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Simulation Modeling of Hepatitis B Virus Elimination Strategies in Cote d'Ivoire

科特迪瓦乙型肝炎病毒消除策略的模拟建模

基本信息

批准号：
10673196
负责人：
Amir Mohareb
金额：
$ 13.55万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-08-01 至 2027-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10673196
关键词：
Address Adult Africa Africa South of the Sahara Antiviral Agents Antiviral Therapy Applied Skills Area Award Biometry Caring Cessation of life Chronic Hepatitis B Cirrhosis Clinical Clinical Investigator Clinical Practice Guideline Collaborations Communicable Diseases Complex Computer Simulation Cost Effectiveness Analysis Country Data Derivation procedure Diagnostic Diagnostic tests Disease Drug Side Effects Economics Eligibility Determination Europe Far East Flare Foundations Future Goals Guidelines HIV Health Benefit Healthcare Hepatitis Hepatitis B Hepatitis B Infection Hepatitis B Therapy Hepatitis B Virus Immunotherapy Incidence International Investigation Ivory Coast Laboratories Liver Liver Fibrosis Malaria Malignant neoplasm of liver Measures Mentored Research Scientist Development Award Mentors Mentorship Methodology Modeling Monitor North America Nucleic Acid Amplification Tests Outcome Patients Persons Physicians Policy Maker Positioning Attribute Prevention Primary carcinoma of the liver cells Productivity Public Health Records Research Research Personnel Research Project Grants Resource-limited setting Resources Safety Solid Strategic Planning Training Tuberculosis United States National Institutes of Health Vaccination Vaccines Validation Viral Viral hepatitis Virus Withholding Treatment World Health Organization alternative treatment career chronic liver disease clinical epidemiology cost cost effectiveness design didactic education economic outcome elastography evidence base fighting improved liver biopsy model design models and simulation mortality mortality risk multidisciplinary multiple data sources novel prevent scale up skills standard of care success tool treatment guidelines treatment strategy viral DNA years of life lost

项目摘要

Project Summary Hepatitis B virus (HBV) is the world's leading cause of cirrhosis, liver cancer, and liver-related mortality. Its burden is increasing around the world, especially in sub-Saharan Africa. Even though millions of people across sub-Saharan Africa are known to have chronic hepatitis B infection, very few eligible patients are started on treatment. The complexity and cost of laboratory monitoring, liver fibrosis assessments, and antiviral treatment are some of the major challenges preventing scale-up of treatment. My goal is to determine whether hepatitis B management guidelines can be simplified so that limited healthcare resources are focused on expanding hepatitis B treatment in resource-limited settings. Simulation models are evidence-based tools that are increasingly being used by investigators to address complex questions such as this, by assessing the long-term clinical impact of existing as well as novel hepatitis B treatment initiation strategies. I am an Infectious Diseases physician with a research background in clinical epidemiology, simulation modeling, and cost-effectiveness analysis. I am motivated to expand on my current skillset and gain training to apply these methodologies to investigate HBV treatment strategies in sub-Saharan Africa. The Mentored Research Scientist Development Award will afford me the opportunity to gain the necessary skills to become an independent clinical investigator. I require specific training in (1) model design and validation; (2) derivation of clinical and economic outcome data; and (3) designing and executing cost-effectiveness analyses. I have designed a didactic curriculum to address each of these training aims. I have also assembled a multi-disciplinary team of mentors and collaborators with methodological and/ or content expertise who are devoted to my success in achieving the aims of this proposal. By the end of the award period, I will have designed and validated a novel HBV simulation model, populated the model with clinical and economic data from sub-Saharan Africa, and used the model conduct a high impact cost-effectiveness analysis that has the potential to guide HBV management across the continent.

项目总结