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Understanding the role of schools in supporting HIV treatment outcomes among HIV infected adolescents

了解学校在支持艾滋病毒感染青少年的艾滋病毒治疗结果方面的作用

基本信息

批准号：
10672257
负责人：
Irene Nyambura Njuguna
金额：
$ 11.96万
依托单位：
KENYATTA NATIONAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-17 至 2025-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10672257
关键词：
Absenteeism Achievement Acquired Immunodeficiency Syndrome Adherence Adolescence Adolescent Adult Africa Africa South of the Sahara Age Authorization documentation Award Caregivers Caring Cessation of life Child Chronic Disease Clinic Clinic Visits Clinical Country Decision Making Development Disclosure Distant Education Enrollment Fright Future Goals Guidelines HIV HIV-infected adolescents Health Health Personnel Health Services Accessibility Hospitals Influentials Infrastructure Intervention Interview Kenya Life Link Maps Medicine Mentors Methods Nurses Outcome Peer Group Performance Pharmaceutical Preparations Policies Policy Maker Population Positioning Attribute Primary Schools Privacy Procedures Process Productivity Reporting Research Research Design Research Methodology Research Personnel Research Training Retrospective cohort study Role Sahara Schedule School Health Services School Nursing School-Age Population Schools Scientist Secondary Schools Secondary to Services Shapes Stigmatization Structure Surveys Teacher Professional Development Testing Training Training Support Treatment outcome United States National Institutes of Health Viral Work aged antiretroviral therapy career clinical epidemiology effective intervention effectiveness testing experience group intervention human centered design implementation science improved improved outcome multidisciplinary peer peer support pill preference school environment school health skills social stigma teacher therapy development tool

项目摘要

PROJECT SUMMARY/ABSTRACT The overall goal of the proposed K43 Emerging Global Leader Award (non-clinical trials requirement) is to support Dr. Njuguna’s research training to develop an independent career in HIV research. Dr. Njuguna is a research scientist at the Kenyatta National Hospital, Nairobi, Kenya. The proposed work examines the unique intersection between education and health in the context of adolescent HIV. Dr. Njuguna’s training goals are to gain expertise in human centered design for intervention development, implementation science (IS), mixed methods and adolescent research. This work will also provide an opportunity to work closely with policy makers, and link clinical epidemiology skills she has previously acquired with real world IS methods. The proposal leverages a multidisciplinary team of mentors and collaborators who will ultimately support Dr. Njuguna’s goal to become a productive and influential independent investigator in adolescent HIV research. The research goal of this proposal is to use a human centered design approach by utilizing mixed methods research to gain an in-depth understanding of the school environment and its contribution to achieving treatment goals, and to collaboratively and iteratively develop a school-based intervention to improve outcomes among school-going adolescents living with HIV (ALWHIV). There is a growing population of ALWHIV surviving to adulthood. These children need support to sustain medication use during adolescence and across school and life transitions. There is limited evidence on school-based interventions to support treatment, despite the fact that most ALWHIV are enrolled in school (including boarding schools). The Aims of this proposal are: 1.To evaluate existing school-based structures available for ALWHIV and key determinants of caregiver and ALWHIV school choice decisions, 2.To determine school-related correlates of viral suppression and retention in care, 3.To develop and pilot a school staff training and peer support intervention in selected schools for non-health outcomes (acceptability, feasibility and appropriateness). This is the first study to our knowledge to propose to quantitatively characterize school-related correlates of clinical outcomes in sub-Sahara Africa (SSA) and evaluate factors influencing school choice for ALWHIV. The study brings together a diverse team of stakeholders from the Kenyan national Education and Health sectors and utilizes a multi-step approach to achieve study objectives. This approach will allow for rigorous intervention development process, and pave way for a strong collaborative effort in a future R01 to test effectiveness of a school-based intervention package to improve outcomes, including viral suppression, in school-going ALWHIV, that could potentially benefit adolescents with other non-HIV chronic illnesses. Dr. Njuguna’s research goals correspond with her training goals, and at the completion of this award, she will be in an excellent position to submit an R01 application to further advance research in ALWHIV.

项目总结/文摘