Obesity Prevention Targets for Down Syndrome

唐氏综合症的肥胖预防目标

• 批准号: 10696074
• 负责人: Lisa Ann Daunhauer
• 金额: $ 66.7万
• 依托单位: COLORADO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-03 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10696074
• 关键词: 6 year old; Adult; Affect; Age; Attention; Birth; Body Weight; Caregivers; Child; Childhood; Chronology; Clinical Data; Collection; Congenital Heart Defects; Data; Development; Diagnosis; Diet; Dietary intake; Disease; Down Syndrome; Early identification; Energy Intake; Enrollment; Ensure; Family; Family dynamics; General Population; Goals; Growth; Health; Height; Hypothyroidism; Individual; Intake; Intellectual functioning disability; Knowledge; Learning; Life Expectancy; Longevity; Macronutrients Nutrition; Measures; Medical; Medical History; Modeling; Motor; Motor Skills; Obesity; Obesity Epidemic; Obstructive Sleep Apnea; Outcome; Overweight; Participant; Personal Satisfaction; Persons; Phenotype; Physical activity; Prevalence; Prevention; Probability; Proxy; Reporting; Research; Research Personnel; Risk; Risk Factors; Risk Reduction; Sampling; Science; Seasons; Site; Sleep; Time; Toddler; Underserved Population; United States National Institutes of Health; Visit; Walking; Weight; Weight Gain; aged; aspirate; caregiving; dietary; early childhood; experience; feeding; follow-up; foot; high risk; high risk population; improved; individual variation; longitudinal design; neurogenetics; non-alcoholic fatty liver disease; nutrition; obese person; obesity in children; obesity prevention; obesity risk; overweight child; primary caregiver; prospective; protective factors; recruit; resilience factor; sex; skill acquisition; social

PROJECT SUMMARY ABSTRACT Children with Down syndrome (DS) are disproportionately affected by the obesity epidemic, presenting a prevention challenge that is currently unmet. Despite improved life expectancies, people with DS experience poor health.10 Children and adults with DS have significantly higher rates of overweight/obesity (OW/OB) than those with intellectual disability from other causes11 or the general population.12 These risks are rooted in childhood, with rapid increases in OW/OB observed between ages 2 and 6 years in children with DS2–4 and childhood OW/OB conferring a higher risk for OW/OB in adulthood.2,3 However, research examining young children with DS+OW/OB has primarily focused on prevalence rates using retrospective clinical data, with minimal attention to modifiable prevention targets.2,11,13 Consequently, critical questions regarding how DS phenotypic factors such as co-occurring conditions, motor delays, and feeding challenges contribute to OW/OB risk remain unanswered. Despite being a specific, high-risk population for obesity, no prospective, longitudinal DS research has comprehensively characterized OW/OB predictors to guide effective prevention in early childhood when such efforts may enhance downstream health outcomes. Bridging this knowledge gap recently highlighted by prominent DS researchers,18 our team representing expertise in early development in DS, nutrition, and obesity in DS, physical activity (PA), and sleep, will use a longitudinal design to identify early OW/OB prevention targets for young children with DS. Using a staggered wave approach, we will enroll and assess 1/3 of the sample in Wave 1/Y1, with annual follow-up visits (+ 1 month) in Y2&3, using the same approach for Wave 2 (Y2-4) and Wave 3 (Y3-5), thus reducing recruitment demands over time and sites (total project n=160). At T1-3, we will collect data on (a) child factors—objectively measured PA, motor abilities (gross, fine, motor planning), sleep, and weight/height, plus caregiver-reported child dietary intake (energy, macronutrients, and dietary quality), child developmental and medical history, and feeding abilities; and (b) caregiving factors—caregiver feeding and PA practices, family dynamics, caregiver weight/height, and SES. At T1, we will recruit caregivers and their child with DS chronological ages 18-40 months, who walk 15+ feet independently. The age range ensures participant ages align with: (1) the full range of developmental variability expected in children with DS given that 95% of children with DS reach this walking milestone between 18-40 months (median = 24 months),5 and (2) observed weight gain increases between 2 to 6 years of age in DS,2–4 with 4-6 year-olds 61% more likely to have OB than those aged 2-3 years.2 The overarching project goal is to understand variability in risks for OW/OB in DS and identify prevention targets in young children with DS. Our long-term goal is to develop and deliver obesity prevention in early childhood to reduce risks for OW/OB and associated medical sequelae across the lifespan for individuals with DS.

项目摘要