Adaptive immunity to non-typeable H. influenzae in children with bronchiectasis

支气管扩张儿童对不可分型流感嗜血杆菌的适应性免疫

• 批准号: nhmrc : 1038415
• 负责人: Dr Susan Pizzutto
• 金额: $ 5.41万
• 依托单位: Menzies School of Health Research
• 依托单位国家: 澳大利亚
• 项目类别: Postgraduate Scholarships
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/adaptive-immunity-non-children-bronchiectasis/111135
• 关键词: Adaptive; immunity; non; typeable; H.

Bronchiectasis is a chronic disease of the lungs which affects at least 1 in 68 NT Indigenous children. It causes recurring lung infections, hospitalisations and deteriorating lung function. This study will provide important data on the immune response of Indigenous children to NTHi, the most important pathogen associated with chronic respiratory infections and why this immune response is not protective. This is the first step in targeting therapies to the prevention of bronchiectasis.

支气管扩张症是一种慢性肺部疾病，每68名台湾省土著儿童中至少有1名受到影响。它会导致反复的肺部感染、住院和肺功能恶化。这项研究将提供有关土著儿童对NTHi的免疫反应的重要数据，NTHi是与慢性呼吸道感染有关的最重要的病原体，以及为什么这种免疫反应不具有保护性。这是针对预防支气管扩张症的治疗的第一步。