Addressing the wireless power problem: A low-power hybrid radio for neuroscience experiments

项目摘要 闭环刺激是神经系统疾病研究和治疗的关键。然而，主要由于 当前的无线电力需求，刺激系统被限制为有线连接，这影响了 自然行为，诱导运动伪影，并限制研究设计的复杂性。一些无线录音- 只有系统已经开发，这些设备的电力需求禁止增加无线 电刺激，同时保持在较小动物模型的尺寸和重量限制内。这些 局限性是神经科学研究和临床开发下一阶段的障碍。 在这个第一阶段，1.5年，STTR项目，斯派克神经是与杜克大学合作，开发一种新的低 功率混合反向散射射频系统，使一系列的无线商业化 用于小型和大型动物电生理学研究的记录和电刺激头台。这 创新的无线技术将高功率需求功能从头戴式组件转移到 基站，显著减小电池尺寸和重量，从而能够增加电刺激 组件，并允许更灵活地记录实验。 这项开发工作将为小动物提供两种头台选择，分别具有5和16个录音通道 和2个电刺激通道和两个稍大的系统，用于32和64个记录通道， 8个电刺激通道。目标1的重点是发展5和16声道系统， 电刺激整合。目标2将在目标1的基础上，将系统扩展到64个 8个电刺激通道。这两个目标还将包括硬件和软件集成 Spike Neuro数据采集系统目标3将结束与实验室和体内验证我们的 演示成功实现商业无线记录所需关键功能的系统， 刺激头台。 该提案汇集了无线技术、电生理学和 该公司的目标是开发一种无线系统，以满足神经科学界日益增长的需求。 第一阶段的工作将导致多个headstage选项准备商业化，同时通知 第二阶段继续发展。在我们未来的工作中，我们将继续扩展我们的系统， 计数并减少闭环电刺激的延迟。

Project Summary Closed-loop stimulation is key to the study and treatment of neurological disorders. However, largely due to current wireless power demands, stimulation systems are restricted to wired connections, which impact natural behavior, induce motion artifacts, and limit complexity of study design. While a few wireless recording- only systems have been developed, the power demands of these devices prohibit the addition of wireless electrical stimulation while staying within size and weight limitations for smaller animal models. These limitations are roadblocks to the next phase of neuroscience research and clinical development. In this Phase I, 1.5 year, STTR project, Spike Neuro is partnering with Duke University to develop a novel low power hybrid backscatter radio frequency system to enable the commercialization of a series of wireless recording and electrical stimulation headstages for small and large animal electrophysiology research. This innovative wireless technology shifts the high-power demand features out of the headworn components to the base station, significantly reducing battery size and weight enabling the addition of the electrical stimulation components and allowing for more flexibility in recording only experiments. This development work will result in two headstage options for small animals with 5 and 16 channels of recording and 2 channels of electrical stimulation and two slightly larger systems for 32 and 64 channels of recording with 8 channels of electrical stimulation. Aim 1 focuses on the development of the 5 and 16 channel systems and the electrical stimulation integration. Aim 2 will build upon the efforts in Aim 1 to expand the system to up to 64 channels with 8 channels of electrical stimulation. Both aims will also include hardware and software integration with the Spike Neuro data acquisition system. Aim 3 will conclude with benchtop and in vivo validation of our system to demonstrate successfully achieving key features needed for a commercial wireless recording and stimulation headstage. This proposal brings together a strong team of experts in wireless technology, electrophysiology, and commercialization to develop a wireless system that meets the growing needs of the neuroscience community. The Phase I work will result in a multiple headstage options ready for commercialization while informing continued Phase II development. In our future work, we will continue to scale our system to increase channel count and reduce the latency of the closed-loop electrical stimulation.