Center for Studies of Host Response to Cancer Therapy

宿主对癌症治疗的反应研究中心

• 批准号: 10667643
• 负责人: Marjan Boerma
• 金额: $ 228万
• 依托单位: UNIV OF ARKANSAS FOR MED SCIS
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-06-24 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10667643
• 关键词: Address; Adverse effects; Advisory Committees; Affect; Aftercare; Animals; Applications Grants; Arkansas; Award; Biological; Biomedical Research; Cancer Detection; Cancer Patient; Cancer Survivor; Cancer Survivorship; Centers of Research Excellence; Chemotherapy and/or radiation; Chronic; Clinical; Collaborations; Dedications; Development; Development Plans; Discipline; Dose Limiting; Early Diagnosis; Ensure; Environment; Extramural Activities; Faculty; Fee-for-Service Plans; Funding; Funding Agency; Goals; Immune response; Immune system; Individual; Institution; Interdisciplinary Study; Life; Malignant Neoplasms; Medical; Mentors; Methods; Oncology; Pediatric Hospitals; Phase; Pilot Projects; Predisposition; Preparation; Process; Productivity; Qualifying; Quality of life; Radiation; Radiation therapy; Research; Research Infrastructure; Research Institute; Research Personnel; Research Project Grants; Research Support; Resources; Role; Science; Scientist; Secure; Services; Structure; Teacher Professional Development; Therapeutic; Tissues; Toxicology; Translational Research; Treatment Efficacy; Treatment outcome; Treatment-Related Cancer; Treatment-related toxicity; United States National Institutes of Health; Universities; anticancer treatment; base; cancer therapy; career; chemotherapy; comparative; disability; effective intervention; improved; interest; multidisciplinary; novel strategies; prevent; programs; psychosocial; recruit; response; side effect; success; synergism; therapy adverse effect; translational approach; tumor

PROJECT SUMMARY/ABSTRACT The objectives of the Center for Studies of Host Response to Cancer Therapy are to (1) form a self-sustaining multidisciplinary research center within the University of Arkansas for Medical Sciences (UAMS) to increase the understanding of mechanisms of side effects of cancer therapy, identify methods for early detection, and develop strategies to prevent or treat such side effects and (2) help junior investigators with research programs in this common theme establish themselves as independent scientists. Achieving these goals will create a vibrant, multidisciplinary yet synergistic research environment. To our knowledge, few research centers focus on cancer survivorship, and none take the paradigm-shifting approach of proactively addressing treatment-related toxicities to improve overall cancer treatment outcomes. Specifically, this Center will provide an environment for young investigators to succeed as independent scientists (Aim 1); strengthen the overall research infrastructure at UAMS and the Winthrop P. Rockefeller Cancer Institute (Aim 2); and ensure that the Center becomes self- sustaining (Aim 3). All 6 project leaders recruited to the Center in Phase 1 have built well-funded, productive research programs and close collaborations with each other and several of the pilot project grantees. In preparation for Phase 2, we have recruited 4 promising new/early-stage independent investigators. During Phase 1, the Center focused heavily on radiation therapy. To increase the impact and scope of the Center while retaining its overall theme, project leaders recruited for Phase 2 have a research focus on both radiation and chemotherapy. To increase the likelihood that project leaders will successfully secure independent extramural research funding, individualized mentoring and faculty-development plans will be implemented, and support from an administrative core and 2 research service cores will be integral. To replace project leaders who achieve independence and graduate from COBRE support, a pipeline of new project leaders is ensured through institutional support for recruiting junior faculty combined with a structured pilot project program. Strengthening our interactions with the 5 other COBRE Centers and additional NIH-supported programs that enhance biomedical research on the UAMS and affiliated campuses will also contribute to establishing the Center as a self-sustaining research program that is well-integrated in the institution. The Center's progress will be guided by highly qualified External and Internal Advisory Committees. Strong institutional support combined with active interest from funding agencies in improving uncomplicated cancer cure rates and the quality of life of cancer survivors ensures a high likelihood of success for the Center for Studies of Host Response to Cancer Therapy.

项目摘要/摘要 癌症治疗宿主反应研究中心的目标是：(1)形成一个自我维持的 阿肯色大学医学科学(UAMS)内的多学科研究中心，以增加 了解癌症治疗副作用的机制，找出早期发现的方法，并开发 预防或治疗这种副作用的策略以及(2)帮助初级调查人员开展这方面的研究计划 共同的主题将自己确立为独立的科学家。实现这些目标将创造一个充满活力的 多学科但协同的研究环境。据我们所知，很少有研究中心关注癌症 存活，没有人采取改变模式的方法，积极应对与治疗相关的毒性 以改善整体癌症治疗结果。具体来说，这个中心将为年轻人提供一个环境 调查人员作为独立科学家取得成功(目标1)；加强总体研究基础设施 UAMS和温斯罗普·P·洛克菲勒癌症研究所(AIM 2)；并确保该中心成为自我 持续(目标3)。在第一阶段招募到该中心的所有6个项目负责人都建立了资金充足、生产效率高的 研究计划和与彼此以及几个试点项目受赠者之间的密切合作。在……里面 为了准备第二阶段，我们已经招募了4名有前途的新的/早期独立调查人员。在阶段中 1、该中心主要关注放射治疗。扩大中心的影响和范围，同时 在保持总体主题的基础上，为第二阶段招募的项目负责人将研究重点放在辐射和 化疗。增加项目负责人成功获得独立外部人员的可能性 将实施研究资金、个性化指导和教师发展计划，并从 1个行政核心和2个研究服务核心将是不可或缺的。以取代实现以下目标的项目负责人 独立并从Cobre Support毕业，通过以下方式确保新项目负责人的渠道 为招聘初级教员提供的机构支持与结构化的试点项目计划相结合。强化 我们与其他5个Cobre中心的互动以及NIH支持的其他计划 对UAMS及其附属校区的生物医学研究也将有助于将该中心建立为 自给自足的研究项目，与机构紧密结合。该中心的进展将得到指导 由高素质的外部和内部咨询委员会提供。强有力的制度支持与积极的行动相结合 资助机构对提高简单癌症治愈率和癌症生活质量的兴趣 幸存者确保癌症治疗宿主反应研究中心成功的可能性很高。

项目成果

Cognitive impairment resulting from treatment with docetaxel, doxorubicin, and cyclophosphamide.

多西他赛，阿霉素和环磷酰胺治疗导致的认知障碍。

• DOI: 10.1016/j.brainres.2021.147397
• 发表时间: 2021-06-01
• 期刊: Brain research
• 影响因子: 2.9

Lobelane analogues containing 4-hydroxy and 4-(2-fluoroethoxy) aromatic substituents: Potent and selective inhibitors of [(3)H]dopamine uptake at the vesicular monoamine transporter-2.

• DOI: 10.1016/j.bmcl.2016.03.119
• 发表时间: 2016-05-15
• 期刊: Bioorganic & medicinal chemistry letters
• 影响因子: 2.7
• 作者: Joolakanti SR;Nickell JR;Janganati V;Zheng G;Dwoskin LP;Crooks PA
• 通讯作者: Crooks PA

Fractionated exposure to low doses of ionizing radiation results in accumulation of DNA damage in mouse spleen tissue and activation of apoptosis in a p53/Atm-independent manner.

• DOI: 10.1080/09553002.2017.1231943
• 发表时间: 2017-03
• 期刊: International journal of radiation biology
• 影响因子: 2.6
• 作者: Koturbash I;Merrifield M;Kovalchuk O
• 通讯作者: Kovalchuk O

Ionizing Radiation Activates Mitochondrial Function in Osteoclasts and Causes Bone Loss in Young Adult Male Mice.

• DOI: 10.3390/ijms23020675
• 发表时间: 2022-01-08
• 期刊: International journal of molecular sciences
• 影响因子: 5.6
• 作者: Richardson KK;Ling W;Krager K;Fu Q;Byrum SD;Pathak R;Aykin-Burns N;Kim HN
• 通讯作者: Kim HN

Epigenetic Control of Cdkn2a.Arf Protects Tumor-Infiltrating Lymphocytes from Metabolic Exhaustion.

• DOI: 10.1158/0008-5472.can-20-0524
• 发表时间: 2020-11-01
• 期刊: Cancer research
• 影响因子: 11.2
• 作者: Koss B;Shields BD;Taylor EM;Storey AJ;Byrum SD;Gies AJ;Washam CL;Choudhury SR;Hyun Ahn J;Uryu H;Williams JB;Krager KJ;Chiang TC;Mackintosh SG;Edmondson RD;Aykin-Burns N;Gajewski TF;Wang GG;Tackett AJ
• 通讯作者: Tackett AJ