Core D Functional Vision Module

Core D 功能视觉模块

• 批准号: 10670899
• 负责人: Brian D Perkins
• 金额: $ 5.02万
• 依托单位: CLEVELAND CLINIC LERNER COM-CWRU
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10670899
• 关键词: Animal Experiments; Animal Model; Behavior; Behavioral Assay; Biological Assay; Brain; Cells; Center Core Grants; Clinic; Collaborations; Core Facility; Data; Data Set; Detection; Development; Disease; Electrophysiology (science); Electroretinography; Elements; Eye; Eye diseases; Faculty; Fostering; Funding; Grant; Human; Light; Measurement; Measures; Methods; Mus; Ophthalmology; Patients; Pattern; Photoreceptors; Physiological; Productivity; Reflex action; Research; Research Personnel; Research Support; Resources; Scientist; Services; Signal Transduction; Stimulus; Talents; Technology; Testing; Tissues; Training; Treatment Efficacy; Vision; Vision research; Visual; Visual System; Visual evoked cortical potential; Zebrafish; behavior test; behavioral response; equipment training; improved; insight; instrumentation; programs; recruit; research faculty

Abstract Functional Vision Core The Functional Vision Core will provide the technologies required to interrogate visual function in experimental animals to the investigators involved in this P30 Cole Eye Vision Research Core. The Functional Vision Core will provide state of the art assessment of visual function in mice and zebrafish. This will include visual electrophysiological assays such as the electroretinogram (ERG), pattern ERG, the visual evoked potential (VEP), and visual behavior assays such as the optokinetic reflex (OKR), optomotor reflex (OMR) and threshold measurement. Collectively, these assays interrogate visual function from light detection in the photoreceptors to signal integration and interpretation within the brain. This Core will support NEI R01-funded investigators, help investigators obtain data for additional NEI R01 grant submissions, foster collaborative interactions between R01-funded investigators, attract investigators from other departments to research on the visual system and be a valuable departmental resource in attracting additional vision scientists to our program as we expand our research faculty.

摘要