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An Unobtrusive Continuous Cuff-less Blood Pressure Monitor for Nocturnal Hypertension

一种用于夜间高血压的不显眼的连续无袖血压监测仪

基本信息

批准号：
10673872
负责人：
Roozbeh Jafari
金额：
$ 68.48万
依托单位：
TEXAS ENGINEERING EXPERIMENT STATION
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-06-01 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10673872
关键词：
Adherence Adult Affect Age Ambulatory Blood Pressure Monitoring Antihypertensive Agents Arteries Awareness Biometry Blood Pressure Blood Pressure Monitors Blood Volume Blood flow Calibration Cardiac Cardiovascular Diseases Cardiovascular system Caregivers Characteristics Clinical Data Data Collection Derivation procedure Development Devices Early Diagnosis Environment FDA approved Feedback Future Healthcare Heart Rate Home Hour Human Hypertension Investigation Learning Legal patent Life Link Literature Machine Learning Marketing Measurement Measures Mercury Methods Microfabrication Modeling Monitor Morphologic artifacts Motion Movement Nature Nocturnal Hypertension Organ Outcome Outcomes Research Participant Patient Monitoring Patient risk Patients Pattern Penetration Pharmaceutical Preparations Physicians Physiologic pulse Physiology Positioning Attribute Proxy Recording of previous events Regimen Research Risk Risk Factors Science Signal Transduction Site Skin Sleep Sleep Deprivation Sphygmomanometers Structure Supination Supine Position System Techniques Technology Time Uncertainty Validation Variant Work World Health Organization Wrist advanced analytics analytical method arterial stiffness cohort comorbidity design digital effectiveness validation hypertensive insight instrument model development monitoring device motion sensor multidisciplinary novel novel strategies patient stratification patient subsets performance tests prognostic value response sensor sex sleep position wearable device wearable monitor wearable sensor technology willingness wrist worn device

项目摘要

PROJECT SUMMARY/ABSTRACT The objective of this project is to create an unobtrusive, wrist-worn, cuff-less blood pressure monitor for measurement and identification of nocturnal nondipping hypertension. The investigation includes extensive validation with state-of-the-art ambulatory blood pressure monitors at nighttime in presence of heterogeneous treatment paradigms. Cardiovascular disease (CVD) is one of the major causes of ailments worldwide. Hypertension alone affects one in three adults according to the World Health Organization. Therefore, monitoring blood pressure has become a critical part of healthcare as it is known to be linked to many CVDs. Traditionally, clinical practitioners have relied on the mercury-based (or digital equivalent) inflatable cuff-based sphygmomanometer. However, the nature of the device allows for only infrequent measurements and its somewhat invasive nature and associated discomfort prohibits additional nocturnal measurements. There is certainly a value to measuring blood pressure continuously in the natural context of the user’s environment, in particular during sleep, without being disturbed by the instrument. Our proposed technology can provide a wealth of information to physicians, help identify certain short-term dynamics/variations of blood pressure, and allow effective monitoring of response to medication, among other things. Nocturnal measurements provide additional prognostic value in identifying risk. Despite these benefits, no wearable, non-invasive device for continuous blood pressure monitoring exists on the market simply because none have been reliable enough to be considered clinical grade. This project aims to develop a robust and reliable blood pressure monitor in the form of a wrist-worn device that uses bio-impedance sensors, and for the first time, demonstrate clinical grade reliability. These sensors measure pulse wave velocity (PWV) along with several other derivatives for cardiovascular parameters including heart rate and blood volume changes in arteries, which correlate with the blood pressure. The system will incorporate clever hardware design to localize underlying vasculature and focus on arterial sites for enhanced accuracy. The device will include a motion sensor to take into account the user’s movements and motion artifacts, the contact quality, and reliability of the measurements. Advanced machine learning techniques, leveraging both general and personalized models, will be developed to convert bio-impedance measurements to blood pressure. This project aims to then validate the system and analytics in both a healthy patient cohort and a hypertensive cohort, learning the impact that nocturnal ‘nondipping’ hypertension and anti-hypertensive treatments have on PWV/other cardiovascular correlates and blood pressure estimates. After decades of relying on the inflatable cuff- based technique, this system could represent a significant change in how we measure blood pressure.

项目总结/文摘

项目成果

期刊论文数量（11）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Continuous cuffless blood pressure monitoring with a wearable ring bioimpedance device.

DOI：
10.1038/s41746-023-00796-w
发表时间：
2023-03-30
期刊：
NPJ digital medicine
影响因子：
15.2
作者：
通讯作者：

Physics-informed neural networks for modeling physiological time series for cuffless blood pressure estimation.

DOI：
10.1038/s41746-023-00853-4
发表时间：
2023-06-09
期刊：
NPJ digital medicine
影响因子：
15.2
作者：
通讯作者：

Amphiphilic silicones for the facile dispersion of carbon nanotubes and formation of soft skin electrodes.

DOI：
10.1021/acsapm.2c01757
发表时间：
2022-12
期刊：
ACS applied polymer materials
影响因子：
5
作者：
A. Marmo;Lucas R. Lott;J. H. Pickett;Harrison E. Koller;Brandon M. Nitschke;M. Grunlan
通讯作者：
A. Marmo;Lucas R. Lott;J. H. Pickett;Harrison E. Koller;Brandon M. Nitschke;M. Grunlan

Cuffless blood pressure monitoring from a wristband with calibration-free algorithms for sensing location based on bio-impedance sensor array and autoencoder.