An integrative multisite study of the influence of socioeconomic disparities on hippocampal subfields developmental trajectories

社会经济差异对海马亚区发育轨迹影响的综合多中心研究

• 批准号: 10674474
• 负责人: Kelsey Leigh Canada
• 金额: $ 7.47万
• 依托单位: WAYNE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10674474
• 关键词: 4 year old; Acceleration; Address; Adolescence; Adult; Age; Autopsy; Brain; Caring; Childhood; Communities; Data; Data Analyses; Development; Distress; Early identification; Education; Environment; Environmental Risk Factor; Future; Geography; Goals; Hippocampus; Household; Human; Income; Individual; Intervention; Learning; Link; Literature; Measures; Medical; Memory; Memory impairment; Mental Depression; Methodology; Methods; Modeling; Neighborhoods; Neurodevelopmental Disorder; Occupations; Population; Procedures; Protocols documentation; Proxy; Public Health; Research; Resources; Risk; Sample Size; Sampling; Sampling Studies; Scanning; Schizophrenia; Site; Socioeconomic Status; Stress; Structure; Testing; United States; Variant; Work; behavioral outcome; candidate marker; cognitive ability; cognitive development; community intervention; data integration; dentate gyrus; early childhood; early life adversity; high resolution imaging; indexing; longitudinal dataset; low socioeconomic status; middle childhood; neuroimaging; novel; social capital; socioeconomic disparity; socioeconomics; ultra high resolution; young adult

PROJECT SUMMARY/ABSTRACT The hippocampus is composed of cytoarchitecturally-distinct subfields that support specific memory and learning functions. Evidence suggests distinct developmental trajectories in hippocampal subfields throughout childhood and adolescence, periods in which environmental factors exact strong influence on brain development. However, evidence is largely from cross-sectional samples, is based on inconsistent practices for delineations of subfields, and is limited by the power and diversity within single studies. Thus, developmental trajectories of hippocampal subfields remain unclear, prohibiting the systematic study of the influence of environmental factors on hippocampal development. Variations in total hippocampal volume across development have been linked to socioeconomic status, a proxy for access to material resources, medical care, and quality education in one’s environment. Low household socioeconomic status in childhood is associated with worse cognitive abilities later in adulthood, and low neighborhood socioeconomic status (an additional index of social capital and connectedness) further predicts poor behavioral outcomes beyond the household, especially in adolescence. The proposed study examines differential vulnerability of hippocampal subfield structures to variations in household and neighborhood socioeconomic across development. Understanding of normative developmental changes in subfield structure and vulnerability to low socioeconomic environments can have significant implications for individual and community interventions. However, testing these questions requires a large sample size, adequate coverage of age, specialized ultra-high-resolution scans, and sufficient representation of the diverse United States population. The proposed study will achieve this using integrative data analysis, an advanced latent modeling approach that directly addresses differences in methodologies while allowing new hypotheses to be tested in existing data. Hypotheses will be tested using a novel integrated longitudinal dataset of 678 typically developing subjects covering the span of 4- to- 25-years from four geographically- and demographically-diverse sites across the United States by pursuing these specific aims: Aim 1) Characterize typical developmental trajectories of hippocampal subfields in a diverse multi-site study pediatric sample; and Aim 2) Elucidate the link between variations in socioeconomic status and the development of hippocampal subfields. The hippocampus is implicated in neurodevelopmental disorders such as depression, schizophrenia, and low SES also confers risk for neurodevelopmental disorders. Thus, obtaining accurate characterization of hippocampal subfield development trajectories and identifying the effects of household and neighborhood SES in a large sample will pave the way for early identification of neurodevelopmental disorders and targeted intervention for specific factors associated with socioeconomic disparity. Further, the successful application of integrative data analysis to neuroimaging data from multiple studies will demonstrate a means to leverage existing data to answer critical questions otherwise not feasible in individual studies.

项目摘要/摘要 海马体由支持特定记忆和学习的细胞结构不同的亚区组成 功能。有证据表明，在整个童年时期，海马区有不同的发育轨迹 青春期是环境因素对大脑发育产生强烈影响的时期。然而， 证据主要来自横断面样本，基于不一致的划分子域的做法， 而且受到单一研究的力量和多样性的限制。因此，海马区的发育轨迹 子领域仍然不清楚，阻碍了对环境因素影响的系统研究 海马体发育。海马体总体积在发育过程中的变化与 社会经济地位，一个人获得物质资源、医疗保健和优质教育的代名词 环境。童年时期家庭社会经济地位低与以后认知能力较差有关 成年期和较低的社区社会经济地位(社会资本和 连接性)进一步预示着家庭以外的不良行为结果，尤其是在青春期。 这项拟议的研究考察了海马子区结构对不同类型的 家庭和邻里社会经济的全面发展。对规范发展的理解 子领域结构的变化和对低社会经济环境的脆弱性可能会产生重大影响 对个人和社区干预的影响。然而，测试这些问题需要大量的 样本大小，足够的年龄覆盖范围，专业的超高分辨率扫描，以及足够的代表性 多元化的美国人口。拟议的研究将使用综合数据分析和 高级潜在建模方法，直接解决方法上的差异，同时允许新的 假设需要在现有数据中进行检验。假设将使用一种新的集成纵向数据集进行验证 在678个典型的开发对象中，覆盖了四个地理位置跨度为4到25年的对象-以及 通过追求这些特定目标，在美国各地实现人口结构多样化的网站：目标1)表征 不同的多点研究儿童样本中海马区的典型发育轨迹；以及 目的2)阐明社会经济地位的变化与海马体发育之间的联系 子字段。海马体与神经发育障碍有关，如抑郁症、精神分裂症、 而低SES也会增加神经发育障碍的风险。因此，获得准确的表征 家庭和邻里SES对海马子区发育轨迹的影响 大样本将为神经发育障碍的早期识别和针对性研究铺平道路 对与社会经济差距相关的特定因素进行干预。此外，成功地应用了 对多项研究的神经成像数据进行综合数据分析将展示一种利用 现有的数据来回答关键问题，否则在个别研究中是不可行的。