Human Immune System Mouse Core

人体免疫系统鼠标核心

基本信息

  • 批准号:
    10675451
  • 负责人:
  • 金额:
    $ 53.96万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2004
  • 资助国家:
    美国
  • 起止时间:
    2004-07-01 至 2024-07-31
  • 项目状态:
    已结题

项目摘要

PROJECT SUMMARY/ABSTRACT Human Immune System Mouse Core (Core H) The Human Immune System Mouse Core (HISMC) will provide HU CFAR investigators with humanized mouse models in which to study human immunodeficiency virus (HIV) infection. In addition, the HISMC will support early career HU CFAR investigators to access these models through a Voucher program. Despite extensive correlative studies of HIV-infected persons and ex vivo studies of peripheral blood cells and tissue biopsies, fundamental questions about HIV pathogenesis and immunity remain unanswered. The ability to study HIV through controlled perturbations of the immune system is limited in human subjects, and limited access to human tissue samples makes the investigation of HIV replication and human immune responses to HIV difficult in compartments other than the blood. Investigators have therefore turned to animal models, but unfortunately an ideal animal model of HIV infection has remained elusive. Although simian immunodeficiency virus (SIV) infection of rhesus macaques has provided many critically important insights into retroviral pathogenesis and immunity, there are differences inherent in macaque immune responses to SIV and human responses to HIV. Moreover, expenses associated with NHP studies limit access to this model. To address these limitations, chimeric “humanized mice” with human immune cells have been generated. The HU CFAR HISMC generates complementary humanized mouse models: human peripheral blood leukocytes (hu-PBL) mice, hematopoietic stem cells (hu-HSC) mice and bone marrow-liver-thymus (BLT) mice. Studies supported by the HISMC have demonstrated that these mice recapitulate multiple aspects of HIV infection in humans such as the presence of an “eclipse phase” of infection following intravaginal challenge; similar depletion of CD4+ T cell in peripheral blood and mucosal tissues following infection; and support advanced in vivo imaging of HIV infection by multiphoton-intravital microscopy and bioluminescence imaging. They also offer a model to study the effect of treatment, such as ART or antibodies, against HIV. In the coming funding period, the HISMC will provide access to these models of humanized mice as a new MGH/Partners Healthcare Core. As such, all costs involved in the generation of the mice and their experimental manipulations are included in the price of the services. The CFAR support will be entirely directed towards a voucher program to support access of early career HU CFAR investigators to these services. These vouchers will cover costs related to humanized mice experiments and will be restricted to early career HU CFAR investigators who have no grant funding for humanized mouse studies from other sources.
项目摘要/摘要 人类免疫系统小鼠核心(核心H) 人类免疫系统小鼠核心(HISMC)将为HU CFAR研究人员提供人源化小鼠 研究人类免疫缺陷病毒(HIV)感染的模型。此外,HISMC将支持 早期职业生涯胡CFAR调查人员通过代金券计划访问这些模型。 尽管对艾滋病毒感染者进行了广泛的相关研究,并对外周血细胞和 组织活检、关于艾滋病毒发病机制和免疫的基本问题仍未得到回答。一种能力 通过受控的免疫系统扰动来研究艾滋病毒在人类受试者中是有限的,而且有限 获取人体组织样本使艾滋病毒复制和人类免疫反应的研究成为可能 艾滋病毒很难在血液以外的隔室中传播。因此,研究人员转向了动物模型,但 不幸的是,理想的艾滋病毒感染动物模型仍然难以找到。尽管猿猴免疫缺陷 猕猴的病毒(SIV)感染为研究逆转录病毒提供了许多至关重要的见解 致病机制和免疫,猕猴对SIV和人类的免疫反应存在固有的差异 对艾滋病毒的反应。此外,与NHP研究相关的费用限制了对这一模式的使用。致信地址 在这些局限性下,嵌合的“人源化小鼠”已经与人类免疫细胞产生了。HU CFAR HISMC建立互补的人源化小鼠模型:人外周血白细胞(Hu-PBL) 小鼠、造血干细胞(HU-HSC)小鼠和骨髓-肝脏-胸腺(BLT)小鼠。支持的研究 HISMC的研究表明,这些小鼠概括了人类感染艾滋病毒的多个方面 例如,在阴道内挑战后出现感染的“月食相”;类似的耗竭 感染后外周血和粘膜组织中的CD4+T细胞;并支持先进的体内成像 通过多光子活体显微镜和生物发光成像检测艾滋病毒感染。他们还提供了一个模型来 研究抗艾滋病毒治疗的效果,如抗逆转录病毒药物或抗体。 在接下来的资助期,HISMC将提供这些人源化小鼠模型作为一种新的 MGH/合作伙伴医疗保健核心。因此,小鼠及其后代所涉及的所有成本 服务的价格中包括了实验性的操纵。CFAR的支持将完全是 针对凭证计划,以支持早期职业生涯HU CFAR调查人员访问这些 服务。这些代金券将包括与人源化小鼠实验相关的费用,并将仅限于早期 职业胡CFAR研究人员,他们没有从其他来源获得人源化老鼠研究的赠款资金。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Alejandro Benjamin Balazs其他文献

Alejandro Benjamin Balazs的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Alejandro Benjamin Balazs', 18)}}的其他基金

AAV Vectored Delivery of Broadly Neutralizing Antibodies with Optimal Innate Functionality Against HIV
AAV 载体递送具有针对 HIV 的最佳先天功能的广泛中和抗体
  • 批准号:
    10762553
  • 财政年份:
    2023
  • 资助金额:
    $ 53.96万
  • 项目类别:
Human Immune System Mouse Core
人体免疫系统鼠标核心
  • 批准号:
    9764992
  • 财政年份:
    2019
  • 资助金额:
    $ 53.96万
  • 项目类别:
Development of Vectored ImmunoProphylaxis as a strategy against HIV
开发载体免疫预防作为抗 HIV 策略
  • 批准号:
    8411105
  • 财政年份:
    2014
  • 资助金额:
    $ 53.96万
  • 项目类别:
Human Immune System Mouse Core
人体免疫系统鼠标核心
  • 批准号:
    10238750
  • 财政年份:
    2004
  • 资助金额:
    $ 53.96万
  • 项目类别:
Human Immune System Mouse Core
人体免疫系统鼠标核心
  • 批准号:
    10460980
  • 财政年份:
    2004
  • 资助金额:
    $ 53.96万
  • 项目类别:

相似海外基金

Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
  • 批准号:
    MR/S03398X/2
  • 财政年份:
    2024
  • 资助金额:
    $ 53.96万
  • 项目类别:
    Fellowship
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
  • 批准号:
    2338423
  • 财政年份:
    2024
  • 资助金额:
    $ 53.96万
  • 项目类别:
    Continuing Grant
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
  • 批准号:
    EP/Y001486/1
  • 财政年份:
    2024
  • 资助金额:
    $ 53.96万
  • 项目类别:
    Research Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
  • 批准号:
    MR/X03657X/1
  • 财政年份:
    2024
  • 资助金额:
    $ 53.96万
  • 项目类别:
    Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
  • 批准号:
    2348066
  • 财政年份:
    2024
  • 资助金额:
    $ 53.96万
  • 项目类别:
    Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
  • 批准号:
    AH/Z505481/1
  • 财政年份:
    2024
  • 资助金额:
    $ 53.96万
  • 项目类别:
    Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
  • 批准号:
    10107647
  • 财政年份:
    2024
  • 资助金额:
    $ 53.96万
  • 项目类别:
    EU-Funded
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
  • 批准号:
    2341402
  • 财政年份:
    2024
  • 资助金额:
    $ 53.96万
  • 项目类别:
    Standard Grant
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
  • 批准号:
    10106221
  • 财政年份:
    2024
  • 资助金额:
    $ 53.96万
  • 项目类别:
    EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
  • 批准号:
    AH/Z505341/1
  • 财政年份:
    2024
  • 资助金额:
    $ 53.96万
  • 项目类别:
    Research Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了