Core D Functional Vision Module

Core D 功能视觉模块

• 批准号: 10273080
• 负责人: Brian D Perkins
• 金额: $ 5.02万
• 依托单位: CLEVELAND CLINIC LERNER COM-CWRU
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10273080
• 关键词: Animal Model; Animals; Behavior; Behavioral Assay; Biological Assay; Brain; Cells; Center Core Grants; Clinic; Collaborations; Core Facility; Data; Data Set; Detection; Development; Disease; Electrophysiology (science); Electroretinography; Elements; Eye; Eye diseases; Faculty; Fostering; Funding; Grant; Human; Institutes; Light; Measurement; Measures; Methods; Mus; Ophthalmology; Patients; Pattern; Photoreceptors; Physiological; Productivity; Reflex action; Research; Research Personnel; Research Support; Resources; Scientist; Services; Signal Transduction; Stimulus; Talents; Technology; Testing; Tissues; Training; Treatment Efficacy; Vision; Vision research; Visual; Visual evoked cortical potential; Visual system structure; Zebrafish; behavior test; behavioral response; equipment training; faculty research; improved; insight; instrumentation; programs; ranpirnase; recruit

Abstract Functional Vision Core The Functional Vision Core will provide the technologies required to interrogate visual function in experimental animals to the investigators involved in this P30 Cole Eye Vision Research Core. The Functional Vision Core will provide state of the art assessment of visual function in mice and zebrafish. This will include visual electrophysiological assays such as the electroretinogram (ERG), pattern ERG, the visual evoked potential (VEP), and visual behavior assays such as the optokinetic reflex (OKR), optomotor reflex (OMR) and threshold measurement. Collectively, these assays interrogate visual function from light detection in the photoreceptors to signal integration and interpretation within the brain. This Core will support NEI R01-funded investigators, help investigators obtain data for additional NEI R01 grant submissions, foster collaborative interactions between R01-funded investigators, attract investigators from other departments to research on the visual system and be a valuable departmental resource in attracting additional vision scientists to our program as we expand our research faculty.

摘要 功能愿景核心 功能性视觉核心将提供询问实验动物视觉功能所需的技术 P30科尔视力研究中心的调查人员。功能视觉核心将提供状态 在小鼠和斑马鱼中视觉功能的现有技术评估。这将包括视觉电生理测定， 如视网膜电图（ERG）、图形ERG、视觉诱发电位（VEP）和视觉行为测定，如 视动反射（OKR）、视动反射（OMR）和阈值测量。总的来说，这些测定询问 从光感受器中的光检测到大脑内的信号整合和解释的视觉功能。这 核心将支持NEI R01资助的研究者，帮助研究者获得额外NEI R01资助的数据 提交，促进R01资助的研究者之间的合作互动，吸引来自其他研究者的研究者， 部门研究视觉系统，并成为吸引更多视觉的宝贵部门资源 科学家加入我们的计划，因为我们扩大了我们的研究人员。