The Institute for Translational Medicine

转化医学研究所

• 批准号: 10673867
• 负责人: Joshua J Jacobs
• 金额: $ 822.05万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-06 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10673867
• 关键词: Accounting; Acute Pain; Address; Advocate; Behavioral; Biological; COVID-19 patient; Chicago; Chronic; Clinical Data; Clinical Research; Clinical Sciences; Clinical Treatment; Clinical Trials Network; Communication; Communities; Comprehensive Health Care; Conceptions; Data; Disease; Diverse Workforce; Drug abuse; Ecosystem; Equity; Ethics; Funding; Goals; Health; Health Personnel; Health system; Healthcare; Helmet; Home; Human; Human Biology; Illinois; Image; Impaired health; Individual; Informatics; Infrastructure; Injury; Institution; Intervention; Investments; Joints; Knowledge; Longevity; Malignant Childhood Neoplasm; Mechanical ventilation; Medical Imaging; Methods; Modeling; Morbidity - disease rate; Patients; Phase; Physicians; Post-Acute Sequelae of SARS-CoV-2 Infection; Process; Psychological Factors; Research; Research Personnel; Research Training; Resources; Role; Science; Scientist; Societies; Source; Special Population; Structural Racism; System; Technology; Testing; Training; Translational Research; United States National Institutes of Health; Universities; Vision; Work; biological systems; clinical practice; cost; data resource; de novo mutation; design; disorder risk; experience; food insecurity; genomic data; health equity; improved; improved outcome; innovation; lens; metropolitan; mortality; multidisciplinary; pandemic disease; programs; social; social determinants; somatosensory; tool; translational medicine

ABSTRACT ITM 3.0: ADVANCING HEALTH TOWARD HEALTH EQUITY THROUGHOUT METROPOLITAN CHICAGO The University of Chicago – Rush University Institute for Translational Medicine (ITM) was created in 2007 to assemble, integrate, and create the intellectual, administrative, and physical resources required to catalyze research and research training in Clinical and Translational Science. We have trained university scientists and health care providers as well as stakeholders from concerned communities to work together to determine the biological, behavioral, and social determinants of disease; to develop and test interventions directed toward those mechanisms; and to achieve these goals in a way that is rigorous, efficient, ethical, respectful of, and responsive to our communities’ priorities and values. The ITM has capitalized on outstanding intellectual and physical resources throughout UChicago, Rush, and ITM affiliate institutions – Loyola University Chicago, NorthShore University HealthSystem, Advocate Aurora Health Care, and Illinois Institute of Technology – and on substantial multi-institutional investments to build the sustainable infrastructure for a transformative, energetic, and self-improving home for clinical and translational research. Now, we pursue a bold guiding vision for “ITM 3.0” – that reversing the adverse health consequences of structural racism requires accounting for and mitigating the social, environmental, behavioral, and psychological factors (the entire lived experience, which we will call the “sociome”) through which structural racism impairs health. Focus on the sociome is critical because: 1) sociome factors interact with human biology to exacerbate or cause disease and injury, and 2) illness of any origin can compound the negative effects of adverse sociome factors. Since both sociome and biological systems, and their interactions, determine health, our CTSA hub must provide investigators, trainees, and stakeholders with the resources and knowledge to account for and address health disruptors throughout both systems. Our strategy to implement this vision is to create new training mechanisms, research platforms, communications channels, and safeguards against harm to ensure that all ITM investigators and institutions approach health problems with a wider-angle sociome lens in an ethical way. Then, our scientific, institutional, and community stakeholders can together design, test, and disseminate biological and/or sociome-directed interventions at the levels of individual, community, and society to improve mutually defined health concerns. ITM 3.0 will work hand-in-hand with partners throughout Chicagoland and the nation, combining academic rigor with community wisdom to conceptualize, develop and deploy innovative, just, and ethical interventions/practices to achieve our common goal, and so lessen the health impact of structural racism.

摘要 ITM 3.0：在整个芝加哥大都会推进健康朝着健康公平方向发展 芝加哥大学-拉什大学转化医学研究所(ITM)成立于2007年，旨在 整合、整合和创造催化所需的智力、管理和物质资源 临床和转化科学的研究和研究培训。我们培养了大学科学家和 卫生保健提供者以及相关社区的利益相关者共同努力确定 疾病的生物、行为和社会决定因素；开发和测试针对以下目标的干预措施 这些机制；并以严格、高效、道德、尊重和 响应我们社区的优先事项和价值观。ITM利用了杰出的知识分子和 芝加哥大学、拉什大学和ITM附属机构的实物资源-洛约拉大学芝加哥分校， NorthShore University HealthSystem、Advocate Aurora Health Care和伊利诺伊理工学院-以及 关于大规模的多机构投资，以建设可持续的基础设施， 精力充沛，自我完善的临床和翻译研究之家。 现在，我们为“ITM 3.0”追求一个大胆的指导性愿景--扭转 结构性种族主义需要考虑和减轻社会、环境、行为和 心理因素(整个生活体验，我们将其称为“社会体”)，通过它 结构性种族主义损害健康。关注社会群体是至关重要的，因为：1)社会群体因素与 人类生物学加剧或导致疾病和伤害，以及2)任何来源的疾病都会使 不良社会因素的负面影响。因为社会系统和生物系统，以及它们的 互动，决定健康，我们的CTSA中心必须为调查人员、受训人员和利益相关者提供 说明和解决两个系统中的健康干扰因素的资源和知识。我们的 实现这一愿景的战略是创建新的培训机制、研究平台、 通信渠道，以及防止伤害的保障措施，以确保所有ITM调查人员和 各机构以道德的方式，以更广泛的社会视角来处理健康问题。那么，我们的 科学、机构和社区利益相关者可以共同设计、测试和传播生物学 和/或以社会为导向的个人、社区和社会层面的干预措施，以改善 相互界定的健康问题。ITM 3.0将与整个芝加哥和 国家，结合学术严谨和社区智慧来概念化、开发和部署 创新、公正和合乎道德的干预措施/做法，以实现我们的共同目标，从而减少健康 结构性种族主义的影响。

项目成果

The Effect of Body Mass Index and Weight-Adjusted Fluid Dosing on Mortality in Sepsis.

• DOI: 10.1177/0885066620973917
• 发表时间: 2022-01
• 期刊: Journal of intensive care medicine
• 影响因子: 3.1
• 作者: Ward MA;Kuttab HI;Lykins V JD;Wroblewski K;Hughes MD;Keast EP;Kopec JA;Rourke EM;Purakal J
• 通讯作者: Purakal J

Opioid use as a potential risk factor for pancreatic cancer in the United States: An analysis of state and national level databases.

• DOI: 10.1371/journal.pone.0244285
• 发表时间: 2021
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Barlass U;Deshmukh A;Beck T;Bishehsari F
• 通讯作者: Bishehsari F

Effect Modification by Social Determinants of Pharmacogenetic Medication Interactions on 90-Day Hospital Readmissions within an Integrated U.S. Healthcare System.

• DOI: 10.3390/jpm12071145
• 发表时间: 2022-07-15
• 期刊: JOURNAL OF PERSONALIZED MEDICINE
• 作者: Saulsberry, Loren;Singh, Lavisha;Pruitt, Jaclyn;Ward, Christopher;Wake, Dyson T.;Gibbons, Robert D.;Meltzer, David O.;O'Donnell, Peter H.;Cruz-Knight, Wanda;Hulick, Peter J.;Dunnenberger, Henry M.;David, Sean P.
• 通讯作者: David, Sean P.

Comparison of machine learning and deep learning for view identification from cardiac magnetic resonance images.

• DOI: 10.1016/j.clinimag.2021.11.013
• 发表时间: 2022-03
• 期刊: Clinical imaging
• 影响因子: 2.1
• 作者: Chauhan D;Anyanwu E;Goes J;Besser SA;Anand S;Madduri R;Getty N;Kelle S;Kawaji K;Mor-Avi V;Patel AR
• 通讯作者: Patel AR

Discordance in Objective and Self-perceived HIV Risk: A Potential Barrier to Pre-exposure Prophylaxis in Young Gay and Bisexual Men.

• DOI: 10.1097/jnc.0000000000000137
• 发表时间: 2020-01
• 期刊: The Journal of the Association of Nurses in AIDS Care : JANAC
• 作者: Oostrom L;Rosentel K;Motley D;Hill BJ
• 通讯作者: Hill BJ