Assessing fentanyl test strip use accuracy and fentanyl presence in the non-heroin drug supply

评估芬太尼试纸的使用准确性和非海洛因毒品供应中芬太尼的存在

• 批准号: 10668083
• 负责人: Megan Reed
• 金额: $ 24.45万
• 依托单位: THOMAS JEFFERSON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10668083
• 关键词: Acetaminophen; Address; Anticonvulsants; Benzodiazepines; Case Study; Cities; Consensus; Data; Drug usage; Drug user; Education Gap; Fentanyl; Goals; Harm Reduction; Heroin; Illicit Drugs; Interview; Knowledge; Laboratories; Law Enforcement; Length; Location; Low Prevalence; Methods; Municipalities; Outcome; Overdose; Patient Self-Report; Pennsylvania; Pharmaceutical Preparations; Philadelphia; Preparation; Prevalence; Prevention Measures; Prevention strategy; Process; Reporting; Research; Research Personnel; Sampling; Side; Stimulant; Syncope; Tablets; Technology; Testing; Time; Training; Water; Work; community organizations; community partnership; drug market; drug testing; evidence base; fentanyl contamination; fentanyl overdose; fentanyl test; fentanyl use; non-opioid analgesic; overdose prevention; overdose risk; prescription opioid; prevent; recruit; simulation; sugar; synthetic cannabinoid; test strip; tool

PROJECT ABSTRACT Fentanyl contamination of heroin and other drugs is increasingly common, leading to significant rates of unintentional fentanyl-related overdoses. Fentanyl test strips (FTS) are a low-threshold approach to mitigating fentanyl-related overdose risk among people who use drugs (PWUD). Using FTS, PWUD can dissolve a small quantity of a drug into water to test for the presence of fentanyl. PWUD report that FTS are easy to use with few logistical and environmental barriers associated with use. Moreover, emerging evidence indicates that FTS use positively impacts subsequent actions. In prior work conducted by our team, PWUD in Philadelphia reported exceptionally high rates of positive FTS results on non-heroin drugs, far higher than rates seen in other locations. Possible explanations for these discordant results include saturation of the Philadelphia illicit drug market with fentanyl, incorrect use of FTS, incorrect interpretation of FTS, or a combination of the three. Despite increasing distribution of FTS, no studies to date have explored the accuracy of FTS use by PWUD. In addition, while the prevalence of fentanyl in the heroin supply has been widely documented, it is currently unknown to what extent fentanyl is present in non-heroin drug markets. Based upon the recent findings in Philadelphia reporting alarmingly high rates of FTS positivity with non-heroin drugs and these gaps in current knowledge regarding both FTS use and contamination of the non-heroin drug supply, there is an urgent need to assess the accuracy of FTS use among PWUD and the extent fentanyl is present in the Philadelphia non- heroin drug supply. The long-term goal of this work is to advance overdose prevention measures using FTS and other drug-checking technology in drug markets around the U.S. The overall objective of this proposal is to leverage established municipal and community partnerships in Philadelphia and the use of advanced drug- checking technology to explicate gaps identified between previously detected levels of fentanyl in the drug supply and self-reported results from FTS use among PWUD in Philadelphia. Our objective will be achieved with two specific aims: (1) Determine user process of use and interpretation of FTS and (2) Estimate the true presence of fentanyl in the non-heroin drug supply in Philadelphia, PA. This study will have significant impact by addressing knowledge gaps regarding utility of FTS as a harm reduction strategy and providing actionable evidence regarding the extent of fentanyl presence in non-heroin drugs. We anticipate three outcomes from aims: (1) the identification of educational gaps in the proper use of FTS and interpretation of their results among PWUD, (2) point-in-time data for fentanyl contamination of non-heroin illicit drugs in Philadelphia, and (3) informing ongoing national campaigns to educate PWUD about FTS and overdose prevention strategies. Study findings will enhance evidence-based overdose prevention efforts targeted at supply-side fentanyl contamination and real-world FTS use practices by PWUD.

项目摘要 芬太尼对海洛因和其他毒品的污染越来越普遍， 与芬太尼有关的意外过量芬太尼测试条（FTS）是一种低门槛的方法，以减轻 芬太尼相关的过量使用药物的人（PWUD）的风险。使用FTS，PWUD可以溶解小的 将一定量的药物放入水中以测试芬太尼的存在。PWUD报告称，FTS易于使用， 与使用相关的物流和环境障碍很少。此外，新的证据表明，FTS 使用会对后续行动产生积极影响。在我们的团队之前进行的工作中，费城的PWUD 报告说，非海洛因药物的阳性FTS结果率异常高，远远高于1999年的比率。 其他地点。对这些不一致结果的可能解释包括费城非法移民的饱和 芬太尼的药物市场，FTS的不正确使用，FTS的不正确解释，或三者的组合。 尽管FTS的分布越来越多，但迄今为止还没有研究探讨PWUD使用FTS的准确性。在 此外，虽然广泛记录了芬太尼在海洛因供应中的流行情况，但目前 芬太尼在非海洛因毒品市场的存在程度尚不清楚。根据最近的调查结果， 费城报告的非海洛因药物的FTS阳性率高得惊人，目前的这些差距 关于FTS使用和非海洛因药物供应污染的知识，迫切需要 评估FTS在PWUD中使用的准确性以及芬太尼在费城非 海洛因毒品供应这项工作的长期目标是使用FTS推进过量预防措施 和其他药物检查技术在美国各地的药物市场，这项建议的总体目标是， 利用费城建立的市政和社区伙伴关系以及先进药物的使用- 检查技术，以解释先前在药物中检测到的芬太尼水平之间的差距 供应和自我报告的结果，从FTS使用之间的PWUD在费城。我们的目标一定会达到 有两个具体目标：（1）确定用户使用和解释FTS的过程;（2）估计真实的 在宾夕法尼亚州费城的非海洛因药物供应中存在芬太尼。这项研究将产生重大影响 通过解决关于FTS作为减少危害战略的效用的知识差距， 关于芬太尼在非海洛因药物中存在程度的证据。我们预计， 目的：（1）确定正确使用FTS的教育差距，并解释其结果 在PWUD中，（2）费城非海洛因非法药物芬太尼污染的时间点数据，以及 (3)为正在进行的全国运动提供信息，以教育PWUD了解FTS和过量预防战略。 研究结果将加强针对供应方芬太尼的基于证据的过量预防工作 污染和真实世界的FTS使用实践。