Wake Forest Clinical and Translational Science Award

维克森林临床和转化科学奖

• 批准号: 10667486
• 负责人: Jamy D Ard
• 金额: $ 392.8万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-13 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10667486
• 关键词: Academic support; Academy; Acceleration; Achievement; Address; Appalachian Region; Area; Biological Models; Caring; Clinical; Clinical Research; Clinical Sciences; Clinical Trials; Clinical and Translational Science Awards; Collaborations; Communities; Community Physician; Contracts; Data; E-learning; Education; Environment; Equity; Fostering; Funding; Goals; Health; Health system; Healthcare; Healthcare Systems; Incentives; Informatics; Institutional Review Boards; Integrated Health Care Systems; Interdisciplinary Study; Investments; Knowledge; Laboratories; Leadership; Learning; Link; Longevity; Mentors; Methods; Mission; Modeling; Multicenter Trials; North Carolina; Participant; Population; Positioning Attribute; Process; Program Development; Reproducibility; Research; Research Infrastructure; Research Personnel; Research Support; Resources; Role; Safety; Scholars Program; Scholarship; Science; Scientific Advances and Accomplishments; Scientist; Special Population; Speed; Structure; System; TNFSF15 gene; Testing; Textiles; Training; Training Programs; Translational Research; Translations; Vision; Workforce Development; biomedical informatics; catalyst; community engagement; data sharing; design; early-career faculty; education research; education resources; empowerment; experience; forest; implementation science; improved; informatics infrastructure; innovation; member; next generation; nonhuman primate; population health; pre-clinical; precision medicine; programs; skills; success; tool; translational pipeline; translational progress; workforce needs

Contact PD/PI: MCCLAIN, DONALD A. Summary: Overall When the Wake Forest (WF) Clinical and Translational Science Institute (CTSI) joined the CTSA consortium in August 2015, our goal was to use our resources to catalyze WF’s transformation into an exemplary Learning Health System in which “science, informatics, incentives, and culture are aligned for continuous improvement and innovation, with best practices seamlessly embedded in the delivery process and new knowledge captured as an integral by-product of the delivery experience.” We seek to extend this framework by integrating traditional academic goals of T0 – T4 discovery, translation, and scholarship to form a new vision—the Academic Learning Health System (aLHS). In our initial 3 years of funding, we have progressed towards our goal, establishing an integrated research governance model, with the CTSI at its core, to realize efficiencies and address roadblocks that hamper translational progress. We established Translational Catalysts to link the academic and clinical enterprises and designed training programs to develop the skills our workforce needs to make the aLHS a reality. We developed foundational informatics infrastructures essential to learning and growing, engaged communities and stakeholders to integrate diverse perspectives into the fabric of our aLHS, and created a milieu for nurturing innovative translational methods. We became a valued member of the CTSA national network, actively collaborating with 20 CTSA hubs, and shared our world-class nonhuman primate models with the consortium. With these successes, we turn to the next 5 years with strong assets in leadership, structure, scholarship, and culture that uniquely position us to realize the aLHS ideal. We will fully integrate our new Translational Catalysts – biomedical informatics, implementation science, precision medicine, healthcare innovation, and clinical trials – and use them, along with incentives for academic engagement, to mobilize our growing clinical network. We will develop, implement, and broadly disseminate improved methods and processes that will increase the efficiency, safety, and reproducibility of preclinical and clinical science. We will partner with our community to integrate special populations, and support health research across the lifespan. We will train our workforce for new roles, especially in team environments, with new training programs (e.g., TL1 aLHS Scholars Program, the Learning TREE online educational platform for individualized learning, Research-in-Action) and broaden our highly successful KL2 training for early-career faculty. We will serve as a hub for biomedical informatics, accelerating progress by enhancing existing resources, promoting collaboration and data sharing, and building new capacity. We will remain committed to inclusiveness, mutual respect, and multiple perspectives to act as a catalyst for change and healthy equity. We will further extend the reach of the aLHS into the communities served by our expanding health system and will broaden our collaborations with other CTSA hubs to share best practices and export the aLHS model – all guided by our ultimate goal of improving the health of our region and nation. Page 243 Project Summary/Abstract Contact PD/PI: MCCLAIN, DONALD A. Narrative: Overall The Wake Forest Clinical and Translational Science Institute seeks to become the model of an integrated Academic Learning Health System in which we develop, implement, offer tailored training tools, and broadly disseminate improved methods and processes to increase the efficiency, safety, and reproducibility of preclinical and clinical science. We will build on our achievements to fully integrate our new Translational Catalysts – biomedical informatics, implementation science, precision medicine, healthcare innovation and clinical trials – and use them to develop and test initiatives, deploying research findings across our growing clinical network. We will remain committed to training the next generation of scientists and leaders and will partner with our community and CTSA hubs to integrate special populations and support research across the lifespan to extend the benefits of our progress to the widest possible audience. Page 244

联系PD/PI：McClain，Donald A. 摘要：总体 当维克森林(WF)临床和翻译科学研究所(CTSI)于年加入CTSA联盟时 2015年8月，我们的目标是利用我们的资源催化WF转变为模范学习 健康体系，在这个体系中，科学、信息、激励和文化相结合，不断改进 和创新，在交付过程中无缝嵌入最佳实践并获取新知识 作为交付体验的一个不可或缺的副产品。我们寻求通过集成传统的 T0-T4发现、翻译和学术形成新视野的学术目标--学术学习 卫生系统(ALHS)。在我们最初3年的资助中，我们朝着我们的目标前进了一步，建立了 以CTSI为核心的综合研究治理模式，以实现效率并解决障碍 这阻碍了翻译的进展。我们建立了翻译催化剂，将学术和临床联系起来 并设计了培训计划，以发展我们的劳动力所需的技能，使aLHS成为现实。 我们开发了基本的信息基础设施，对学习和发展参与式社区至关重要 和利益相关者将不同的视角整合到我们的aLHS结构中，并创造了一个培育环境 创新翻译方法。我们积极地成为CTSA国家网络的宝贵成员 与20个CTSA中心合作，并与该联盟分享了我们世界级的非人类灵长类动物模型。 有了这些成功，我们将转向未来5年，拥有强大的领导力、结构、学术和 独特的文化定位，使我们能够实现aLHS理想。我们将全面整合我们的新型转化催化剂 --生物医学信息学、实施科学、精准医学、医疗创新、临床试验-- 并利用它们，以及对学术投入的激励，来动员我们日益增长的临床网络。我们会 制定、实施和广泛传播改进的方法和流程，以提高效率， 临床前和临床科学的安全性和重复性。我们将与我们的社区合作，整合 特殊人群，并支持整个生命周期的健康研究。我们将培训我们的员工适应新的角色， 特别是在团队环境中，通过新的培训方案(例如，TL1 aLHS学者方案、学习 用于个性化学习、行动研究的在线教育平台)并拓宽我们的高度 为早期职业教师提供成功的KL2培训。我们将成为生物医学信息学的枢纽，加速 通过加强现有资源、促进协作和数据共享以及建设新的能力来取得进展。 我们将继续致力于包容、相互尊重和多视角，以推动 变革和健康的公平。我们会进一步将辅助生活服务的服务范围扩展至我们的 扩大卫生系统，并将扩大我们与其他CTSA中心的合作，以分享最佳做法和 出口aLHS模式-所有这些都是以我们改善我们地区和国家健康的最终目标为指导的。 第243页 项目摘要/摘要 联系PD/PI：McClain，Donald A. 叙事：整体 维克森林临床和翻译科学研究所寻求成为综合 学术学习健康系统，我们在其中开发、实施、提供定制的培训工具，以及广泛的 传播改进的方法和流程，以提高临床前研究的效率、安全性和可重复性 和临床科学。我们将在已有成果的基础上，全面整合我们的新型翻译催化剂- 生物医学信息学、实施科学、精准医学、医疗创新和临床试验-- 并使用它们来开发和测试倡议，在我们不断增长的临床网络中部署研究成果。 我们将继续致力于培养下一代科学家和领导者，并将与我们的 社区和CTSA中心，以整合特殊人群并支持跨生命周期的研究以延长 让尽可能多的观众了解我们的进步带来的好处。 第244页

项目成果

Incorporating Volunteering Into Treatment for Depression Among Adolescents: Developmental and Clinical Considerations.

• DOI: 10.3389/fpsyg.2021.642910
• 发表时间: 2021
• 期刊: Frontiers in psychology
• 影响因子: 3.8
• 作者: Ballard PJ;Daniel SS;Anderson G;Nicolotti L;Caballero Quinones E;Lee M;Koehler AN
• 通讯作者: Koehler AN

In the Pursuit of Privacy: The Promises and Predicaments of Federated Learning in Healthcare.

• DOI: 10.3389/frai.2021.746497
• 发表时间: 2021
• 期刊: Frontiers in artificial intelligence
• 影响因子: 4
• 作者: Topaloglu MY;Morrell EM;Rajendran S;Topaloglu U
• 通讯作者: Topaloglu U

The development and validation of the laryngopharyngeal measure of perceived sensation.

感知感觉的喉咽测量的开发和验证。

• DOI: 10.1002/lary.28348
• 发表时间: 2020
• 期刊: The Laryngoscope
• 作者: Melancon,CClaire;Russell,GregoryB;Ruckart,Kathryn;Persia,Sarah;Peterson,Margarita;CarterWrightJr,,S;Madden,LyndsayL
• 通讯作者: Madden,LyndsayL

The Generalizability of a Medication Administration Discrepancy Detection System: Quantitative Comparative Analysis.

药物给药差异检测系统的普遍性：定量比较分析。

• DOI: 10.2196/22031
• 发表时间: 2020-12-02
• 期刊: JMIR medical informatics
• 影响因子: 3.2
• 作者: Kirkendall E;Huth H;Rauenbuehler B;Moses A;Melton K;Ni Y
• 通讯作者: Ni Y

Implementation of a Community Walking Program (Walk On!) for Functionally-Limited Older Adults.

实施社区步行计划（步行！），以实施功能有限的老年人。

• DOI: 10.14283/jfa.2020.12
• 发表时间: 2020
• 期刊: The Journal of frailty & aging