A Micro-Randomized Trial to Optimize Just-in-Time Adaptive Intervention for Binge Eating & Weight-related Behaviors

优化暴饮暴食即时适应性干预的微随机试验

• 批准号: 10670994
• 负责人: Andrea Kass Graham
• 金额: $ 68.96万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10670994
• 关键词: Address; Adult; Age; Algorithms; Behavior; Behavior Disorders; Behavioral; Behavioral Mechanisms; Binge Eating; Body Weight Changes; Body Weight decreased; Caring; Characteristics; Clinical; Data; Development; Diet; Drops; Eating; Eating Disorders; Ethnic Origin; Evidence based treatment; Failure; Food; Future; Goals; Health Care Costs; Health Services Accessibility; Individual; Infrastructure; Intervention; Learning; Metabolic syndrome; Methodology; Mission; Modeling; Moods; Morbidity - disease rate; Motivation; National Institute of Diabetes and Digestive and Kidney Diseases; Obesity; Outcome; Persons; Physical activity; Process; Race; Randomized; Recommendation; Recurrence; Risk; Role; Shapes; Specific qualifier value; Testing; Theoretical model; Time; Treatment outcome; United States National Institutes of Health; Weight; Weight maintenance regimen; Work; adaptive intervention; adult obesity; behavior change; behavior influence; behavioral economics; comorbidity; design; digital; digital delivery; digital intervention; evidence base; excessive weight gain; experience; follow-up; handheld mobile device; improved; improved outcome; interest; mortality; multi-component intervention; negative affect; personalized intervention; personalized medicine; post intervention; psychologic; randomized trial; self help; sex; targeted delivery; therapy design

Two in five U.S. adults have obesity, and up to 30% of treatment-seeking adults with obesity engage in binge eating, an eating disorder behavior characterized by eating a large amount of food and experiencing a loss of control while eating. First-line interventions are face-to-face treatments, but current approaches commonly fail to address both conditions and cannot reach all people in need. To fill this gap, we designed FoodSteps, the first intervention for both obesity and binge eating, delivered by mobile device to increase scalability. We integrated key mechanisms of behavioral and psychological treatments to provide a personalized medicine approach that intervenes on five evidence-based treatment targets. Each week, users select a target and create a plan for how they will practice that target to change their behavior. Our pilot data show FoodSteps is engaging with high rates of completion and compliance, and intervening on the targets improves weekly binge eating and weight on average, but rates are suboptimal. Our data indicate more precise intervention is needed, but three challenges impede achieving this goal. It is unknown 1) which evidence-based targets are most impactful for which people; and 2) in what sequence; as well as 3) how best to deliver targets to propel users to change their behavior. We will resolve these challenges with a micro-randomized trial, the methodologically ideal design because it uses repeated randomization to inform how to precisely intervene based on individual needs. Adults with obesity and recurrent binge eating will receive FoodSteps for 16 weeks. Each week, 1 of the 5 targets will be randomly delivered to each user, to identify which targets work for whom (Aim 1) and in what sequence (Aim 2). Weekly targets also will be randomly delivered either as a recommended target users can select or as an assigned target, to identify how to deliver targets to propel behavior change (Aim 3). We will assess time-varying user characteristics as moderators to inform the development of personalized algorithms to tailor interventions to user needs over time. Our outcomes of interest are weekly changes in binge eating, since it is a behavior that puts overall weight loss at risk, and change in weight long-term (Aim 4). Our data will provide the infrastructure to build a just-in-time adaptive intervention (JITAI) capable of delivering highly personalized intervention for binge eating and weight-related behaviors at a critical point in the behavior change process; we will test the JITAI in a future trial. This trial furthers NIH and NIDDK’s mission to advance treatment via more precise approaches by specifying which treatment targets drive behavior change, led by a team expert in optimizing digital interventions, intervening on obesity and binge eating, and conducting micro- randomized trials. Results have implications beyond FoodSteps given the role of these targets and processes for behavior change broadly, and will propel personalized medicine by informing sophisticated models for achieving the ultimate goal of personalizing the delivery of digital and non-digital interventions.

五分之二的美国成年人患有肥胖症，而在寻求治疗的肥胖成年人中，有多达30%的人暴饮暴食