The Institute for Translational Medicine

转化医学研究所

• 批准号: 10632295
• 负责人: Joshua J Jacobs
• 金额: $ 829.87万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-06 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10632295
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Contact PD/PI: Solway, Julian Chapter O: Overall ABSTRACT ITM 3.0: ADVANCING HEALTH TOWARD HEALTH EQUITY THROUGHOUT METROPOLITAN CHICAGO The University of Chicago – Rush University Institute for Translational Medicine (ITM) was created in 2007 to assemble, integrate, and create the intellectual, administrative, and physical resources required to catalyze research and research training in Clinical and Translational Science. We have trained university scientists and health care providers as well as stakeholders from concerned communities to work together to determine the biological, behavioral, and social determinants of disease; to develop and test interventions directed toward those mechanisms; and to achieve these goals in a way that is rigorous, efficient, ethical, respectful of, and responsive to our communities’ priorities and values. The ITM has capitalized on outstanding intellectual and physical resources throughout UChicago, Rush, and ITM affiliate institutions – Loyola University Chicago, NorthShore University HealthSystem, Advocate Aurora Health Care, and Illinois Institute of Technology – and on substantial multi-institutional investments to build the sustainable infrastructure for a transformative, energetic, and self-improving home for clinical and translational research. Now, we pursue a bold guiding vision for “ITM 3.0” – that reversing the adverse health consequences of structural racism requires accounting for and mitigating the social, environmental, behavioral, and psychological factors (the entire lived experience, which we will call the “sociome”) through which structural racism impairs health. Focus on the sociome is critical because: 1) sociome factors interact with human biology to exacerbate or cause disease and injury, and 2) illness of any origin can compound the negative effects of adverse sociome factors. Since both sociome and biological systems, and their interactions, determine health, our CTSA hub must provide investigators, trainees, and stakeholders with the resources and knowledge to account for and address health disruptors throughout both systems. Our strategy to implement this vision is to create new training mechanisms, research platforms, communications channels, and safeguards against harm to ensure that all ITM investigators and institutions approach health problems with a wider-angle sociome lens in an ethical way. Then, our scientific, institutional, and community stakeholders can together design, test, and disseminate biological and/or sociome-directed interventions at the levels of individual, community, and society to improve mutually defined health concerns. ITM 3.0 will work hand-in-hand with partners throughout Chicagoland and the nation, combining academic rigor with community wisdom to conceptualize, develop and deploy innovative, just, and ethical interventions/practices to achieve our common goal, and so lessen the health impact of structural racism. Project Summary/Abstract Page 244 Contact PD/PI: Solway, Julian

联系人 PD/PI：Solway、Julian O 章：总体 抽象的 ITM 3.0：在整个芝加哥大都会促进健康，实现健康公平 芝加哥大学-拉什大学转化医学研究所 (ITM) 成立于 2007 年， 汇集、整合和创造催化所需的智力、管理和物质资源 临床和转化科学的研究和研究培训。我们培养了大学科学家和 卫生保健提供者以及相关社区的利益相关者共同努力确定 疾病的生物学、行为和社会决定因素；制定和测试针对以下目标的干预措施 这些机制；并以严格、高效、道德、尊重和尊重的方式实现这些目标 响应我们社区的优先事项和价值观。 ITM 充分利用了杰出的智力和 整个芝加哥大学、Rush 和 ITM 附属机构（芝加哥洛约拉大学）的物理资源， 北岸大学医疗系统、Advocate Aurora Health Care 和伊利诺伊理工学院 – 以及 进行大量多机构投资，建设可持续基础设施，以实现变革、 充满活力、自我完善的临床和转化研究之家。 现在，我们追求“ITM 3.0”的大胆指导愿景——扭转对健康的不利影响 结构性种族主义需要考虑和减轻社会、环境、行为和 心理因素（整个生活经历，我们称之为“社会组”） 结构性种族主义损害健康。关注社会群体至关重要，因为：1）社会群体因素与 人类生物学加剧或导致疾病和伤害，2) 任何来源的疾病都可能加剧 不良社会因素的负面影响。由于社会组和生物系统及其 相互作用、确定健康状况，我们的 CTSA 中心必须为调查人员、受训人员和利益相关者提供 资源和知识来解释和解决两个系统中的健康干扰因素。我们的 实现这一愿景的战略是创建新的培训机制、研究平台、 沟通渠道，并防范伤害，以确保所有 ITM 调查员和 机构以更广泛的社会视角以道德的方式处理健康问题。那么，我们的 科学、机构和社区利益相关者可以共同设计、测试和传播生物技术 和/或在个人、社区和社会层面进行以社会为导向的干预措施，以改善 共同定义的健康问题。 ITM 3.0 将与整个芝加哥地区的合作伙伴携手合作 国家，将学术严谨性与社区智慧相结合来概念化、开发和部署 创新、公正和符合道德的干预措施/做法，以实现我们的共同目标，从而减少健康 结构性种族主义的影响。 项目总结/摘要第 244 页 联系人 PD/PI：Solway、Julian