P30 Center Core Grant for Vision Research

P30 中心视觉研究核心资助

• 批准号: 10696213
• 负责人: Raju VS Rajala
• 金额: $ 29.49万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10696213
• 关键词: Animal Experimentation; Animal Model; Animals; Area; Breeding; Center Core Grants; Collaborations; Core Grant; Data; Data Analyses; Data Collection; Dedications; Disease model; Electrophysiology (science); Electroretinography; Environment; Equipment; Eye diseases; Faculty; Fostering; Funding; Genotype; Glaucoma; Grant; Guidelines; Health Sciences; Housing; Human Resources; Humidity; Hyperoxia; Hypoxia; Image; Infection; Inflammation; Laboratories; Light; Location; Microscopy; Modeling; Mus; Oklahoma; Ophthalmoscopy; Optical Coherence Tomography; Pathogenesis; Physiology; Postdoctoral Fellow; Reproducibility; Research; Research Personnel; Scientist; System; Therapeutic; Training; Training and Education; Transgenic Animals; Universities; Vision; Vision research; animal imaging; animal model development; dark rearing; experimental analysis; experimental study; graduate student; in vivo; instrument; instrumentation; laser photocoagulation; recruit; skills; tonometry; user-friendly; vision development

ABSTRACT Animal Analysis Core Vision research requires the use of various animal models to investigate the mechanisms of visual development and degeneration, the pathogenesis of blinding infection and inflammation, and the efficacy of vision-saving therapeutics. The Live Animal Imaging and Functional Analysis Core at the University of Oklahoma Health Sciences Center is responsible for providing vision researchers with state-of-the-art instrumentation in the physiology and function of vision in small animal models of development, degeneration, infection, and inflammation. These Cores support vision research on 16 NEI-funded R01 grants and other vision-related projects at OUHSC in two different locations within vivaria, which allows in/out privileges. More than 40 ocular disease models and more than 70 genetically altered mouse lines are currently being analyzed with electrophysiological, genotyping, functional analysis, microscopy, and other support equipment in expanded research areas renovated specifically for this use. The instrumentation provided by this Core includes electroretinography (in vivo and ex vivo), optical coherence tomography, fundoscopy, optokinetics, laser photocoagulation, tonometry, indirect ophthalmoscopy, and slit lamp and biomicroscopic imaging. Environmental housing also includes equipment for light damage, dark rearing, hypoxia/hyperoxia, controlled humidity, and glaucoma models. Genotyping provides accurate data for breeding transgenic animals for vision research. Our Systems Managers are highly skilled in training personnel, assisting with experiments and data analysis, and maintaining core equipment to a quality standard. As such, this Core consolidates and provides instrumentation and expertise which would otherwise be too expensive or logistically difficult for vision researchers across campus to easily access. As in the previous funding period, this Core is motivated and committed to providing an effective, efficient, user-friendly, and high-quality research environment for all vision researchers at OUHSC.

摘要 动物分析核心 视觉研究需要使用各种动物模型来研究视觉的机制。 发展和退化，致盲性感染和炎症的发病机制，以及 拯救视力的疗法美国密歇根大学活体动物成像和功能分析中心 俄克拉荷马州健康科学中心负责为视觉研究人员提供最先进的 在发育，退化， 感染和炎症。这些核心支持16个NEI资助的R 01赠款和其他 视觉相关的项目在OUHSC在两个不同的地点在vivaria内，这允许在/出特权。更 目前正在分析40多个眼病模型和70多个转基因小鼠品系 与电生理学，基因分型，功能分析，显微镜和其他支持设备， 扩大研究领域，专门为此目的进行了翻新。本核心提供的仪器 包括视网膜电图（体内和体外）、光学相干断层扫描、眼底镜检查、验光 激光光凝法、眼压测量法、间接检眼镜检查法、裂隙灯和生物显微镜成像。 环境饲养还包括用于光损伤、黑暗饲养、缺氧/高氧、受控 湿度和青光眼模型。基因分型为培育视力转基因动物提供准确数据 research.我们的系统经理在培训人员、协助实验和数据方面具有很高的技能 分析和维护核心设备的质量标准。因此，此核心整合并提供 仪器和专业知识，否则将过于昂贵或后勤困难的愿景 研究人员在校园内轻松访问。与上一个供资期一样，这一核心是有动力的， 致力于为所有愿景提供有效，高效，用户友好和高质量的研究环境 OUHSC的研究人员。