A new model system for assessing the socio-environmental determinants of the pace of aging: leveraging a long-term study of wild capuchins
评估衰老速度的社会环境决定因素的新模型系统:利用对野生卷尾猴的长期研究
基本信息
- 批准号:10696141
- 负责人:
- 金额:$ 26.01万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-15 至 2024-08-31
- 项目状态:已结题
- 来源:
- 关键词:AccelerationAddressAdrenal GlandsAdultAgeAgingAmericasAnimal ModelAssessment toolBackBehavior assessmentBehavioralBiologicalBiological AgingBiological MarkersBiological ModelsBirthBrainCapuchin MonkeyChronologyComplexCosta RicaDataData CollectionData SetDevelopmentDiet HabitsDimensionsDroughtsElderlyEnvironmental Risk FactorEpigenetic ProcessFemaleFruitGait speedGenerationsGeriatric AssessmentHealthHeterogeneityHumanIn SituIndividualIndividual DifferencesInflammationKnowledgeLaboratoriesLifeLife Cycle StagesLife ExpectancyLife ExperienceLife StyleLinkLiteratureLongevityLongitudinal StudiesMeasuresMethodsMissionModelingMolecularMonitorOnset of illnessOutcomePatternPersonal SatisfactionPhasePhenotypePhysical FunctionPhysical environmentPhysiologicalPopulationPositioning AttributePrimatesProcessProductivityProteomePublic HealthRainResearchSamplingSex DifferencesSocial BehaviorSocial EnvironmentSourceStatistical ModelsTechniquesTemperatureTestingUnited States National Institutes of HealthVariantWild Animalsage relatedanalogbehavior measurementbehavior observationbody systemexperiencefield studygenetic pedigreegut microbiomehealth assessmenthealth care availabilityhealth disparityhealthspanhuman old age (65+)immune functionindividual variationinnovationinsightintergenerationallife historylongitudinal analysislongitudinal, prospective studymalemembermolecular domainnonhuman primatenovelphysical conditioningpopulation basedsocialsocial adversitysocial groupsocial relationshipssocioenvironmental factortraittranslational study
项目摘要
PROJECT SUMMARY
One of the most enduring questions in public health is why some individuals retain good health into old age
while others experience declines in health, physical function, and wellbeing. Growing evidence indicates that
socio-environmental factors can contribute to individual differences in the progression of ‘biological aging’, yet
we lack a clear understanding of how they influence different body systems. Although these questions have
been difficult to address in humans, wild populations of primates offer unique opportunities for progress.
This project’s overarching objective is to generate new insights into how social and physical environments
influence heterogeneity in rates of aging and health disparities. We will accomplish this by developing a new
model system for the study of biological aging, using a combination of field-based behavioral observation and
laboratory analyses of noninvasive biological samples from wild white-faced capuchins. Our long-term
longitudinal study of this species allows us to leverage almost 40 years of granular data on life-histories,
pedigrees, and social behavior, as well as a rich assortment of associated data on the physical environment.
The traits that capuchins share with humans, including complex social relationships, omnivory, large brains,
and extended longevity, make them well-situated to provide insights into aging and health in our own species.
Our first Aim for the Development Phase is to identify, validate, and characterize biomarkers of aging and
health in physiological and molecular domains from non-invasive biological samples in a cross-section of adult
capuchins of known ages (6-27 years). We have been at the forefront of developing cutting-edge techniques
for noninvasive biological sampling, through which we will expand the set of wild animal models in which
biological aging can be studied. Second, we will develop new behavioral assessments of physical function that
are analogs of common geriatric assessments, and quantify aspects of social adversity parallel to those linked
to poor health, reduced survival, or accelerated biological aging in humans. In the Implementation Phase, our
Aim is to test the contributions of social and physical environments to trajectories of health and aging across
the life course, including sex differences in these relationships. To accomplish this, we will analyze longitudinal
variation in the biomarkers and health assessments that we establish during the Development Phase, in
combination with our long-term contextual data.
By the study’s conclusion, we will have established an innovative wild animal model of health and aging, with
newly developed biomarkers to track aging processes in an exceptional breadth of different body systems and
extended phenotypes. By integrating these new measures with our outstanding long-term data, we will shed
new light on potential mechanisms that explain individual differences in the progression of aging, and in doing
so, take an important step toward understanding how to extend the years of active, healthy life in humans.
项目总结
项目成果
期刊论文数量(0)
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专利数量(0)
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Fernando Alonso Campos其他文献
Fernando Alonso Campos的其他文献
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{{ truncateString('Fernando Alonso Campos', 18)}}的其他基金
A new model system for assessing the socio-environmental determinants of the pace of aging: leveraging a long-term study of wild capuchins
评估衰老速度的社会环境决定因素的新模型系统:利用对野生卷尾猴的长期研究
- 批准号:
10513070 - 财政年份:2022
- 资助金额:
$ 26.01万 - 项目类别:
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