addition to this impressive mentoring team, Dr. Adams also has immediate access to the tremendous intellectual and collaborative opportunities available at MGH and Harvard.

研究：哮喘影响超过 3 亿人，其中估计有 10% 的人患有“治疗- 抵抗性”哮喘，需要替代策略。气道平滑肌 (ASM) 经历 哮喘的显着变化会增加支气管收缩并损害肺功能。治疗和 因此，专门针对 ASM 的疗法可能会提供另一种控制哮喘的方法，但是 临床环境中评估 ASM 的困难阻碍了进展。最近我们展示了一个 基于偏振敏感光学相干断层扫描（PS-OCT）的成像平台能够 通过利用平滑肌的双折射来评估 ASM 体内分布。在这个提案中我们 旨在开发、验证并在试点临床研究中实施该技术的扩展， 用于评估 ASM 功能。这项技术不仅有可能推动哮喘研究，而且有可能推动哮喘研究。 研究涉及多个器官系统中平滑肌的许多疾病和病症。 候选人：大卫·亚当斯（David Adams）博士是哈佛医学院的终身教授医学讲师。他的 长期职业目标是成为功能成像领域的独立转化研究员，专注于 主要针对 ASM 和哮喘。他拥有深厚的物理学背景，重点研究光学和信号 加工。自从在麻省总医院（MGH）开始博士后研究以来，他一直从事 开发新颖的数据处理技术，以最大限度地利用 OCT 成像获得的数据。 重点是使用 PS-OCT 评估 ASM。这项研究将使他在以后的工作中受益匪浅 通过为他提供肺生理学方面的宝贵培训，过渡到独立转化研究 临床研究。 环境：Adams 博士将在 MGH 优越的环境中接受训练，拥有丰富的资源 可以帮助他进行研究。他的导师团队由国际知名人士组成 各自领域的领导者：主要导师 Melissa Suter 博士是转化 OCT 领域的杰出人物 研究，直接参与旨在将 OCT 成像转化为临床的开创性研究。博士。 麻省总医院韦尔曼光医学中心的联合主要导师 Brett Bouma 是关键人物之一 OCT 技术和转化 OCT 的先驱。波士顿的二级导师 Kenneth Lutchen 博士 大学是旨在研究肺生理学的实验发展的先驱，并且 特别是 ASM。本杰明·梅多夫 (Benjamin Medoff) 博士，也是二级导师，是肺科和外科科主任 MGH 重症监护室和临床哮喘研究领域的领军人物。除了令人印象深刻的指导 团队中，亚当斯博士还可以立即获得巨大的智力和协作机会 麻省总医院 (MGH) 和哈佛大学提供。