Addressing the wireless power problem: A low-power hybrid radio for neuroscience experiments

解决无线电源问题：用于神经科学实验的低功耗混合无线电

• 批准号: 10697023
• 负责人: Rebecca Jeanne Gerth
• 金额: $ 56.73万
• 依托单位: SPIKE NEURO LLC
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10697023
• 关键词: Achievement; Address; Animal Experimentation; Animal Model; Animals; Architecture; Behavior; Bite; Clinical; Clinical Research; Communities; Complex; Computer software; Contracts; Data; Data Element; Dedications; Development; Devices; Disadvantaged; Dropout; Drops; Electric Stimulation; Electronics; Electrophysiology (science); Ensure; Future; Head; Hybrids; Industry Standard; Marketing; Modeling; Morphologic artifacts; Motion; Mus; Neurologic; Neurosciences; Neurosciences Research; Noise; Output; Performance; Phase; Physiologic pulse; Polychlorinated Biphenyls; Production; Radio; Rattus; Renaissance; Research; Research Design; Research Personnel; Rest; Rodent; Sales; Series; Signal Transduction; Small Business Technology Transfer Research; Social Interaction; Stress; System; Technology; Testing; Time; Universities; Update; Validation; Weight; Wireless Technology; Work; analog; awake; base; battery life; battery size; clinical development; clinical translation; commercialization; commercialization readiness; data acquisition; data exchange; design; digital; experimental study; flexibility; in vivo; innovation; light weight; manufacture; meter; mouse model; nervous system disorder; neural; neurotransmission; nonhuman primate; novel; power consumption; prototype; radio frequency; research and development; research study; sensorimotor system; success; tool; transmission process; wireless; wireless transmission

Project Summary Closed-loop stimulation is key to the study and treatment of neurological disorders. However, largely due to current wireless power demands, stimulation systems are restricted to wired connections, which impact natural behavior, induce motion artifacts, and limit complexity of study design. While a few wireless recording- only systems have been developed, the power demands of these devices prohibit the addition of wireless electrical stimulation while staying within size and weight limitations for smaller animal models. These limitations are roadblocks to the next phase of neuroscience research and clinical development. In this Phase I, 1.5 year, STTR project, Spike Neuro is partnering with Duke University to develop a novel low power hybrid backscatter radio frequency system to enable the commercialization of a series of wireless recording and electrical stimulation headstages for small and large animal electrophysiology research. This innovative wireless technology shifts the high-power demand features out of the headworn components to the base station, significantly reducing battery size and weight enabling the addition of the electrical stimulation components and allowing for more flexibility in recording only experiments. This development work will result in two headstage options for small animals with 5 and 16 channels of recording and 2 channels of electrical stimulation and two slightly larger systems for 32 and 64 channels of recording with 8 channels of electrical stimulation. Aim 1 focuses on the development of the 5 and 16 channel systems and the electrical stimulation integration. Aim 2 will build upon the efforts in Aim 1 to expand the system to up to 64 channels with 8 channels of electrical stimulation. Both aims will also include hardware and software integration with the Spike Neuro data acquisition system. Aim 3 will conclude with benchtop and in vivo validation of our system to demonstrate successfully achieving key features needed for a commercial wireless recording and stimulation headstage. This proposal brings together a strong team of experts in wireless technology, electrophysiology, and commercialization to develop a wireless system that meets the growing needs of the neuroscience community. The Phase I work will result in a multiple headstage options ready for commercialization while informing continued Phase II development. In our future work, we will continue to scale our system to increase channel count and reduce the latency of the closed-loop electrical stimulation.

项目摘要 闭合环刺激是研究和治疗神经系统疾病的关键。然而，很大程度上是因为 目前的无线电力需求，刺激系统仅限于有线连接，这影响了 自然行为，诱发运动伪影，限制研究设计的复杂性。而一些无线记录- 只有系统已经开发出来，这些设备的电力需求禁止添加无线 电刺激，同时保持在较小动物模型的大小和体重限制内。这些 局限性是下一阶段神经科学研究和临床开发的障碍。 在这个为期一年半的第一阶段STTR项目中，Spike Neuro正与杜克大学合作开发一种新的Low 功率混合后向散射射频系统使一系列无线能够商业化 记录和电刺激大小动物电生理学研究的前台。这 创新的无线技术将高功率需求功能从头戴式组件转移到 基站，显著减小电池尺寸和重量，从而能够增加电刺激 组件，并允许更多的灵活性，只记录实验。 这项开发工作将为小动物提供两个主台选项，分别有5个和16个声道录制 2个电刺激通道和两个稍大的系统，用于32和通道的记录 8路电刺激。目标1侧重于5频道和16频道系统的发展和 电刺激集成。目标2将在目标1努力的基础上，将该系统扩展到 通道电刺激8个通道。这两个目标还将包括硬件和软件集成 使用Spike Neuro数据采集系统。目标3将以台式和活体验证我们的 演示成功实现商业无线记录所需的关键功能的系统 刺激前台。 这项建议汇集了无线技术、电生理学和 商业化，以开发满足神经科学界日益增长的需求的无线系统。 第一阶段工作将产生多个前期选择，为商业化做好准备，同时通知 第二阶段继续发展。在未来的工作中，我们将继续扩大我们的系统，以增加渠道 计算并减少闭环电刺激的潜伏期。